Author: Publisher:
ISBN:
Category : Mathematics
Languages : en
Pages : 1608
Book Description
Mathematical Reviews
Author: Inverse Problems, Control and Modeling in the Presence of Uncertainty
Author: Harvey Thomas BanksPublisher:
ISBN:
Category : Inverse problems (Differential equations)
Languages : en
Pages : 42
Book Description
We report progress on the development of methods in a number of specific areas of application including static, non-cooperative games related to counter- and counter-counter-electromagnetic interrogation of targets, modeling of complex viscoelastic polymeric materials, stochastic and deterministic models for complex networks and development of inverse problem methodologies (generalized sensitivity functions; asymptotic standard errors) for estimation of infinite dimensional functional parameters including probability measures and temporal/spatial dependent functions in complex nonlinear dynamical systems. These efforts are part of our fundamental research in a modeling, estimation and control methodology (theoretical, statistical and computational) for systems in the presence of major model and observation uncertainties.
Environmental Health Perspectives
Author: Publisher:
ISBN:
Category : Environmental health
Languages : en
Pages : 1108
Book Description
Handbook of Bioequivalence Testing
Author: Sarfaraz K. NiaziPublisher: CRC Press
ISBN: 0849383595
Category : Medical
Languages : en
Pages : 602
Book Description
As the generic pharmaceutical industry continues to grow and thrive, so does the need to conduct efficient and successful bioequivalence studies. In recent years, there have been significant changes to the statistical models for evaluating bioequivalence, and advances in the analytical technology used to detect drug and metabolite levels have made
Cumulated Index Medicus
Author: Index Medicus
Author: Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1736
Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Handbook of Bioequivalence Testing, Second Edition
Author: Sarfaraz K. NiaziPublisher: CRC Press
ISBN: 1482226375
Category : Medical
Languages : en
Pages : 1012
Book Description
As the generic pharmaceutical industry continues to grow and thrive, so does the need to conduct adequate, efficient bioequivalence studies. In recent years, there have been significant changes to the statistical models for evaluating bioequivalence. In addition, advances in the analytical technology used to detect drug and metabolite levels have made bioequivalence testing more complex. The second edition of Handbook of Bioequivalence Testing has been completely updated to include the most current information available, including new findings in drug delivery and dosage form design and revised worldwide regulatory requirements. New topics include: A historical perspective on generic pharmaceuticals New guidelines governing submissions related to bioequivalency studies, along with therapeutic code classifications Models of noninferiority Biosimilarity of large molecule drugs Bioequivalence of complementary and alternate medicines Bioequivalence of biosimilar therapeutic proteins and monoclonal antibodies New FDA guidelines for bioanalytical method validation Outsourcing and monitoring of bioequivalence studies The cost of generic drugs is rising much faster than in the past, partly because of the increased costs required for approval—including those for bioequivalence testing. There is a dire need to re-examine the science behind this type of testing to reduce the burden of development costs—allowing companies to develop generic drugs faster and at a lower expense. The final chapter explores the future of bioequivalence testing and proposes radical changes in the process of biowaivers. It suggests how the cost of demonstrating bioequivalence can be reduced through intensive analytical investigation and proposes that regulatory agencies reduce the need for bioequivalence studies in humans. Backed by science and updated with the latest research, this book is destined to spark continued debate on the efficacy of the current bioequivalence testing paradigm.
Pharmacokinetic-Pharmacodynamic Modeling and Simulation
Author: Peter L. BonatePublisher: Springer Science & Business Media
ISBN: 0387271996
Category : Medical
Languages : en
Pages : 395
Book Description
A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops in that manner – each chapter builds upon previous chapters by first presenting the theory and then illustrating the theory using published data sets and actual data sets that were used in the development of new chemical entities collected by the author during his years in industry. A key feature of the book is the process of modeling. Most books and manuscripts often present the final model never showing how the model evolved. In this book all examples are presented in an evolutionary manner.
Individualized Drug Therapy for Patients
Author: Roger W JelliffePublisher: Academic Press
ISBN: 0128033495
Category : Computers
Languages : en
Pages : 435
Book Description
Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient. - 2018 PROSE Awards - Honorable Mention, Clinical Medicine: Association of American Publishers - Uses pharmacokinetic approaches as the tools with which therapy is individualized - Provides examples using specific software that illustrate how best to apply these approaches and to make sense of the more sophisticated mathematical foundations upon which this book is based - Incorporates clinical cases throughout to illustrate the real-world benefits of using these approaches - Focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal
Parameter Estimation in Model Analysis and Controller Design
Author: Hsuehmin LiPublisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 356
Book Description