Author: Carl Warren Publisher: Lundberg Press ISBN: 1446508684 Category : Technology & Engineering Languages : en Pages : 188
Book Description
Many of the earliest books, particularly those dating back to the 1900s and before, are now extremely scarce and increasingly expensive. We are republishing many of these classic works in affordable, high quality, modern editions, using the original text and artwork.
Author: Ian Gordon Publisher: CABI ISBN: 9780851990491 Category : Technology & Engineering Languages : en Pages : 356
Book Description
In the past half century great progress has been made in the reproductive management of farm animals, both mammals and birds. This book aims to review developments and indicate which reproductive technologies can be used commercially or in research. It begins by discussing artificial insemination and how this has recently been refined in semen sexing technology. Embryo transfer, in vitro embryo production technology and the control of oestrus and ovulation are then reviewed. Subsequent chapters consider the control of postpartum ovarian activity, seasonal breeding, multiple births and litter size, pregnancy testing, parturition, and the onset of puberty. The author then describes more recent developments in cloning and the production of transgenic animals, before a final chapter on suppressing reproductive activity.
Author: Tristram D. Wyatt Publisher: Oxford University Press ISBN: 019102094X Category : Science Languages : en Pages : 169
Book Description
How animals behave is crucial to their survival and reproduction. The application of new molecular tools such as DNA fingerprinting and genomics is causing a revolution in the study of animal behaviour, while developments in computing and image analysis allow us to investigate behaviour in ways never previously possible. By combining these with the traditional methods of observation and experiments, we are now learning more about animal behaviour than ever before. In this Very Short Introduction Tristram D. Wyatt discusses how animal behaviour has evolved, how behaviours develop in each individual (considering the interplay of genes, epigenetics, and experience), how we can understand animal societies, and how we can explain collective behaviour such as swirling flocks of starlings. Using lab and field studies from across the whole animal kingdom, he looks at mammals, butterflies, honeybees, fish, and birds, analysing what drives behaviour, and exploring instinct, learning, and culture. Looking more widely at behavioural ecology, he also considers some aspects of human behaviour. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Author: V L Bianki Publisher: CRC Press ISBN: 0203304640 Category : Medical Languages : en Pages : 224
Book Description
Until recently, little account has been taken of sex differences in many research studies in psychiatry, medicine and physiology. Subjects of these research studies were mainly men, with most researchers using twice as many males as females in their studies. The need to take a sexually differentiated approach has led to the work described in this book, concerning detailed investigations into the correlations between functional asymmetry of the brain and sex. Sex Differences in Lateralization in the Animal Brain is the first monograph summarizing the sexual specificity of functional lateralization of the brain in animals and humans. It is based on original experimental data from animals and will be of interest to biologists, psychologists and neurobiologists.
Author: Franz J. Hock Publisher: Springer Nature ISBN: 3031355296 Category : Medical Languages : en Pages : 2751
Book Description
Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily conducted to confirm whether the selected compound possesses a suitable half-life for sufficient exposure and efficacy and, whether it has the desired properties specificity to the intended route of administration. Safety aspects relied predominantly on the conduct of single and repeat toxicologydose studies, which inform changes in organ structure rather than organ function. Both toxicological and pharmacokinetic studies are adapted to the progress of studies in clinical pharmacology and clinical trials. The new edition of this well and broadly accepted reference work contains several innovative and distinguished chapters. This "sequential" strategy has been abandoned with this new version of the book for several reasons: - Of the possible multitude of negative effects that novel drugs may impart on organ function, e.g. ventricular tachy-arrhythmia, many are detected too late in non-clinical studies to inform clinicians. On the other hand, negative findings in chronic toxicity studies in animals may turn out to be irrelevant for human beings. - New scientific approaches, e.g. high-throughput screening, human pluripotent stem cells, transgenic animals, knock-out animals, in silico models, pharmaco-genomics and pharmaco-proteomics, as well as Artificial Intelligence (AI) methods offered new possibilities. - There are several examples, that show that the "druggability" of compounds was considerably underestimated when the probability of success of a new project was assessed. The success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. Research and development scientists, involving the following changes, therefore adopted a change of strategy: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization). - The term "Safety Pharmacology" was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group and the Safety Pharmacology Society (SPS) was launched. The discipline provided for evaluation, development and validation of a multitude of safety tests outlined in the 'Core Battery of Studies'. - Characterizing the exposure profile of a drug by conducting pharmacokinetic studies that evaluates the absorption, distribution, metabolism and excretion should to be investigated at an early stage of development as results contribute to the selection of a compound for further development. Advancements in Toxicology were achieved by the introduction of new methods, e.g., in silico methods, genetic toxicology, computational toxicology and AI. The book is a landmark in the continuously changing world of drug research and developments. As such, it is essential reading for many groups: not only for all students of pharmacology and toxicology but also for industry scientists and physicians, especially those involved in clinical trials of drugs, and for pharmacists who must know the safety requirements of drugs. The book is essential for scientists and managers in the pharmaceutical industry who are involved in drug discovery, drug development and decision making in the development process. In particular, the book will be of use to government institutions and committees working on official guidelines for drug evaluation worldwide.
Author: OECD Publisher: OECD Publishing ISBN: 9264221476 Category : Languages : en Pages : 156
Book Description
This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453.
Author: Carl Warren
Author: Carl Warren
Author: Ian Gordon
Author: Tristram D. Wyatt
Author: Arthur Sperry Pearse
Author: V L Bianki
Author: Franz J. Hock
Author: 
Author: OECD
Author: