Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Applied Adaptive Statistical Methods PDF full book. Access full book title Applied Adaptive Statistical Methods by Thomas W. O'Gorman. Download full books in PDF and EPUB format.
Author: Thomas W. O'Gorman Publisher: SIAM ISBN: 0898715539 Category : Mathematics Languages : en Pages : 180
Book Description
Introduces many of the practical adaptive statistical methods and provides a comprehensive approach to tests of significance and confidence intervals.
Author: Thomas W. O'Gorman Publisher: SIAM ISBN: 0898715539 Category : Mathematics Languages : en Pages : 180
Book Description
Introduces many of the practical adaptive statistical methods and provides a comprehensive approach to tests of significance and confidence intervals.
Author: Thomas W. O'Gorman Publisher: SIAM ISBN: 9780898718430 Category : Mathematics Languages : en Pages : 187
Book Description
Adaptive statistical tests, developed over the last 30 years, are often more powerful than traditional tests of significance, but have not been widely used. To date, discussions of adaptive statistical methods have been scattered across the literature and generally do not include the computer programs necessary to make these adaptive methods a practical alternative to traditional statistical methods. Until recently, there has also not been a general approach to tests of significance and confidence intervals that could easily be applied in practice. Modern adaptive methods are more general than earlier methods and sufficient software has been developed to make adaptive tests easy to use for many real-world problems. Applied Adaptive Statistical Methods: Tests of Significance and Confidence Intervals introduces many of the practical adaptive statistical methods developed over the last 10 years and provides a comprehensive approach to tests of significance and confidence intervals. It shows how to make confidence intervals shorter and how to make tests of significance more powerful by using the data itself to select the most appropriate procedure.
Author: Anthony C Atkinson Publisher: CRC Press ISBN: 1584886935 Category : Mathematics Languages : en Pages : 341
Book Description
Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.
Author: Scott M. Berry Publisher: CRC Press ISBN: 1439825513 Category : Mathematics Languages : en Pages : 316
Book Description
Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer's disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adapti
Author: Michael R. Kosorok Publisher: SIAM ISBN: 1611974178 Category : Medical Languages : en Pages : 354
Book Description
Personalized medicine is a medical paradigm that emphasizes systematic use of individual patient information to optimize that patient's health care, particularly in managing chronic conditions and treating cancer. In the statistical literature, sequential decision making is known as an adaptive treatment strategy (ATS) or a dynamic treatment regime (DTR). The field of DTRs emerges at the interface of statistics, machine learning, and biomedical science to provide a data-driven framework for precision medicine.? The authors provide a learning-by-seeing approach to the development of ATSs, aimed at a broad audience of health researchers. All estimation procedures used are described in sufficient heuristic and technical detail so that less quantitative readers can understand the broad principles underlying the approaches. At the same time, more quantitative readers can implement these practices. This book provides the most up-to-date summary of the current state of the statistical research in personalized medicine; contains chapters by leaders in the area from both the statistics and computer sciences fields; and also contains a range of practical advice, introductory and expository materials, and case studies.?
Author: Thomas W. O'Gorman Publisher: John Wiley & Sons ISBN: 0470922257 Category : Mathematics Languages : en Pages : 365
Book Description
Provides the tools needed to successfully perform adaptive tests across a broad range of datasets Adaptive Tests of Significance Using Permutations of Residuals with R and SAS illustrates the power of adaptive tests and showcases their ability to adjust the testing method to suit a particular set of data. The book utilizes state-of-the-art software to demonstrate the practicality and benefits for data analysis in various fields of study. Beginning with an introduction, the book moves on to explore the underlying concepts of adaptive tests, including: Smoothing methods and normalizing transformations Permutation tests with linear methods Applications of adaptive tests Multicenter and cross-over trials Analysis of repeated measures data Adaptive confidence intervals and estimates Throughout the book, numerous figures illustrate the key differences among traditional tests, nonparametric tests, and adaptive tests. R and SAS software packages are used to perform the discussed techniques, and the accompanying datasets are available on the book's related website. In addition, exercises at the end of most chapters enable readers to analyze the presented datasets by putting new concepts into practice. Adaptive Tests of Significance Using Permutations of Residuals with R and SAS is an insightful reference for professionals and researchers working with statistical methods across a variety of fields including the biosciences, pharmacology, and business. The book also serves as a valuable supplement for courses on regression analysis and adaptive analysis at the upper-undergraduate and graduate levels.
