Advances in Skeletal Reconstruction Using Bone Morphogenetic Proteins PDF Download

Author: T. Sam Lindholm
Publisher: World Scientific
ISBN: 981024729X
Category : Science
Languages : en
Pages : 479

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Book Description
The bone morphogenetic protein (BMP) is a special growth factor for the induction of new bone formation. Today, the extract of the BMP originating from bone tissue as well as genetically modified BMPs, particularly BMP-2 and -7, can be used. Though the BMP as an implant is as yet an unregistered drug or medical tool in Europe and the US, specialists are confident that it will obtain final government approval based on the results of clinical tests conducted on more than 3000 patients. This important book focuses mainly on the clinical BMP treatment of patients -- namely in orthopaedic cases (fractures, bone transplants, non-unions and pseudoarthroses), maxillofacial surgery (sinus lift before dental implantation), dental surgery (filling out of cavities) and spinal surgery (using a BMP implant instead of the patient's own bone).

Author: Slobodan Vukicevic
Publisher: Springer
ISBN: 3034878575
Category : Science
Languages : en
Pages : 320

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Book Description
Since the discovery of the bone morphogenetic proteins (BMPs) more than 15 years ago, there has been an unpredicted explosion of both basic scientific discoveries and clinical reports on their use from institutions all over the world. The potent effica cy of BMPs in almost all crucial developmental events as well as during regenera tion of various organs such as bone, kidney, brain, liver, heart etc. , has positioned BMPs at the center of scientific interest. Many of these aspects are covered in this new PIR volume. Their role in development, biology, signal transduction, kidney regeneration, eNS functions, craniofacial skeleton reconstruction, joint and carti lage repair, long bone non-unions and acute fractures, and spinal fusion is reviewed by experts in the field. For the first time, the role of BMPs in carcinogenesis has been reviewed to provide a rationale for applying their biology in patients with bone tumors. The optimism resulting from safe and successful treatment with BMPs for various skeletal malformations of more than 10,000 patients worldwide has opened new avenues for exploring other indications for their use. The next big challenge for bringing BMPs to the benefit ofmankind is in regenerating articular cartilage defects and rescuing patients with acute and chronic renal failure. The volume editors thank all authors for the rapid preparation of their chapters in order that the book remains up-to-date for readers with specific interest in the field of regenerative medicine. The important contribution of Mrs. Morana and Mr.

Author: Slobodan Vukicevic
Publisher: Springer
ISBN: 3034881215
Category : Science
Languages : en
Pages : 335

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Book Description
From the basic science to potential and approved clinical applications the most recent data in the rapidly growing field of bone morphogenetic proteins (BMPs) are summarized in this topical volume. Distinguished scientists present reviews on a range of scientific topics, including biochemistry, biology, molecular biology and preclinical animal studies on spinal fusion, cartilage repair, craniofacial and dental reconstruction using BMPs, as well as approved clinical applications in human bone non-unions. This book provides a resource not only for experts in the field, but also for undergraduate students, newcomers and clinicians worldwide, given that the use of BMPs in orthopedic reconstruction has been already approved in Europe, Australia, Canada and the USA.

Author: Slobodan Vukicevic
Publisher: Springer Science & Business Media
ISBN: 3764385529
Category : Science
Languages : en
Pages : 349

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Book Description
Completing the PIR series, this volume summarizes the major advances made in the local and systemic use of bone morphogenetic proteins (BMPs). Chapters are dedicated to the regulation of BMP-signaling pathways; biological actions of BMPs in bone, cartilage, and teeth; clinical applications; and the potential systemic use of BMPs for tissues beyond bone. The authors are all recognized experts in the field of tissue engineering and regeneration.

