Author: Andrey V. Solov’yov
Publisher: Springer
ISBN: 3319430300
Category : Science
Languages : en
Pages : 508
Book Description
This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide. The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development in cancer therapy. The full potential of such therapy can only be realized by better understanding the physical, chemical and biological mechanisms, on a range of time and space scales that lead to cell death under ion irradiation. This book describes how, using a multiscale approach, experimental and theoretical expertise available can lead to greater insight at the nanoscopic and molecular level into radiation damage of biological targets induced by ion impact. The book is intended for advanced students and specialists in the areas of physics, chemistry, biology and medicine related to ion-beam therapy, radiation protection, biophysics, radiation nanophysics and chemistry, atomic and molecular physics, condensed matter physics, and the physics of interaction of charged particles with matter. One of the most important features of the book is the inclusive multiscale approach to the understanding of complex and highly interdisciplinary processes behind ion-beam cancer therapy, which stretches from the atomistic level up to the biological scale and is demonstrated to be in excellent agreement with experimental observations.
Nanoscale Insights into Ion-Beam Cancer Therapy
Author: Andrey V. Solov’yov
Publisher: Springer
ISBN: 3319430300
Category : Science
Languages : en
Pages : 508
Book Description
This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide. The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development in cancer therapy. The full potential of such therapy can only be realized by better understanding the physical, chemical and biological mechanisms, on a range of time and space scales that lead to cell death under ion irradiation. This book describes how, using a multiscale approach, experimental and theoretical expertise available can lead to greater insight at the nanoscopic and molecular level into radiation damage of biological targets induced by ion impact. The book is intended for advanced students and specialists in the areas of physics, chemistry, biology and medicine related to ion-beam therapy, radiation protection, biophysics, radiation nanophysics and chemistry, atomic and molecular physics, condensed matter physics, and the physics of interaction of charged particles with matter. One of the most important features of the book is the inclusive multiscale approach to the understanding of complex and highly interdisciplinary processes behind ion-beam cancer therapy, which stretches from the atomistic level up to the biological scale and is demonstrated to be in excellent agreement with experimental observations.
Publisher: Springer
ISBN: 3319430300
Category : Science
Languages : en
Pages : 508
Book Description
This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide. The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development in cancer therapy. The full potential of such therapy can only be realized by better understanding the physical, chemical and biological mechanisms, on a range of time and space scales that lead to cell death under ion irradiation. This book describes how, using a multiscale approach, experimental and theoretical expertise available can lead to greater insight at the nanoscopic and molecular level into radiation damage of biological targets induced by ion impact. The book is intended for advanced students and specialists in the areas of physics, chemistry, biology and medicine related to ion-beam therapy, radiation protection, biophysics, radiation nanophysics and chemistry, atomic and molecular physics, condensed matter physics, and the physics of interaction of charged particles with matter. One of the most important features of the book is the inclusive multiscale approach to the understanding of complex and highly interdisciplinary processes behind ion-beam cancer therapy, which stretches from the atomistic level up to the biological scale and is demonstrated to be in excellent agreement with experimental observations.
Polarization Bremsstrahlung
Author: Andrey V. Korol
Publisher: Springer Science & Business Media
ISBN: 3642452248
Category : Science
Languages : en
Pages : 285
Book Description
This book introduces and reviews both theory and applications of polarizational bremsstrahlung, i.e. the electromagnetic radiation emitted during collisions of charged particles with structured, thus polarizable targets, such as atoms, molecules and clusters. The subject, following the first experimental evidence a few decades ago, has gained importance through a number of modern applications. Thus, the study of several radiative mechanisms is expected to lead to the design of novel light sources, operating in various parts of the electromagnetic spectrum. Conversely, the analysis of the spectral and angular distribution of the photon emission constitutes a new tool for extracting information on the interaction of the colliding particles, and on their internal structure and dynamical properties. Last but not least, accurate quantitative descriptions of the photon emission processes determine the radiative energy losses of particles in various media, thereby providing essential information required for e.g. plasma diagnostics as well as astrophysical and medical applications (such as radiation therapy). This book primarily addresses graduate students and researchers with a background in atomic, molecular, optical or plasma physics, but will also be of benefit to anyone wishing to enter the field.
