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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 1196

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Author: Edward R. Zartler
Publisher: John Wiley & Sons
ISBN: 0470721561
Category : Science
Languages : en
Pages : 296

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Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and contributions from industry. Topics covered include: an introduction to fragment based drug discovery, why using fragments is a more efficient process than predominant models, and what it means to have a successful FBDD effort. setting up an FBDD project library building and production NMR in fragment screening and follow up application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses target immobilized NMR screening: validation and extension to membrane proteins in situ fragment-based medicinal chemistry: screening by mass spectrometry computational approaches to fragment and substructure discovery and evaluation virtual fragment scanning: current trends, applications and web based tools fragment-based lead discovery using covalent capture methods case study from industry: the identification of high affinity beta-secretase inhibitors using fragment-based lead generation With contributions from industry experts who have successfully set up an industrial fragment-based research program, Fragment-Based Drug Discovery: A Practical Approach offers essential advice to anyone embarking on drug discovery using fragments and those looking for a new approach to screening for drugs.

Author: Lionel Fanthorpe
Publisher: Dundurn
ISBN: 9780888822024
Category : Reference
Languages : en
Pages : 244

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This is a collection of remarkable and mysterious people, from all ages and places, including our own.

Author: P. Ramadass
Publisher: MJP Publisher
ISBN:
Category : Science
Languages : en
Pages : 381

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CLONINGGENOME ORGANIZATIONTOOLS FOR GENE CLONINGGENE IDENTIFICATION AND DNA LIBRARIESSTUDYING GENE EXPRESSION AND FUNCTIONPRODUCTION OF PROTEINS FROM CLONED GENESGENE PHARMINGPRODUCTION AND USES OF TRANSGENIC ORGANISMSGENE THERAPYGENE CLONING IN AGRICULTUREFORENSIC AND MEDICAL APPLICATIONS OF GENE CLONINGAPPLICATIONS OF RECOMBINANT DNA TECHNOLOGYREPRODUCTIVE CLONINGTHERAPEUTIC CLONING References

Author: Åslaug Ommundsen
Publisher: Routledge
ISBN: 1317086732
Category : History
Languages : en
Pages : 347

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Much of what is known about the past often rests upon the chance survival of objects and texts. Nowhere is this better illustrated than in the fragments of medieval manuscripts re-used as bookbindings in the sixteenth and seventeenth centuries. Such fragments provide a tantalizing, yet often problematic glimpse into the manuscript culture of the Middle Ages. Exploring the opportunities and difficulties such documents provide, this volume concentrates on the c. 50,000 fragments of medieval Latin manuscripts stored in archives across the five Nordic countries of Denmark, Finland, Iceland, Norway and Sweden. This large collection of fragments (mostly from liturgical works) provides rich evidence about European Latin book culture, both in general and in specific relation to the far north of Europe, one of the last areas of Europe to be converted to Christianity. As the essays in this volume reveal, individual and groups of fragments can play a key role in increasing and advancing knowledge about the acquisition and production of medieval books, and in helping to distinguish locally made books from imported ones. Taking an imaginative approach to the source material, the volume goes beyond a strictly medieval context to integrate early modern perspectives that help illuminate the pattern of survival and loss of Latin manuscripts through post-Reformation practices concerning reuse of parchment. In so doing it demonstrates how the use of what might at first appear to be unpromising source material can offer unexpected and rewarding insights into diverse areas of European history and the history of the medieval book.