Author:
Publisher: ScholarlyEditions
ISBN: 1464932417
Category : Medical
Languages : en
Pages : 94

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Book Description
Bone Morphogenetic Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Bone Morphogenetic Proteins in a concise format. The editors have built Bone Morphogenetic Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bone Morphogenetic Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bone Morphogenetic Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author: Glyn O. Phillips
Publisher: World Scientific
ISBN: 9789812795298
Category : Medical
Languages : en
Pages : 172

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Book Description
What are bone morphogenetic proteins (BMPs) and how can they be used in orthopaedic practice? Ever since Urist proposed in 1976 that protein factors from cortical bone appeared to modulate bone healing in animals, there has been a search for these mysterious osteoinductive components. Now that their structure has been elucidated, they have been purified and cloned, and are now available for the improvement of bone healing. The best source of BMPs is demineralised bone. This bone allograft is used to achieve greater osteoinductive capacity. But are the actions of procurement, processing, demineralisation and sterilisation harmful to the BMPs? Unless the BMPs can be assayed, neither their clinical nor their scientific effectiveness can be appraised. All these aspects are logically and scientifically described in this volume. In addition, there is a review of the biochemistry of one of the two main components of bone, namely collagen. This subject is itself a confusing but rapidly growing field. This comprehensive review describes the procedures for building up bone in vivo and in vitro . Bone Morphogenetic Protein and Collagen answers most of the questions of orthopaedic surgeons and tissue bankers on how BMPs can be produced and used to their maximum effectiveness. Contents: From Bone Allografts to Synthetic Bone Grafts: Bone Morphogenetic Proteins and Osteoinduction; The Osteoinductive Properties of Demineralised Bone Matrix Grafts; Processing Factors Contributing to Production of Maximally Osteoinductive Demineralised Ground Bone; Clinical Effectiveness of Demineralised Bone Matrix Assayed in Human Cell Culture; The Influence of Sterilisation on the Osteoinductive Properties of Bone in Rat Bone Marrow Cell Culture; Collagen Biochemistry: An Overview. Readership: Orthopaedic surgeons who use tissue allografts in bone and related reconstructions.

Author: Veikko V. Viljanen
Publisher:
ISBN: 9789514442124
Category :
Languages : en
Pages : 133

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Book Description

Author: Lindholm
Publisher:
ISBN: 9783540635291
Category :
Languages : en
Pages : 251

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Book Description
This book presents new information on the use of demineralized bone matrix and osteoinductive proteins (bone morphogenetic proteins) as bioactive grafts in reconstructive surgery (orthopedic and maxillofacial surgery), and details the measurement of osteoinductivity in animal experiments and in clinical use. The biochemical mechanisms and clinical implications for skeletal reconstruction and bioimplantation are presented in three sections: (1) Documentation of Osteoinductivity, (2) Bioactive Delivery Systems, and (3) Genetics and Osteoinduction. The use of osteoinductive implants in bone transplantation should become standard practice, and Skeletal Reconstruction and Bioimplantation will be considered among the pioneering works in the field.

Author: Jeffrey O. Hollinger
Publisher: CRC Press
ISBN: 1135501912
Category : Medical
Languages : en
Pages : 500

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Book Description
Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Author: Dominique G. Poitout
Publisher: Springer Science & Business Media
ISBN: 9781852334819
Category : Medical
Languages : en
Pages : 694

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Book Description
Current clinical orthopedic practice requires practitioners to have extensive knowledge of a wide range of disciplines from molecular biology to bioengineering and from the application of new methods to the evaluation of outcome. The biomechanics of and biomaterials used in orthopedics have become increasingly important as the possibilities have increased to treat patients with foreign material introduced both as optimized osteosynthesis after trauma and as arthroplasties for joint diseases, sequelae of trauma or for tumor treatment. Furthermore, biomaterial substitutes are constantly being developed to replace missing tissue. Biomechanics and Biomaterials in Orthopedics provides an important update within this highly important field. Professor Dominique Poitout has collected a series of high-quality chapters by globally renowned researchers and clinicians. Under the auspices of the International Society of Orthopaedic Surgery and Traumatology (SICOT) and International Society of Orthopaedic and Traumatology Research (SIROT), this book now provides permanent and specific access to the considerable international knowledge in the field of locomotor system trauma and disease treatment using the novel bioengineering solutions. This book covers both basic concepts concerning biomaterials and biomechanics as well as their clinical application and the experience from everyday practical use. This book will be of great value to specialists in orthopedics and traumatology, while also provide an important basis for graduate and postgraduate learning.