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Author: Dr. Hakim Saboowala Publisher: Dr.Hakim Saboowala ISBN: Category : Medical Languages : en Pages : 69
Book Description
Understanding “LONGEVITY” at Molecular Level. A Comprehensive Review. The more we learn about aging, the more it seems like it might not be an inescapable consequence of life. A striking fact is that aging rates vary dramatically from one species to the other, and from one individual to the other within one species. Some species age so slow that individuals systematically die of starvation, disease, accident or predation before showing any sign of senescence. It is thus tempting to imagine that a better knowledge of the determinants of lifespan could enable us to delay aging Biological causes of aging and lifespan limitation. The more we learn about aging, the more it seems like it might not be an inescapable consequence of life. A striking fact is that aging rates vary dramatically from one species to the other, and from one individual to the other within one species. Some species age so slow that individuals systematically die of: · starvation, · disease, · accident or · predation before showing any sign of senescence. It is thus tempting to imagine that a better knowledge of the determinants of lifespan could enable us to delay aging. Hence, an effort has been made in this Booklet to describe “Longevity” at Molecular Level comprehensively by including several interesting topics (listed in the Table of Content) along with several relevant illustrations for the enthusiastic/ busy Medicos. …Dr. H. K. Saboowala. M.B.(Bom)M.R.S.H.(London)
Author: Dr. Hakim Saboowala Publisher: Dr.Hakim Saboowala ISBN: Category : Medical Languages : en Pages : 69
Book Description
Understanding “LONGEVITY” at Molecular Level. A Comprehensive Review. The more we learn about aging, the more it seems like it might not be an inescapable consequence of life. A striking fact is that aging rates vary dramatically from one species to the other, and from one individual to the other within one species. Some species age so slow that individuals systematically die of starvation, disease, accident or predation before showing any sign of senescence. It is thus tempting to imagine that a better knowledge of the determinants of lifespan could enable us to delay aging Biological causes of aging and lifespan limitation. The more we learn about aging, the more it seems like it might not be an inescapable consequence of life. A striking fact is that aging rates vary dramatically from one species to the other, and from one individual to the other within one species. Some species age so slow that individuals systematically die of: · starvation, · disease, · accident or · predation before showing any sign of senescence. It is thus tempting to imagine that a better knowledge of the determinants of lifespan could enable us to delay aging. Hence, an effort has been made in this Booklet to describe “Longevity” at Molecular Level comprehensively by including several interesting topics (listed in the Table of Content) along with several relevant illustrations for the enthusiastic/ busy Medicos. …Dr. H. K. Saboowala. M.B.(Bom)M.R.S.H.(London)
Author: David A. Sinclair Publisher: Atria Books ISBN: 1501191977 Category : Science Languages : en Pages : 432
Book Description
A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.” —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.
Author: Caleb E. Finch Publisher: ISBN: Category : Health & Fitness Languages : en Pages : 304
Book Description
Demographers and public health specialists have been surprised by the rapid increases in life expectancy, especially at the oldest ages, that have occurred since the early 1960s. Some scientists are calling into question the idea of a fixed upper limit for the human life span. There is new evidence about the genetic bases for both humans and other species. There are also new theories and models of the role of mutations accumulating over the life span and the possible evolutionary advantages of survival after the reproductive years. This volume deals with such diverse topics as the role of the elderly in other species and among human societies past and present, the contribution of evolutionary theory to our understanding of human longevity and intergenerational transfers, mathematical models for survival, and the potential for collecting genetic material in household surveys. It will be particularly valuable for promoting communication between the social and life sciences.
Author: Nicolas Musi Publisher: Academic Press ISBN: 0124116205 Category : Medical Languages : en Pages : 576
Book Description
Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions
Author: Jonathan Sholl Publisher: Springer Nature ISBN: 3030526631 Category : Medical Languages : en Pages : 551
Book Description
This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, and public health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.
Author: Trygve O. Tollefsbol Publisher: Springer Science & Business Media ISBN: 1441906398 Category : Medical Languages : en Pages : 462
Book Description
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
Author: Leonard Guarente Publisher: CSHL Press ISBN: 0879698241 Category : Aging Languages : en Pages : 610
Book Description
This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.
Author: Ray Kurzweil Publisher: Rodale ISBN: 0452286670 Category : Health & Fitness Languages : en Pages : 466
Book Description
A leading scientist and an expert on human longevity explain how new discoveries in the fields of genomics, biotechnology, and nanotechnology could radically extend the human life expectancy and enhance physical and mental abilities, and introduce a cutting-edge program designed to enhance the immune system and slow the aging process on a cellular level. Reprint.
Author: Nozomu Mori Publisher: Springer ISBN: 4431557636 Category : Medical Languages : en Pages : 435
Book Description
This book brings together the most up-to-date information on recent research results of leading laboratories on aging science in East Asia, particularly in Japan, Korea, and Hong Kong. Starting with a comprehensive overview of various hypotheses on biological mechanisms of aging by Dr. Sataro Goto, each chapter covers broad aspects of the most recent findings in aging-related topics: centenarian studies and genome analysis of progeria, metabolic biochemistry and neurobiology, longevity controls in yeast and nematodes, oxidative stress and calorie restriction, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s diseases, with further potential therapeutic approaches to these age-related neurodegenerative diseases. Also included, in part, is a summary and the outcomes of a scientific discussion forum called the Asian Aging Core for Longevity (AACL) that has been held annually alternating between Japan and Korea during the last decade. This book can serve as a useful resource for finding appropriate collaborators in the areas it covers. The target readership is made up of graduate students and researchers at universities, medical and/or life-science schools, and biomedical and pharmaceutical institutes. Why does aging exist? How do we age? How is each organism’s lifespan determined? These are fundamental questions in the field. We may be still far from achieving a complete view of aging mechanisms, but this book, Aging Mechanisms, offers an excellent opportunity to become familiar with the most updated progress in the biomedical research of aging in Japan and Korea, the two leading nations for human longevity.
Author: Dr. Hakim Saboowala
Author: Dr. Hakim Saboowala
Author: David A. Sinclair
Author: Caleb E. Finch
Author: Nicolas Musi
Author: Konrad Beyreuther
Author: Jonathan Sholl
Author: Trygve O. Tollefsbol
Author: Leonard Guarente
Author: Ray Kurzweil
Author: Nozomu Mori