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Author: P. Bouverot Publisher: Springer Science & Business Media ISBN: 3642823165 Category : Science Languages : en Pages : 188
Book Description
Adaptation to altitude hypoxia is characterized by a variety offunctional changes which collectively facilitate oxygen trans port from the ambient medium to the cells of the body. All of these changes can be seen at one time or another in the course of hypoxic exposure. Yet, as already stressed (Hannon and Vogel, 1977), an examination of the literature gives only a sketchy and often conflicting picture of the exact nature of these changes and how they interact as a function of exposure duration. This is partly because of the limited number of variables explored in a given study, but it is also attributable to differences in experimental design, differences among species in susceptibility to hypoxia, nonstandardized experimental conditions, lack of proper control of physical (e. g. , temperature) and physiological variables (e. g. , body mass), failure to take measurements at key periods of exposure, and gaps in knowledge about some fundamental mechanisms. Furthermore the available data on animals native to high altitude are meager and/or inconclusive. Extensive further work under well-controlled experimental conditions is required before a detailed picture can be made. Nevertheless, it has been a guiding principle in the prepara tion of this monograph rather to summarize the vastly dis persed material that constitutes the comparative physiology of adaptation to high altitude into a coherent picture, than to provide a comprehensive survey of the field.
Author: P. Bouverot Publisher: Springer Science & Business Media ISBN: 3642823165 Category : Science Languages : en Pages : 188
Book Description
Adaptation to altitude hypoxia is characterized by a variety offunctional changes which collectively facilitate oxygen trans port from the ambient medium to the cells of the body. All of these changes can be seen at one time or another in the course of hypoxic exposure. Yet, as already stressed (Hannon and Vogel, 1977), an examination of the literature gives only a sketchy and often conflicting picture of the exact nature of these changes and how they interact as a function of exposure duration. This is partly because of the limited number of variables explored in a given study, but it is also attributable to differences in experimental design, differences among species in susceptibility to hypoxia, nonstandardized experimental conditions, lack of proper control of physical (e. g. , temperature) and physiological variables (e. g. , body mass), failure to take measurements at key periods of exposure, and gaps in knowledge about some fundamental mechanisms. Furthermore the available data on animals native to high altitude are meager and/or inconclusive. Extensive further work under well-controlled experimental conditions is required before a detailed picture can be made. Nevertheless, it has been a guiding principle in the prepara tion of this monograph rather to summarize the vastly dis persed material that constitutes the comparative physiology of adaptation to high altitude into a coherent picture, than to provide a comprehensive survey of the field.
Author: Erik R. Swenson Publisher: Springer Science & Business Media ISBN: 1461487722 Category : Medical Languages : en Pages : 495
Book Description
Over the last decade the science and medicine of high altitude and hypoxia adaptation has seen great advances. High Altitude: Human Adaptation to Hypoxia addresses the challenges in dealing with the changes in human physiology and the particular medical conditions that arise from exposure to high altitude. In-depth and comprehensive chapters cover both the basic science and the clinical consequences of exposure to high altitude. Genetic, cellular, organ and whole body system responses to high altitudes are covered and chapters discuss these effects on a wide range of diseases. Expert authors provide insight into the care of patients with pre-existing medical conditions that fail in some cases to adapt as well as offer insights into how high altitude research can help critically ill patients. High Altitude: Human Adaptation to Hypoxia is an important new volume that offers a window into greater understanding and more successful treatment of hypoxic human diseases.
Author: Robert C. Roach Publisher: Springer Science & Business Media ISBN: 9780306466960 Category : Medical Languages : en Pages : 466
Book Description
Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia. Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.
Author: Jay F. Storz Publisher: ISBN: 0198810687 Category : Medical Languages : en Pages : 258
Book Description
Provides a synthesis of our current understanding of hemoglobin (Hb) function and evolution, and illustrates how research on this protein has provided more general insights into mechanisms of protein evolution and biochemical adaptation.
Author: Göran E. Nilsson Publisher: Cambridge University Press ISBN: 1139485350 Category : Science Languages : en Pages : 351
Book Description
How do vertebrates get the oxygen they need, or even manage without it for shorter or longer periods of time? How do they sense oxygen, how do they take it up from water or air, and how do they transport it to their tissues? Respiratory system adaptations allow numerous vertebrates to thrive in extreme environments where oxygen availability is limited or where there is no oxygen at all. Written for students and researchers in comparative physiology, this authoritative summary of vertebrate respiratory physiology begins by exploring the fundamentals of oxygen sensing, uptake and transport in a textbook style. Subsequently, the reader is shown important examples of extreme respiratory performance, like diving and high altitude survival in mammals and birds, air breathing in fish, and those few vertebrates that can survive without any oxygen at all for several months, showing how evolution has solved the problem of life without oxygen.
