Advances in Non-Alcoholic Fatty Liver Disease Therapeutics: Pathogenic Mechanisms and Targets PDF Download

Author: Ana Blas-García
Publisher: Frontiers Media SA
ISBN: 2832508588
Category : Science
Languages : en
Pages : 190

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Author: Yong Gao
Publisher: Frontiers Media SA
ISBN: 283254374X
Category : Science
Languages : en
Pages : 468

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The global incidence of gastrointestinal and hepatic diseases has been gradually increasing in recent years, which seriously threatens human health and increases the economic burden. More importantly, gastrointestinal and hepatic malignancies have the highest incidence and mortality rates among all tumors, such as liver cancer, stomach cancer, colon cancer, and pancreatic cancer. There are also non-neoplastic diseases such as viral hepatitis, cirrhosis, nonalcoholic steatohepatitis, chronic atrophic gastritis, ulcerative colitis, and reflux esophageal disease that also affect patients' quality of life. Although progress has been made in the pathogenesis of gastrointestinal and hepatic diseases, and corresponding therapeutic drugs have been also developed, the specific mechanisms of the diseases are still not revealed and there is a lack of specific drugs. In view of this, this topic aims to explore new molecular mechanisms of pathogenesis and potential therapeutic agents and pharmacological effects of gastrointestinal and hepatic diseases.

Author: Shao Li
Publisher: Springer Nature
ISBN: 9811607532
Category : Medical
Languages : en
Pages : 480

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This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.

Author: Naga Chalasani
Publisher: Springer
ISBN: 3319205382
Category : Medical
Languages : en
Pages : 378

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This volume is the first text to concisely yet comprehensively cover developments for both alcoholic and nonalcoholic fatty liver disease in an organized fashion. Aspects of these two diseases covered in the book include global epidemiology and risk factors, pathogenesis, animal models, hepatic and extra-hepatic malignancies, treatment models, and current and emerging therapies. Written by experts in the field, Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside is a valuable resource for gastroenterologists, pathologists, and hepatologists who treat patients with alcoholic and nonalcoholic fatty liver disease.

Author: Lawrence H. Lash
Publisher: Elsevier
ISBN: 1483218619
Category : Science
Languages : en
Pages : 527

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Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Author: Aparajita Dey
Publisher: Springer Science & Business Media
ISBN: 9400758812
Category : Medical
Languages : en
Pages : 269

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The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241565632
Category : Medical
Languages : en
Pages : 472

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The report provides an overview of alcohol consumption and harms in relation to the UN Sustainable Development Goals (Chapter 1) presents global strategies action plans and monitoring frameworks (Chapter 2) gives detailed information on: the consumption of alcohol in populations (Chapter 3); the health consequences of alcohol consumption (Chapter 4); and policy responses at national level (Chapter 5). In its final chapter 6 the imperative for reducing harmful use of alcohol in a public health perspective is presented. In addition the report contains country profiles for WHO Member States and appendices with statistical annexes a description of the data sources and methods used to produce the estimates and references.

Author: Ronald Ross Watson
Publisher: Academic Press
ISBN: 012814467X
Category : Science
Languages : en
Pages : 430

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Dietary Interventions in Liver Disease: Foods, Nutrients, and Dietary Supplements provides valuable insights into the agents that affect metabolism and other health-related conditions in the liver. It provides nutritional treatment options for those suffering from liver disease. Information is presented on a variety of foods, including herbs, fruits, soy and olive oil, thus illustrating that variations in intake can change antioxidant and disease preventing non-nutrients that affect liver health and/or disease promotion. This book is a valuable resource for biomedical researchers who focus on identifying the causes of liver diseases and food scientists targeting health-related product development. - Provides information on agents that affect metabolism and other health-related conditions in the liver - Explores the impact of composition, including differences based on country of origin and processing techniques - Addresses the most positive results from dietary interventions using bioactive foods to impact liver disease, including reduction of inflammation and improved function

Author: Robinson Ramírez-Vélez
Publisher: Frontiers Media SA
ISBN: 2889630633
Category :
Languages : en
Pages : 130

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