Author: Jeff McAffer
Publisher: Addison-Wesley Professional
ISBN: 0321612345
Category : Computers
Languages : en
Pages : 681

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The Definitive Guide to Eclipse Rich Client Development In Eclipse Rich Client Platform, Second Edition, three Eclipse Rich Client Platform (RCP) project leaders show how to use Eclipse 3.5 (“Galileo”) to rapidly deliver cross-platform applications with rich, native-feel GUIs. The authors fully reveal the power of Eclipse as a desktop application development platform; introduce important new improvements in Eclipse 3.5; and walk through developing a full-featured, branded RCP application for Windows, Linux, Mac, and other platforms—including handheld devices and kiosks. Drawing on their extensive experience, the authors cover building, refining, and refactoring prototypes; customizing user interfaces; adding help and software management features; and building, branding, testing, and shipping finished software. They demonstrate current best practices for developing modular and dynamically extensible systems, using third-party code libraries, packaging applications for diverse environments, and much more. For Java programmers at all levels of experience, this book Introduces important new RCP features such as p2, Commands, and Databinding Thoroughly covers key RCP-related technologies such as Equinox, SWT, JFace, and OSGi Shows how to effectively brand and customize RCP application look-and-feel Walks through user interface testing for RCP applications with SWTBot Illuminates key similarities and differences between RCP and conventional plug-in development Hands-on, pragmatic, and comprehensive, this book offers all the real-world, nontrivial code examples working developers need—as well as “deep dives” into key technical areas that are essential to your success.

Author: American Dental Association
Publisher:
ISBN:
Category : Dentistry
Languages : en
Pages : 1172

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Author: Sándor Suhai
Publisher: Springer Science & Business Media
ISBN: 0306468239
Category : Science
Languages : en
Pages : 246

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Genome research will certainly be one of the most important and exciting sci- tific disciplines of the 21st century. Deciphering the structure of the human genome, as well as that of several model organisms, is the key to our understanding how genes fu- tion in health and disease. With the combined development of innovativetools, resources, scientific know-how, and an overall functional genomic strategy, the origins of human and other organisms’geneticdiseases can be traced. Scientificresearch groups and dev- opmental departments of several major pharmaceutical and biotechnological companies are using new, innovative strategies to unravel how genes function, elucidating the gene protein product, understanding how genes interact with others-both in health and in the disease state. Presently, the impact of the applications of genome research on our society in medicine, agriculture and nutrition will be comparable only to that of communication technologies. In fact, computational methods, including networking, have been playing a substantial role even in genomics and proteomics from the beginning. We can observe, however, a fundamental change of the paradigm in life sciences these days: research focused until now mostly on the study of single processes related to a few genes or gene products, but due to technical developments of the last years we can now potentially identify and analyze all genes and gene products of an organism and clarify their role in the network of lifeprocesses.

Author: United States. Surgeon-General's Office
Publisher:
ISBN:
Category :
Languages : en
Pages : 952

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Author: Elizabeth Drayson
Publisher: Bloomsbury Publishing
ISBN: 1788547446
Category : History
Languages : en
Pages : 559

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The essential history of an iconic European city, by Cambridge academic Elizabeth Drayson. 'An admirable achievement... [Drayson has] expertise as a scholar and command as a storyteller' BBC History Magazine 'A glittering homage to one of the world's most beautiful and storied cities' Dan Jones 'Beauty built on blood and brutality... A fascinating new tome' Daily Mail From the early Middle Ages to the present, foreign travellers have been bewitched by Granada's peerless beauty. The Andalusian city is also the stuff of story and legend, with an unforgettable history to match. Romans, then Visigoths, settled here, as did a community of Jews; in the eleventh century a Berber chief made Granada his capital, and from 1230 until 1492 the Nasrids – Spain's last Islamic dynasty – ruled the emirate of Granada from their fortress-palace of the Alhambra. After capturing the city to complete the Christian Reconquista, the Catholic monarchs Ferdinand and Isabella made the Alhambra the site of their royal court. In Lost Paradise, Elizabeth Drayson takes the reader on a voyage of discovery that uncovers the many-layered past of Spain's most complex and fascinating city, celebrating and exploring its evolving identity. Her account brings to the fore the image of Granada as a lost paradise, revealing it as a place of perpetual contradiction and linking it to the great dilemma over Spain's true identity as a nation. This is the story of a vanished Eden, of a place that questions and probes Spain's deep obsession with forgetting, and with erasing historical and cultural memory.