Vitamin D and COVID-19 Severity in Hospitalized Older Patients PDF Download

Author: Justin Bouloy
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Book Description
Cette étude visait à évaluer les relations entre le statut et la supplémentation en vitamine D (VitD) et la gravité de la maladie COVID-19 chez les personnes âgées (âge moyen de 78 ans) hospitalisées pour COVID-19. Nous avons mené une étude de cohorte rétrospective observationnelle auprès de 228 patients âgés hospitalisés pendant la première vague de la pandémie de la COVID-19. Les résultats étaient la mortalité à l'hôpital secondaire à la COVID-19 ou une forme sévère de la maladie. Une analyse de régression logistique a été réalisée pour vérifier si la supplémentation en vitamine D avant l'hospitalisation était indépendamment associée à la gravité. Dans cette étude, 46% des patients ont développé une forme sévère et la mortalité globale à l'hôpital était de 15%. Soixante-six (29 %) patients ont reçu un supplément de vitamine D au cours des trois mois précédant le début de l'infection. De plus, la supplémentation en vitamine D était associée à un nombre moindre de formes graves de la COVID-19 (OR = 0,426, p = 0,0135) et d'admissions en unité de soins intensifs (OR = 0,341, p = 0,0076). Comme prévu, l'âge >70 ans, le sexe masculin et l'IMC ≥ 35 kg/m2 étaient des facteurs de risque indépendants pour les formes sévères de la COVID-19. Aucune relation entre les taux sériques de 25(OH)D et la sévérité de la COVID-19 n'a été identifiée. Une supplémentation en Vitamine D prise au cours des 3 mois précédant le début de l'infection pourrait avoir un effet protecteur sur le développement des formes sévères de la maladie chez les personnes âgées.

Author: Alexander Choukèr
Publisher: Springer Nature
ISBN: 3030169960
Category : Medical
Languages : en
Pages : 756

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Book Description
This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author: Cheryl D. Fryar
Publisher:
ISBN:
Category : Cardiovascular system
Languages : en
Pages : 8

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Author: Peter D. O. Davies
Publisher: CRC Press
ISBN: 0429586493
Category : Medical
Languages : en
Pages : 482

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Book Description
Completely updated and revised, Clinical Tuberculosis continues to provide the TB practitioner-whether in public health, laboratory science or clinical practice-with a synoptic and definitive account of the latest methods of diagnosis, treatment and control of this challenging and debilitating disease.New in the Fifth Edition:Gamma interferon-based

Author: Susu M. Zughaier
Publisher: Frontiers Media SA
ISBN: 2889661741
Category : Medical
Languages : en
Pages : 177

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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author: Federica Fogacci
Publisher: MDPI
ISBN: 3036512381
Category : Medical
Languages : en
Pages : 300

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Book Description
Dyslipidemia, and particularly hypercholesterolemia, remains a main cardiovascular disease risk factor, partly reversible with the improvement of life-style, including dietary, habits. Even when a pharmacological treatment is begun, dietary support to lipid-lowering is always desired. This book will provide a selection of new evidence on the possible lipid-lowering effects of some dietary and medicinal plant components, reporting some interesting reviews, experimental data and results from clinical trials. The book is adapted for experts in nutrition but also for all scientists involved in cardiovascular disease prevention.

Author: R.E. Hope-Simpson
Publisher: Springer Science & Business Media
ISBN: 1489923853
Category : Medical
Languages : en
Pages : 257

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Book Description
THE PLAGUE YEARS Mankind has always been fascinated by "origins," and biologists are no exception. Darwin is our most famous example. What is the origin of mankind, of species, of infectious diseases? In the last few years we have seen the emergence and spread of some apparently "new" viruses, such as HIV -1 and the virus causing bovine spongiform encephalomyelopathy. But are these, in fact, entirely new agents, or mutated forms of "old" viruses that have evolved along with us for eons? Edgar Hope-Simpson could not have written this book at a more opportune moment. He is a firm believer in gradual evolution, rather than the sudden arrival of new agents. I suspect that he would also have a naturalist's Darwinian approach for the origin of AIDS. It has been a source of some amazement to me over the years how even the most innovative scientists conform to a current hypothesis. Pioneer thinking comes more easily to persons outside the scientific mainstream. Edgar Hope Simpson has always struck me as a modem-day naturalist of the classic style, observant and perhaps a little maverick in line of thought. Certainly, the central hypothesis propounded in this book will be controversial to many scientists. From his unique citadel, the Epidemiological Research Unit in Cirencester, he has carefully reexamined mortality data from old records as well as new.

