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Author: Thomas W. Traut Publisher: Springer Science & Business Media ISBN: 0387728910 Category : Science Languages : en Pages : 255
Book Description
This book covers the most recent developments in the analysis of allosteric enzymes and provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. The book presents a complete description of all the mechanisms used for changing enzyme activity. It is extensively illustrated to clarify kinetic and regulatory properties. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.
Author: Thomas W. Traut Publisher: Springer Science & Business Media ISBN: 0387728910 Category : Science Languages : en Pages : 255
Book Description
This book covers the most recent developments in the analysis of allosteric enzymes and provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. The book presents a complete description of all the mechanisms used for changing enzyme activity. It is extensively illustrated to clarify kinetic and regulatory properties. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.
Author: Guy Herve Publisher: CRC Press ISBN: 1000098826 Category : Science Languages : en Pages : 269
Book Description
This book compiles detailed information concerning a dozen of the best known allosteric enzymes, and so allows the comparison of their regulatory mechanisms and the confrontation of these mechanisms with the theoretical models. Stimulating and unexpected ideas emerge from these comparisons and emphasize the importance of developing various methods of investigation such as crystallography, X-ray solution scattering, and the study of fast movements in proteins and site-directed mutagenesis. This book is addressed to students and researchers interested in structure-function relationship in proteins, enzymology and metabolic regulation. It is also a basis for teaching.
Book Description
A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: * The structure, regulation and expression of the AP genes * The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes * The phenotypic abnormalities of the different AP knockout mice * Our current understanding of the in vivo role of the AP isozymes. The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzymes in clinical medicine and in biotechnology.
Author: Hans Bisswanger Publisher: John Wiley & Sons ISBN: 3527806474 Category : Science Languages : en Pages : 340
Book Description
Now in full color for a more intuitive learning experience, this new edition of the long-selling reference also features a number of new developments in methodology and the application of enzyme kinetics. Starting with a description of ligand binding equilibria, the experienced author goes on to discuss simple and complex enzyme reactions in kinetic terms. Special cases such as membrane-bound and immobilized enzymes are considered, as is the influence of external conditions, such as temperature and pH value. The final part of the book then covers a range of widely used measurement methods and compares their performance and scope of application. With its unique mix of theory and practical advice, this is an invaluable aid for teaching as well as for experimental work.
Author: Antonio Baici Publisher: Springer ISBN: 3709114020 Category : Science Languages : en Pages : 503
Book Description
The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.
Author: William K. Purves Publisher: Macmillan ISBN: 9780716738732 Category : Science Languages : en Pages : 1376
Book Description
Authoritative, thorough, and engaging, Life: The Science of Biology achieves an optimal balance of scholarship and teachability, never losing sight of either the science or the student. The first introductory text to present biological concepts through the research that revealed them, Life covers the full range of topics with an integrated experimental focus that flows naturally from the narrative. This approach helps to bring the drama of classic and cutting-edge research to the classroom - but always in the context of reinforcing core ideas and the innovative scientific thinking behind them. Students will experience biology not just as a litany of facts or a highlight reel of experiments, but as a rich, coherent discipline.
Author: Anatoly Bezkorovainy Publisher: CRC Press ISBN: 9781420001358 Category : Medical Languages : en Pages : 646
Book Description
This work offers succinct, medically-oriented coverage of biochemistry, examining biologically important materials and presenting the properties of nucleic acids as well as nucleic acid metabolism. Each metabolic process is integrated in a review of overall energy metabolism, diabetes and starvation. A solutions manual is available to instructors only.
Author: Thomas W. Traut
Author: Thomas W. Traut
Author: Guy Herve
Author: José Luis Millan
Author: Hans Bisswanger
Author: Albert L. Lehninger
Author: 
Author: Antonio Baici
Author: Debajyoti Das
Author: William K. Purves
Author: Anatoly Bezkorovainy