Publisher: Springer Science & Business Media
ISBN: 3642452248
Category : Science
Languages : en
Pages : 285
Book Description
This book introduces and reviews both theory and applications of polarizational bremsstrahlung, i.e. the electromagnetic radiation emitted during collisions of charged particles with structured, thus polarizable targets, such as atoms, molecules and clusters. The subject, following the first experimental evidence a few decades ago, has gained importance through a number of modern applications. Thus, the study of several radiative mechanisms is expected to lead to the design of novel light sources, operating in various parts of the electromagnetic spectrum. Conversely, the analysis of the spectral and angular distribution of the photon emission constitutes a new tool for extracting information on the interaction of the colliding particles, and on their internal structure and dynamical properties. Last but not least, accurate quantitative descriptions of the photon emission processes determine the radiative energy losses of particles in various media, thereby providing essential information required for e.g. plasma diagnostics as well as astrophysical and medical applications (such as radiation therapy). This book primarily addresses graduate students and researchers with a background in atomic, molecular, optical or plasma physics, but will also be of benefit to anyone wishing to enter the field.
Promoting Psychological Resilience in the U.S. Military
Author: Lisa S. Meredith
Publisher: Rand Corporation
ISBN: 0833058169
Category : Medical
Languages : en
Pages : 185
Book Description
As U.S. service members deploy for extended periods on a repeated basis, their ability to cope with the stress of deployment may be challenged. Many programs are available to encourage and support psychological resilience among service members and families. However, little is known about these programs' effectiveness. This report reviews resilience literature and programs to identify evidence-informed factors for promoting resilience.
Publisher: Rand Corporation
ISBN: 0833058169
Category : Medical
Languages : en
Pages : 185
Book Description
As U.S. service members deploy for extended periods on a repeated basis, their ability to cope with the stress of deployment may be challenged. Many programs are available to encourage and support psychological resilience among service members and families. However, little is known about these programs' effectiveness. This report reviews resilience literature and programs to identify evidence-informed factors for promoting resilience.
Financial Freedom
Author: Reuben Advani
Publisher: Apress
ISBN: 1430245409
Category : Business & Economics
Languages : en
Pages : 151
Book Description
If you're one of the millions of Americans who is buried in credit card debt, or maybe you're having trouble deciphering the fine print on your 401(K)—that is, if you even have a 401(K)!—don't dismay. You can start taking steps toward closing your financial illiteracy gap right away with the sound, practical personal finance advice offered up in Reuben Advani's Financial Freedom. Designed for young adult professionals but filled with crucial information that will financially empower readers of all ages, Financial Freedom is more than just your standard personal finance book, which offers up plenty of encouragement but very little actionable advice. Instead, this user-friendly guide stands alone thanks to the clear approach it takes to the topic of personal finance. So, no matter whether you are in the market for a new car, are looking to become a first-time homeowner, want to save up for your child's college education, or have decided to try your hand at investing, you'll find engaging, nonjudgmental answers to your most pressing financial questions in this invaluable resource. Jam-packed with financial guidance yet presented in a gentle, humorous manner, Financial Freedom will teach you: The ins and outs of the world of finance, including targeted advice on how to use its tools to create a better financial future for yourself; The difference between good debt and bad debt—as well as tips and hints for avoiding the latter of the two; The low-down on mortgages, auto loans, student loans, and credit cards; Strategies and techniques for investing in stocks, bonds, and real estate; And much more. When it comes to securing your financial future, building a strong foundation of financial knowledge and skills is the smartest thing you can do. Put yourself on the path to long-term financial literacy, independence, and success with Financial Freedom, which provides all the information you need to make sound financial decisions for a lifetime.