Author: Michael F. Holick
Publisher: Springer Science & Business Media
ISBN: 1475728611
Category : Medical
Languages : en
Pages : 456

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Book Description
The Nutrition and Health series of books has as an overriding mission to provide health professionals with texts that are considered essential because each includes: a synthesis of the state of the science; timely, in-depth reviews by the leading researchers in their respective fields; extensive, up-to-date fully annotated reference lists; a detailed index; relevant tables and figures; identification of paradigm shifts and the consequences; of information between chapters, but targeted, inter-chapter refer virtually no overlap rals, suggestions of areas for future research; and balanced, data-driven answers to patient questions that are based on the totality of evidence rather than the findings of any single study. The series volumes are not the outcome of a symposium. Rather, each editor has the potential to examine a chosen area with a broad perspective, both in subject matter as well as in the choice of chapter authors. The international perspective, especially with regard to public health initiatives, is emphasized where appropriate. The editors, whose training is both research and practice oriented, have the opportunity to develop a primary objective for their book, define the scope and focus, and then invite the leading authori ties from around the world to be part of their initiative. The authors are encouraged to provide an overview of the field, discuss their own research, and relate the research de findings to potential human health consequences.

Author: Daniel David Bikle
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Book Description
There is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial. Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status. The free hormone hypothesis states that protein-bound hormones are inactive while unbound hormones are free to influence biological activity. The majority of circulating 25(OH)D and 1,25(OH)2D is tightly bound to vitamin D binding protein (DBP), 10 -15% is bound to albumin, and less than 1% of circulating vitamin D exists in an unbound form. While DBP is relatively stable in most healthy populations, recent studies have shown that there are gene polymorphisms associated with race and ethnicity that could alter DBP levels and binding affinity. Furthermore, in some clinical situations total 25(OH)D levels are altered, and knowing whether DBP is also altered may have implications for diagnosis and treatment. In this Research Topic, we provide a collection of comprehensive research on vitamin D and DBP metabolism among different ethnic population and patients with different diseases.

Author: Martin Kohlmeier
Publisher: Academic Press
ISBN: 0123859018
Category : Technology & Engineering
Languages : en
Pages : 397

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Book Description
Nutrigenetics: Applying the Science of Personal Nutrition provides a fully referenced, readable guide to understanding the rationale and importance of nutrigenetic applications and explains why single nutrition recommendations will not fit everybody or even a majority of modern humans. This books explains how genetic variation shapes individual nutrition requirements and sensitivities, presents questions to ask about reported gene-nutrient interactions, and what needs to be done before putting nutrigenetic tests to practical use. This book blends key concepts from the fields of genetics, biochemistry, epidemiology, public health, and clinical medicine to give a rich perspective on the genetically diverse nutritional needs and sensitivities of individuals in health and disease. A steadily increasing number of people order genetic tests to find out what they should eat for better health, well being and performance, and an even greater number asks their healthcare providers about such tests. Most of the currently offered tests are not grounded in current knowledge, often absurdly so, but few professionals can explain why they are misguided. On the other hand, there are more evidence-supported genetic variants that can guide nutrition decisions, but again most healthcare providers know little about them, much less use them in their daily practice. There is a great need for a solidly evidence-based yet accessible book that explains the science of nutrigenetics and provides the tools to evaluate new nutrigenetic tests. - Comprehensive coverage of the emerging science of nutritional genetics and its promise for individually tailored nutrition guidance - Presents practical examples to enhance comprehension and spur additional research - Offers a logical progression from what nutrigenetics is, to its possibilities in enhancing health