The Mega-fun Multiplication Facts Activity Book PDF Download

Author: Marcia Miller
Publisher: Scholastic Inc.
ISBN: 9780590373500
Category : Education
Languages : en
Pages : 76

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Book Description
Easy games, poems, mini-books, reproducible, and memorization strategies for kids of all learning styles.

Author: Pier Luigi Mazzeo
Publisher: Springer
ISBN: 3319133233
Category : Computers
Languages : en
Pages : 124

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Book Description
This book constitutes the thoroughly refereed post-conference proceedings of the Second International Workshop on Activity Monitoring by Multiple Distributed Sensing, AMMDS 2014, held in Stockholm, Sweden, in August 2014, as a satellite event of ICPR 2014, the 22nd International Conference on Pattern Recognition. The 9 revised full papers included in the volume investigate the challenges that arise when distributed sensor networks are used to track, monitor, and understand the activity, intent, and motives of human beings. Application areas include human-computer interaction, user interface design, robot learning, and surveillance.

Author: Irene Håkansson
Publisher: Linköping University Electronic Press
ISBN: 9176850129
Category :
Languages : en
Pages : 85

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Book Description
This thesis focuses on disease activity in clinically isolated syndrome (CIS) and newly diagnosed relapsing remitting multiple sclerosis (RRMS). The papers are based on data from 41 patients in a prospective longitudinal cohort study. All patients were untreated at baseline. Age- and sex-matched healthy controls (n=22) for blood and cerebrospinal fluid (CSF) samples were recruited from blood donors. Paper I evaluated the prognostic value of baseline levels of CXCL1, CXCL8, CXCL10, CXCL13, CCL22, neurofilament light chain (NFL), neurofilament heavy chain, glial fibrillary acidic protein, chitinase-3-like-1 (CHI3L1), matrix metalloproteinase-9 (MMP-9) and osteopontin in CSF in relation to disease activity during the first two years of follow-up. Disease activity was defined as clinical relapses, new T2 lesions in brain magnetic resonance imaging (MRI) and/or sustained Expanded Disability Status Scale (EDSS) progression. Absence of these three signs of disease activity was called no evidence of disease activity (NEDA-3). Logistic regression analysis showed that NFL in CSF was the best predictive marker of disease activity and correctly classified 93% of the patients with evidence of disease activity during two years of follow-up and 67% of those without. Paper II presented four year follow-up data from the cohort and also included brain volume data as well as serum levels of NFL. The correlation between NFL in CSF and serum was fairly strong (r=0.74, p<0.001). NFL in CSF was associated with new T2 lesions as well as with brain volume loss, whereas CHI3L1 in CSF was associated mainly with brain volume loss and CXCL1, CXCL10, CXCL13, CCL22 and MMP-9 in CSF were mainly associated with new T2 lesions. Taken together, paper I and II confirm and extend the knowledge of NFL as a useful biomarker in CIS and RRMS and suggests that NFL, rather than total brain volume loss, could be included in an expanded NEDA concept and used in clinical monitoring of disease activity/treatment effect. Although serum levels of NFL were correlated with the corresponding CSF levels, CSF-NFL showed a stronger association to subsequent disease activity (NEDA-3). Paper III addressed the patients´ self-reported Modified Fatigue Impact Scale (MFIS) scores in relation to other cohort study data. MFIS scores correlated with other self-assessment questionnaire data (Hospital Anxiety and Depression scale (HAD), Multiple Sclerosis Impact Scale 29 (MSIS-29) and Short Form 36 (SF-36) scores (Spearman´s rho 0.45-0.78, all p?0.01)) but not with EDSS ratings, number of T2 lesions, total brain volume or NFL levels, indicating that subjective fatigue scores are not well reflected by some commonly used and objectively measurable disease parameters. Paper IV focused on the complement factors C1q, C3, C3a and sC5b-9 in CSF and plasma. CSFC1q was significantly higher in patients than in controls at baseline. The subgroup of patients with ongoing relapse at baseline also had higher levels of CSF-C3a than controls. Baseline levels of CSF-C1q and CSF-C3a correlated significantly with several pro-inflammatory chemokines as well as with MMP-9, CHI3L1 and NFL in CSF. Baseline CSF-C3a also correlated significantly with the number of T2 lesions and Gadolinium enhancing lesions in brain MRI at baseline, as well as with the number of new T2 lesions during follow-up. This study indicates that the complement system is involved already at early stages of MS. It also suggests that especially CSF-C1q and CSF-C3a levels are associated with other neuroinflammatory and neurodegenerative markers and that CSF-C3a levels may carry some prognostic information.