Publisher: Apress
ISBN: 1430245409
Category : Business & Economics
Languages : en
Pages : 151
Book Description
If you're one of the millions of Americans who is buried in credit card debt, or maybe you're having trouble deciphering the fine print on your 401(K)—that is, if you even have a 401(K)!—don't dismay. You can start taking steps toward closing your financial illiteracy gap right away with the sound, practical personal finance advice offered up in Reuben Advani's Financial Freedom. Designed for young adult professionals but filled with crucial information that will financially empower readers of all ages, Financial Freedom is more than just your standard personal finance book, which offers up plenty of encouragement but very little actionable advice. Instead, this user-friendly guide stands alone thanks to the clear approach it takes to the topic of personal finance. So, no matter whether you are in the market for a new car, are looking to become a first-time homeowner, want to save up for your child's college education, or have decided to try your hand at investing, you'll find engaging, nonjudgmental answers to your most pressing financial questions in this invaluable resource. Jam-packed with financial guidance yet presented in a gentle, humorous manner, Financial Freedom will teach you: The ins and outs of the world of finance, including targeted advice on how to use its tools to create a better financial future for yourself; The difference between good debt and bad debt—as well as tips and hints for avoiding the latter of the two; The low-down on mortgages, auto loans, student loans, and credit cards; Strategies and techniques for investing in stocks, bonds, and real estate; And much more. When it comes to securing your financial future, building a strong foundation of financial knowledge and skills is the smartest thing you can do. Put yourself on the path to long-term financial literacy, independence, and success with Financial Freedom, which provides all the information you need to make sound financial decisions for a lifetime.
Latest Advances in Atomic Cluster Collisions
Author: J. P. Connerade
Publisher: World Scientific
ISBN: 1860944957
Category : Science
Languages : en
Pages : 398
Book Description
- The first book covering a broad range of physical and chemical problems of atomic cluster physics in the context of physics of atomic and molecular collisions bull; Contains contributions from leading experts in the field bull; Considers both free and supported cluster systems bull; Provides both a general introduction to the field and describes its very recent developments -- ideal for graduate and post-graduate students new to the area as well as specialists in atomic cluster physics bull; Useful for comprehensive lecture courses in quantum mechanics, condensed matter physics and other courses in which complex finite systems like atoic clusters are relevant
Publisher: World Scientific
ISBN: 1860944957
Category : Science
Languages : en
Pages : 398
Book Description
- The first book covering a broad range of physical and chemical problems of atomic cluster physics in the context of physics of atomic and molecular collisions bull; Contains contributions from leading experts in the field bull; Considers both free and supported cluster systems bull; Provides both a general introduction to the field and describes its very recent developments -- ideal for graduate and post-graduate students new to the area as well as specialists in atomic cluster physics bull; Useful for comprehensive lecture courses in quantum mechanics, condensed matter physics and other courses in which complex finite systems like atoic clusters are relevant
Threatcasting
Author: Brian David Johnson
Publisher: Springer Nature
ISBN: 303102575X
Category : Mathematics
Languages : en
Pages : 285
Book Description
Impending technological advances will widen an adversary’s attack plane over the next decade. Visualizing what the future will hold, and what new threat vectors could emerge, is a task that traditional planning mechanisms struggle to accomplish given the wide range of potential issues. Understanding and preparing for the future operating environment is the basis of an analytical method known as Threatcasting. It is a method that gives researchers a structured way to envision and plan for risks ten years in the future. Threatcasting uses input from social science, technical research, cultural history, economics, trends, expert interviews, and even a little science fiction to recognize future threats and design potential futures. During this human-centric process, participants brainstorm what actions can be taken to identify, track, disrupt, mitigate, and recover from the possible threats. Specifically, groups explore how to transform the future they desire into reality while avoiding an undesired future. The Threatcasting method also exposes what events could happen that indicate the progression toward an increasingly possible threat landscape. This book begins with an overview of the Threatcasting method with examples and case studies to enhance the academic foundation. Along with end-of-chapter exercises to enhance the reader’s understanding of the concepts, there is also a full project where the reader can conduct a mock Threatcasting on the topic of “the next biological public health crisis.” The second half of the book is designed as a practitioner’s handbook. It has three separate chapters (based on the general size of the Threatcasting group) that walk the reader through how to apply the knowledge from Part I to conduct an actual Threatcasting activity. This book will be useful for a wide audience (from student to practitioner) and will hopefully promote new dialogues across communities and novel developments in the area.