Author: Annpey Pong Publisher: CRC Press ISBN: 1439810176 Category : Mathematics Languages : en Pages : 475
Book Description
In response to the US FDA's Critical Path Initiative, innovative adaptive designs are being used more and more in clinical trials due to their flexibility and efficiency, especially during early phase development. Handbook of Adaptive Designs in Pharmaceutical and Clinical Development provides a comprehensive and unified presentation of the princip
Author: Bernhard Schipp Publisher: Springer Science & Business Media ISBN: 3790821217 Category : Mathematics Languages : en Pages : 438
Book Description
This Festschrift is dedicated to Götz Trenkler on the occasion of his 65th birthday. As can be seen from the long list of contributions, Götz has had and still has an enormous range of interests, and colleagues to share these interests with. He is a leading expert in linear models with a particular focus on matrix algebra in its relation to statistics. He has published in almost all major statistics and matrix theory journals. His research activities also include other areas (like nonparametrics, statistics and sports, combination of forecasts and magic squares, just to mention afew). Götz Trenkler was born in Dresden in 1943. After his school years in East G- many and West-Berlin, he obtained a Diploma in Mathematics from Free University of Berlin (1970), where he also discovered his interest in Mathematical Statistics. In 1973, he completed his Ph.D. with a thesis titled: On a distance-generating fu- tion of probability measures. He then moved on to the University of Hannover to become Lecturer and to write a habilitation-thesis (submitted 1979) on alternatives to the Ordinary Least Squares estimator in the Linear Regression Model, a topic that would become his predominant ?eld of research in the years to come.
Author: Karl E. Peace Publisher: Springer ISBN: 9811078297 Category : Medical Languages : en Pages : 414
Book Description
This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments – particularly biopharmaceutical clinical trials. The papers were selected from invited presentations at the Biopharmaceutical Applied Statistics Symposium (BASS), which was founded by the first Editor in 1994 and has since become the premier international conference in biopharmaceutical statistics. The primary aims of the BASS are: 1) to raise funding to support graduate students in biostatistics programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights into solving the problems they encounter.The BASS book series is initially divided into three volumes addressing: 1) Design of Clinical Trials; 2) Biostatistical Analysis of Clinical Trials; and 3) Pharmaceutical Applications. This book is the first of the 3-volume book series. The topics covered include: A Statistical Approach to Clinical Trial Simulations, Comparison of Statistical Analysis Methods Using Modeling and Simulation for Optimal Protocol Design, Adaptive Trial Design in Clinical Research, Best Practices and Recommendations for Trial Simulations in the Context of Designing Adaptive Clinical Trials, Designing and Analyzing Recurrent Event Data Trials, Bayesian Methodologies for Response-Adaptive Allocation, Addressing High Placebo Response in Neuroscience Clinical Trials, Phase I Cancer Clinical Trial Design: Single and Combination Agents, Sample Size and Power for the Mixed Linear Model, Crossover Designs in Clinical Trials, Data Monitoring: Structure for Clinical Trials and Sequential Monitoring Procedures, Design and Data Analysis for Multiregional Clinical Trials – Theory and Practice, Adaptive Group-Sequential Multi-regional Outcome Studies in Vaccines, Development and Validation of Patient-reported Outcomes, Interim Analysis of Survival Trials: Group Sequential Analyses, and Conditional Power – A Non-proportional Hazards Perspective.
Author: Michael R. Kosorok Publisher: SIAM ISBN: 1611974186 Category : Medical Languages : en Pages : 348
Book Description
Personalized medicine is a medical paradigm that emphasizes systematic use of individual patient information to optimize that patient's health care, particularly in managing chronic conditions and treating cancer. In the statistical literature, sequential decision making is known as an adaptive treatment strategy (ATS) or a dynamic treatment regime (DTR). The field of DTRs emerges at the interface of statistics, machine learning, and biomedical science to provide a data-driven framework for precision medicine. The authors provide a learning-by-seeing approach to the development of ATSs, aimed at a broad audience of health researchers. All estimation procedures used are described in sufficient heuristic and technical detail so that less quantitative readers can understand the broad principles underlying the approaches. At the same time, more quantitative readers can implement these practices. This book provides the most up-to-date summary of the current state of the statistical research in personalized medicine; contains chapters by leaders in the area from both the statistics and computer sciences fields; and also contains a range of practical advice, introductory and expository materials, and case studies.
Author: Thomas W. O'Gorman
Author: Thomas W. O'Gorman
Author: Thomas W. O'Gorman
Author: Anthony C Atkinson
Author: Scott M. Berry
Author: Michael R. Kosorok
Author: Thomas W. O'Gorman
Author: Annpey Pong
Author: Bernhard Schipp
Author: Karl E. Peace
Author: Michael R. Kosorok