Author: Charlotte Cushman
Publisher: eBookIt.com
ISBN: 0988171309
Category : Education
Languages : en
Pages : 32

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Book Description
This book is intended to be used as a resource for a range of professionals, parents and other caregivers who are working with children with visual and multiple disabilities. Chapter One provides and an overview of teaching strategies for this population and guidelines to be used in ensuring that the instruction is successful.

Author: Rosanna Chianese
Publisher: Frontiers Media SA
ISBN: 2889457362
Category :
Languages : en
Pages : 120

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Book Description
In 1996 a cDNA called KISS1 (KI in reference to the place of discovery-Hershey Pennsylvania, home of the famous Hershey Chocolate Kisses- and SS as suppressor sequence) was identified in non-metastatic melanoma cell lines. Its 54 amino-acid product, Kisspeptin-54 (Kp-54), was originally called metastin for its ability to inhibit cancer metastasis through the activation of a G coupled receptor, previously known as GPR54 and currently renamed the Kisspeptin receptor (KISS1R). Shorter active peptides all capable of binding to KISS1R have been identified and the physiological activities of these Kisspeptins are now known to extend not only to the suppression of metastasis. Kisspeptins currently represent evolutionarily conserved biological modulators, with a recognized role in the central control of sex maturation, reproduction and fertility. Consequently, the focus on the central role of the Kisspeptins has led to neglecting their possible activities in peripheral tissues. Increasing data reveals that Kisspeptins and KISS1R have a wider expression and possibly a broader spectrum of action in several peripheral tissues such as the gonads, adipose tissue, and liver with direct consequences on gamete quality and fertility rate, pregnancy, energy homeostasis and body weight control. In this respect, the Kisspeptin system may represent a promising prognostic/diagnostic biomarker and therapeutic target for cancer and other human diseases such as infertility and metabolic disorders. This Research Topic provides a comprehensive picture of the recognized and the emerging role of the Kisspeptin system. Such a volume is very timely and useful to the wide community of researchers in the field and for the scientific community at large.

Author: Anonymous
Publisher: Palala Press
ISBN:
Category : History
Languages : en
Pages : 516

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Book Description
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Author: Cornelis Winkler
Publisher:
ISBN:
Category :
Languages : en
Pages : 764

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Author: Jack M. Winters
Publisher: Springer Science & Business Media
ISBN: 1461390303
Category : Science
Languages : en
Pages : 818

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Book Description
The picture on the front cover of this book depicts a young man pulling a fishnet, a task of practical relevance for many centuries. It is a complex task, involving load transmission throughout the body, intricate balance, and eye head-hand coordination. The quest toward understanding how we perform such tasks with skill and grace, often in the presence of unpredictable pertur bations, has a long history. However, despite a history of magnificent sculptures and drawings of the human body which vividly depict muscle ac tivity and interaction, until more recent times our state of knowledge of human movement was rather primitive. During the past century this has changed; we now have developed a considerable database regarding the com position and basic properties of muscle and nerve tissue and the basic causal relations between neural function and biomechanical movement. Over the last few decades we have also seen an increased appreciation of the impor tance of musculoskeletal biomechanics: the neuromotor system must control movement within a world governed by mechanical laws. We have now col lected quantitative data for a wealth of human movements. Our capacity to understand the data we collect has been enhanced by our continually evolving modeling capabilities and by the availability of computational power. What have we learned? This book is designed to help synthesize our current knowledge regarding the role of muscles in human movement. The study of human movement is not a mature discipline.

Author: African Institute for Mathematical Sciences Schools Enrichment Centre
Publisher: Cambridge University Press
ISBN: 1316503623
Category : Education
Languages : en
Pages : 209

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Book Description
This series is for maths teachers who want to develop their maths teaching skills. This book is for teachers and educators who want to develop their maths teaching skills where English is the language of instruction. It has been written by the international group of educators based at AIMSSEC, The African Institute for Mathematical Sciences Schools Enrichment Centre. The book provides practical classroom activities underpinned by sound pedagogy and recent research findings. The activities are designed for teachers working alone or in 'self-help' teachers' workshops. They are designed to develop mathematical thinking and offer immediate practical tools to help deliver this approach.

Author: Edward Lee Thorndike
Publisher:
ISBN:
Category : Arithmetic
Languages : en
Pages : 288

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