Publisher: Springer Nature
ISBN: 303102575X
Category : Mathematics
Languages : en
Pages : 285
Book Description
Impending technological advances will widen an adversary’s attack plane over the next decade. Visualizing what the future will hold, and what new threat vectors could emerge, is a task that traditional planning mechanisms struggle to accomplish given the wide range of potential issues. Understanding and preparing for the future operating environment is the basis of an analytical method known as Threatcasting. It is a method that gives researchers a structured way to envision and plan for risks ten years in the future. Threatcasting uses input from social science, technical research, cultural history, economics, trends, expert interviews, and even a little science fiction to recognize future threats and design potential futures. During this human-centric process, participants brainstorm what actions can be taken to identify, track, disrupt, mitigate, and recover from the possible threats. Specifically, groups explore how to transform the future they desire into reality while avoiding an undesired future. The Threatcasting method also exposes what events could happen that indicate the progression toward an increasingly possible threat landscape. This book begins with an overview of the Threatcasting method with examples and case studies to enhance the academic foundation. Along with end-of-chapter exercises to enhance the reader’s understanding of the concepts, there is also a full project where the reader can conduct a mock Threatcasting on the topic of “the next biological public health crisis.” The second half of the book is designed as a practitioner’s handbook. It has three separate chapters (based on the general size of the Threatcasting group) that walk the reader through how to apply the knowledge from Part I to conduct an actual Threatcasting activity. This book will be useful for a wide audience (from student to practitioner) and will hopefully promote new dialogues across communities and novel developments in the area.
Techno-Societal 2020
Author: Prashant M. Pawar
Publisher: Springer Nature
ISBN: 3030699250
Category : Technology & Engineering
Languages : en
Pages : 1090
Book Description
This book, divided in two volumes, originates from Techno-Societal 2020: the 3rd International Conference on Advanced Technologies for Societal Applications, Maharashtra, India, that brings together faculty members of various engineering colleges to solve Indian regional relevant problems under the guidance of eminent researchers from various reputed organizations. The focus of this volume is on technologies that help develop and improve society, in particular on issues such as advanced and sustainable technologies for manufacturing processes, environment, livelihood, rural employment, agriculture, energy, transport, sanitation, water, education. This conference aims to help innovators to share their best practices or products developed to solve specific local problems which in turn may help the other researchers to take inspiration to solve problems in their region. On the other hand, technologies proposed by expert researchers may find applications in different regions. This offers a multidisciplinary platform for researchers from a broad range of disciplines of Science, Engineering and Technology for reporting innovations at different levels.
Publisher: Springer Nature
ISBN: 3030699250
Category : Technology & Engineering
Languages : en
Pages : 1090
Book Description
This book, divided in two volumes, originates from Techno-Societal 2020: the 3rd International Conference on Advanced Technologies for Societal Applications, Maharashtra, India, that brings together faculty members of various engineering colleges to solve Indian regional relevant problems under the guidance of eminent researchers from various reputed organizations. The focus of this volume is on technologies that help develop and improve society, in particular on issues such as advanced and sustainable technologies for manufacturing processes, environment, livelihood, rural employment, agriculture, energy, transport, sanitation, water, education. This conference aims to help innovators to share their best practices or products developed to solve specific local problems which in turn may help the other researchers to take inspiration to solve problems in their region. On the other hand, technologies proposed by expert researchers may find applications in different regions. This offers a multidisciplinary platform for researchers from a broad range of disciplines of Science, Engineering and Technology for reporting innovations at different levels.
