Author: Rebecca P. FreemanPublisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Approaches to the Total Synthesis of Laurenyne
Author: Rebecca P. FreemanMore Dead Ends and Detours
Author: Miguel A. SierraPublisher: John Wiley & Sons
ISBN: 352765464X
Category : Science
Languages : en
Pages : 297
Book Description
Success comes in many forms and in synthesis it can be a failure that results in their ultimate successful solutions. This long-awaited sequel to "Dead Ends and Detours" retains the proven concept while featuring over 20 new case studies of failed strategies and their (successful) solutions in natural product total synthesis. Additionally, computational models are used to discuss the problem in much more detail and to provide readers with additional information not found in the primary literature. The topics range from classic synthetic reactions (e.g. Diels Alder reaction), metal-mediated coupling reactions, metathesis, and asymmetric catalysis to the importance of protecting and activating groups. This book will benefit not only graduate students in organic chemistry but also advanced researchers as they gain knowledge derived from the step-by-step analysis of mistakes made in the past and, thus be able to improve their own chemical reaction planning. With its coverage of the most commonly applied reaction types, the book perfectly complements its predecessor, which focuses on general aspects, such as reactivity and selectivity.
Approaches to the Total Synthesis of the Lamellarins and Related Natural Products
Author: Yanan ZhangPublisher:
ISBN: 9780542192142
Category : Alkaloids
Languages : en
Pages : 364
Book Description
Approaches to the Total Synthesis of Wilfordine
Author: Darren Lee WhitehousePublisher:
ISBN:
Category :
Languages : en
Pages : 166
Book Description
Approaches to the Total Synthesis of the Complanadines
Author: Mario Uosis-MartinPublisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
In this thesis is presented work carried out during the course of the last 42 months. It concerns approaches towards total syntheses of the complanadine alkaloids. The main focus is the development of a model system to establish the viability of the key step in our proposed route to the complanadines. The thesis is divided into five chapters. Chapter 1 is an introduction to the complanadines, their biological activity and accomplished total syntheses to date. A brief introduction to the Diels-Alder reaction and selected examples of its application in the total syntheses of natural products are given. The Kondrat'eva oxazole-olefin hetero-Diels-Alder reaction as a method of pyridine formation is described and its application in the total synthesis of natural products is reviewed. Chapter 2 is the first part of the results and discussion section. It details our retrosynthetic analysis of complanadine A, outlines the corresponding proposed forward synthesis and presents a model system designed and synthesised to test the applicability of the Kondrat'eva oxazole-olefin hetero-Diels-Alder reaction in the context of our proposed total synthesis. Chapter 3 discusses work carried out in approaches to the total synthesis of complanadines and their monomeric subunit, lycodine, by means of the methodology developed in the previous chapter. Chapter 4 is the experimental section, which gives descriptions of the synthetic procedures employed and spectroscopic data for all compounds synthesised, both novel and previously reported, as discussed in Chapter 2 and Chapter 3. Supplementary information such as X-Ray data for synthesised compounds and selected NMR spectra are enclosed in the appendices.
The Total Synthesis of Natural Products, Volume 6
Author: John ApSimonPublisher: John Wiley & Sons
ISBN: 0470129573
Category : Science
Languages : en
Pages : 306
Book Description
The sixth volume of The Total Synthesis of Natural Products continues editor John ApSimon's exploration of one of the most promising areas for the future development of organic chemistry: synthesis. ApSimon has compiled the first definitive reference source of successful synthetic approaches to a wide variety of natural products. This new volume considers the total synthesis of triterpenes, carbohydrates, aromatic steroids, pyrrole pigments and genes first reported during the period from 1972 through 1982 in this series. The Total Synthesis of Natural Products, Volume Six forms an integral part of the invaluable working reference begun in Volumes One through Five, to which chemists may turn for the available data on the total synthesis of complex molecules. Lessons learned from the synthetic challenges presented here by various natural products will serve as a sound base for this continually evolving field.
Approaches to Asymmetric Total Synthesis
Author: Mark James FordAn Approach to the Total Synthesis of (+)-lythranidine and a Study of the Addition of Nitrones to Indoles
Author: Hsiang-Ching KungApproach to the Total Synthesis of Massileunicellins
Author: Zonghong MouPublisher:
ISBN:
Category : Diterpenes
Languages : en
Pages : 80
Book Description
Author: Graeme James Dykes