Author: Pater W. Hochachka Publisher: Princeton University Press ISBN: 1400855411 Category : Science Languages : en Pages : 559
Book Description
This book discusses biochemical adaptation to environments from freezing polar oceans to boiling hot springs, and under hydrostatic pressures up to 1,000 times that at sea level. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Author: Committee on Military Nutrition Research Publisher: National Academies Press ISBN: 0309556775 Category : Technology & Engineering Languages : en Pages : 585
Book Description
This book reviews the research pertaining to nutrient requirements for working in cold or in high-altitude environments and states recommendations regarding the application of this information to military operational rations. It addresses whether, aside from increased energy demands, cold or high-altitude environments elicit an increased demand or requirement for specific nutrients, and whether performance in cold or high-altitude environments can be enhanced by the provision of increased amounts of specific nutrients.
Author: Shyamala Dakshinamurti Publisher: CRC Press ISBN: 1000442322 Category : Medical Languages : en Pages : 268
Book Description
We have all been hypoxic. Fetal tolerance for intrauterine hypoxia arises from evolutionarily conserved physiological mechanisms, the antecedents of which can be learned from diving mammals or species at high altitudes. Understanding fetal hypoxia leads to understanding the huge physiological shifts of neonatal transition and the dangers of perinatal hypoxia. This comprehensive volume of topical review articles by expert authors addresses the origins of hypoxia tolerance, the impact of oxygen on circulatory transition at birth, and the biochemistry of hypoxia in the pulmonary circuit, as well as the classification, diagnosis, and clinical management of hypoxic respiratory failure and persistent pulmonary hypertension in the term neonate. The goal of Hypoxic Respiratory Failure in the Newborn is to connect our understanding of hypoxia from animals in extreme environments, with how the human fetus handles its hypoxic environment; and why the human newborn suddenly cannot. The book will educate health care professionals on how to care for newborns with hypoxic respiratory failure, including the use of up-to-date diagnostic tools and therapies. It also highlights areas of controversy and ongoing research in hypoxic respiratory failure and pulmonary hypertension of the newborn, including challenging case studies. Key Features Explores evolutionary context and comparative physiology of hypoxia tolerance in the fetus and neonate, from basic research to clinical scenarios Provides guidance to trainees, physicians, and allied health professionals engaged in NICU care; pediatricians, cardiologists, pulmonologists, anesthesiologists, neonatologists, and physiologists to effectively manage infants in hypoxic respiratory failure Includes case scenarios emphasizing current diagnostic and therapeutic controversies and algorithmic approaches to decipher difficult clinical cases
Author: W. Brendel Publisher: Springer Science & Business Media ISBN: 1461256399 Category : Medical Languages : en Pages : 322
Book Description
High altitude physiology and medicine has again become important. The excep tional achievements of mountaineers who have climbed nearly all peaks over 8,000 m without breathing equipment raise the question of maximal adaptation ca pacity of man to low oxygen pressures. More importantly, the increase in tourism in the Andes and the Himalayas brings over 10,000 people to sites at altitudes above 4,000 and 5,000 m each year. At such heights several kinds of high alti tude diseases are likely to occur, and these complications require detailed medical investigations. Medical authorities need to inform both mountaineers and tourists as to how great a physical burden can be taken in the mountain environment without risk to health. Physicians need to know what kind of prophylaxis is to be employed at high altitudes to prevent the development of diseases and what therapeutic measures should be used once high altitude diseases have occurred. Moreover, the physical condition of the indigenous population living at higher altitudes such as the Andes and the Himalayas, who are exposed continuously to the stress of high altitude, requires our attention. We have become familiar with symptoms characteristic of chronic high-altitude disease: under special conditions this popu lation has a tendency to develop pulmonary hypertension, which is associated with pulmonary edema, pulmonary congestion, and right heart failure.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309172764 Category : Medical Languages : en Pages : 303
Book Description
The activities of the Food and Nutrition Board's Committee on Military Nutrition Research (CMNR, the committee) have been supported since 1994 by grant DAMD17-94-J-4046 from the U.S. Army Medical Research and Materiel Command (USAMRMC). This report fulfills the final reporting requirement of the grant, and presents a summary of activities for the grant period from December 1, 1994 through May 31, 1999. During this grant period, the CMNR has met from three to six times each year in response to issues that are brought to the committee through the Military Nutrition and Biochemistry Division of the U.S. Army Research Institute of Environmental Medicine at Natick, Massachusetts, and the Military Operational Medicine Program of USAMRMC at Fort Detrick, Maryland. The CMNR has submitted five workshop reports (plus two preliminary reports), including one that is a joint project with the Subcommittee on Body Composition, Nutrition, and Health of Military Women; three letter reports, and one brief report, all with recommendations, to the Commander, U.S. Army Medical Research and Materiel Command, since September 1995 and has a brief report currently in preparation. These reports are summarized in the following activity report with synopses of additional topics for which reports were deferred pending completion of military research in progress. This activity report includes as appendixes the conclusions and recommendations from the nine reports and has been prepared in a fashion to allow rapid access to committee recommendations on the topics covered over the time period.
Author: P. Bouverot
Author: P. Bouverot
Author: Erik R. Swenson
Author: Robert C. Roach
Author: Jay F. Storz
Author: Göran E. Nilsson
Author: Pater W. Hochachka
Author: Committee on Military Nutrition Research
Author: Shyamala Dakshinamurti
Author: W. Brendel
Author: Institute of Medicine