Advanced Steels
Author: Yuqing Weng
Publisher: Springer Science & Business Media
ISBN: 3642176658
Category : Technology & Engineering
Languages : en
Pages : 495
Book Description
"Advanced Steels: The Recent Scenario in Steel Science and Technology" contains more than 50 articles selected from the proceedings of the International Conference on Advanced Steels (ICAS) held during 9-11, Nov, 2010 in Guilin, China. This book covers almost all important aspects of steels from physical metallurgy, steel grades, processing and fabrication, simulation, to properties and applications. The book is intended for researchers and postgraduate students in the field of steels, metallurgy and materials science. Prof. Yuqing Weng is an academician of Chinese Academy of Engineering and the president of The Chinese Society for Metals. Prof. Han Dong is the vice president of Central Iron & Steel Research Institute and the director of National Engineering Research Center of Advanced Steel Technology, China. Prof. Yong Gan is an academician of Chinese Academy of Engineering, the vice president of Chinese Academy of Engineering and the president of Central Iron & Steel Research Institute, China.
Publisher: Springer Science & Business Media
ISBN: 3642176658
Category : Technology & Engineering
Languages : en
Pages : 495
Book Description
"Advanced Steels: The Recent Scenario in Steel Science and Technology" contains more than 50 articles selected from the proceedings of the International Conference on Advanced Steels (ICAS) held during 9-11, Nov, 2010 in Guilin, China. This book covers almost all important aspects of steels from physical metallurgy, steel grades, processing and fabrication, simulation, to properties and applications. The book is intended for researchers and postgraduate students in the field of steels, metallurgy and materials science. Prof. Yuqing Weng is an academician of Chinese Academy of Engineering and the president of The Chinese Society for Metals. Prof. Han Dong is the vice president of Central Iron & Steel Research Institute and the director of National Engineering Research Center of Advanced Steel Technology, China. Prof. Yong Gan is an academician of Chinese Academy of Engineering, the vice president of Chinese Academy of Engineering and the president of Central Iron & Steel Research Institute, China.
Readiness Reporting for an Adaptive Army
Author: Christopher G. Pernin
Publisher: Rand Corporation
ISBN: 9780833080325
Category : History
Languages : en
Pages : 0
Book Description
Examines the Army's readiness reporting system in light of changes experienced by Army units in the past decade, particularly the ability of units to adapt to emerging requirements by adding and training up new capabilities quickly.
Publisher: Rand Corporation
ISBN: 9780833080325
Category : History
Languages : en
Pages : 0
Book Description
Examines the Army's readiness reporting system in light of changes experienced by Army units in the past decade, particularly the ability of units to adapt to emerging requirements by adding and training up new capabilities quickly.
Handbook of Unmanned Aerial Vehicles
Author: Kimon P. Valavanis
Publisher: Springer
ISBN: 9789048197064
Category : Technology & Engineering
Languages : en
Pages : 0
Book Description
The Handbook of Unmanned Aerial Vehicles is a reference text for the academic and research communities, industry, manufacturers, users, practitioners, Federal Government, Federal and State Agencies, the private sector, as well as all organizations that are and will be using unmanned aircraft in a wide spectrum of applications. The Handbook covers all aspects of UAVs, from design to logistics and ethical issues. It is also targeting the young investigator, the future inventor and entrepreneur by providing an overview and detailed information of the state-of-the-art as well as useful new concepts that may lead to innovative research. The contents of the Handbook include material that addresses the needs and ‘know how’ of all of the above sectors targeting a very diverse audience. The Handbook offers a unique and comprehensive treatise of everything one needs to know about unmanned aircrafts, from conception to operation, from technologies to business activities, users, OEMs, reference sources, conferences, publications, professional societies, etc. It should serve as a Thesaurus, an indispensable part of the library for everyone involved in this area. For the first time, contributions by the world’s top experts from academia, industry, government and the private sector, are brought together to provide unique perspectives on the current state-of-the-art in UAV, as well as future directions. The Handbook is intended for the expert/practitioner who seeks specific technical/business information, for the technically-oriented scientists and engineers, but also for the novice who wants to learn more about the status of UAV and UAV-related technologies. The Handbook is arranged in a user-friendly format, divided into main parts referring to: UAV Design Principles; UAV Fundamentals; UAV Sensors and Sensing Strategies; UAV Propulsion; UAV Control; UAV Communication Issues; UAV Architectures; UAV Health Management Issues; UAV Modeling, Simulation, Estimation and Identification; MAVs and Bio-Inspired UAVs; UAV Mission and Path Planning; UAV Autonomy; UAV Sense, Detect and Avoid Systems; Networked UAVs and UAV Swarms; UAV Integration into the National Airspace; UAV-Human Interfaces and Decision Support Systems; Human Factors and Training; UAV Logistics Support; UAV Applications; Social and Ethical Implications; The Future of UAVs. Each part is written by internationally renowned authors who are authorities in their respective fields. The contents of the Handbook supports its unique character as a thorough and comprehensive reference book directed to a diverse audience of technologists, businesses, users and potential users, managers and decision makers, novices and experts, who seek a holistic volume of information that is not only a technical treatise but also a source for answers to several questions on UAV manufacturers, users, major players in UAV research, costs, training required and logistics issues.
Publisher: Springer
ISBN: 9789048197064
Category : Technology & Engineering
Languages : en
Pages : 0
Book Description
The Handbook of Unmanned Aerial Vehicles is a reference text for the academic and research communities, industry, manufacturers, users, practitioners, Federal Government, Federal and State Agencies, the private sector, as well as all organizations that are and will be using unmanned aircraft in a wide spectrum of applications. The Handbook covers all aspects of UAVs, from design to logistics and ethical issues. It is also targeting the young investigator, the future inventor and entrepreneur by providing an overview and detailed information of the state-of-the-art as well as useful new concepts that may lead to innovative research. The contents of the Handbook include material that addresses the needs and ‘know how’ of all of the above sectors targeting a very diverse audience. The Handbook offers a unique and comprehensive treatise of everything one needs to know about unmanned aircrafts, from conception to operation, from technologies to business activities, users, OEMs, reference sources, conferences, publications, professional societies, etc. It should serve as a Thesaurus, an indispensable part of the library for everyone involved in this area. For the first time, contributions by the world’s top experts from academia, industry, government and the private sector, are brought together to provide unique perspectives on the current state-of-the-art in UAV, as well as future directions. The Handbook is intended for the expert/practitioner who seeks specific technical/business information, for the technically-oriented scientists and engineers, but also for the novice who wants to learn more about the status of UAV and UAV-related technologies. The Handbook is arranged in a user-friendly format, divided into main parts referring to: UAV Design Principles; UAV Fundamentals; UAV Sensors and Sensing Strategies; UAV Propulsion; UAV Control; UAV Communication Issues; UAV Architectures; UAV Health Management Issues; UAV Modeling, Simulation, Estimation and Identification; MAVs and Bio-Inspired UAVs; UAV Mission and Path Planning; UAV Autonomy; UAV Sense, Detect and Avoid Systems; Networked UAVs and UAV Swarms; UAV Integration into the National Airspace; UAV-Human Interfaces and Decision Support Systems; Human Factors and Training; UAV Logistics Support; UAV Applications; Social and Ethical Implications; The Future of UAVs. Each part is written by internationally renowned authors who are authorities in their respective fields. The contents of the Handbook supports its unique character as a thorough and comprehensive reference book directed to a diverse audience of technologists, businesses, users and potential users, managers and decision makers, novices and experts, who seek a holistic volume of information that is not only a technical treatise but also a source for answers to several questions on UAV manufacturers, users, major players in UAV research, costs, training required and logistics issues.