Ultrasound Contrast Agents Loaded with Magnetic Nanoparticles PDF Download

Author:
Publisher:
ISBN: 9789175019512
Category :
Languages : en
Pages : 40

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Author: Alain R. Puente-Santiago
Publisher: Springer Nature
ISBN: 303055502X
Category : Science
Languages : en
Pages : 255

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Book Description
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Author: Zhifei Dai
Publisher: Springer
ISBN: 9811000638
Category : Technology & Engineering
Languages : en
Pages : 386

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Book Description
This book surveys recent advances in theranostics based on magnetic nanoparticles, ultrasound contrast agents, silica nanoparticles and polymeric micelles. It presents magnetic nanoparticles, which offer a robust tool for contrast enhanced MRI imaging, magnetic targeting, controlled drug delivery, molecular imaging guided gene therapy, magnetic hyperthermia, and controlling cell fate. Multifunctional ultrasound contrast agents have great potential in ultrasound molecular imaging, multimodal imaging, drug/gene delivery, and integrated diagnostics and therapeutics. Due to their diversity and multifunctionality, polymeric micelles and silica-based nanocomposites are highly capable of enhancing the efficacy of multimodal imaging and synergistic cancer therapy. This comprehensive book summarizes the main advances in multifunctional nanoprobes for targeted imaging and therapy of gastric cancer, and explores the clinical translational prospects and challenges. Although more research is needed to overcome the substantial obstacles that impede the development and availability of nanotheranostic products, such nontrivial nanoagents are expected to revolutionize medical treatments and help to realize the potential of personalized medicine to diagnose, treat, and follow-up patients with cancer. Zhifei Dai is a Professor at the Department of Biomedical Engineering, College of Engineering, Peking University, China.

Author: Jeff W.M. Bulte
Publisher: Springer
ISBN: 3319421697
Category : Medical
Languages : en
Pages : 467

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Book Description
This book covers the most recent advances in using nanoparticles for biomedical imaging, including magnetic resonance imaging (MRI), magnetic particle imaging (MPI), nuclear medicine, ultrasound (US) imaging, computed tomography (CT), and optical imaging. Topics include nanoparticles for MRI and MPI, siRNA delivery, theranostic nanoparticles for PET imaging of drug delivery, US nanoparticles for imaging drug delivery, inorganic nanoparticles for targeted CT imaging, and quantum dots for optical imaging. This book serves as a valuable resource for the fundamental science of diagnostic nanoparticles and their interactions with biological targets, providing a practical handbook for improved detection of disease and its clinical implementation.

Author: Gaio Paradossi
Publisher: Springer Science & Business Media
ISBN: 8847014948
Category : Technology & Engineering
Languages : en
Pages : 199

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Book Description
Recent advancements in nano/micro materials and related characterization approaches allow the design of a new type of ultrasound contrast agents (UCAs) with enhanced multifunctional behaviour. This is chance is also supported by the recent achievements in modelling and signal processing. This book provides the state of art of the research activity of two successful European projects, TAMIRUT and SIGHT, addressing an integrated system, encompassing the contrast agent, the hardware equipment and the processing strategies, as a key tool for a combined diagnostic and therapeutic approaches (theranostics) in medical ultrasound. The work provides a highlight of the state of art in the research of novel ultrasound contrast agents (UCAs). Main progresses on the multifunctional aspects of next-generation UCAs concern targeting and drug release properties, perfusion and biointerface behaviour, ultrasound scattering performance, signal processing, electronic equipment.

Author: Bashar Issa
Publisher:
ISBN:
Category : Electronic books
Languages : en
Pages : 0

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Magnetic Resonance Imaging (MRI) is a non-invasive imaging modality that offers both anatomical and functional information. Intrinsic longitudinal and transverse relaxation times (T1 and T2, respectively) provide tools to manipulate image contrast. Additional control is yielded when paramagnetic and magnetic particulate materials are used as contrast materials. Superparamagnetic particles are mostly synthesized from iron oxide and are usually coated with polymers and functional particles to offer multifunctional biomedical applications. The latter include not only MRI but also cancer treatment through drug delivery and hyperthermia. This Chapter reviews the fundamental dipole,Äìdipole diamagnetic proton relaxation mechanism dominant in water followed by a brief description of the use of gadolinium complexes as MRI contrast agent. Finally, a description of the important chemical and physical properties of magnetic nanoparticle (MNP) that define their use as MRI relaxation enhancing agents especially for T2. The main governing models are described for the different motional regimes with few simulation results demonstrating the applicability of the given equations.

Author: Sophie Laurent
Publisher: Springer
ISBN: 9811025290
Category : Technology & Engineering
Languages : en
Pages : 128

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This book describes the multiple aspects of (i) preparation of the magnetic core, (ii) the stabilization with different coatings, (iii) the physico-chemical characterization and (iv) the vectorization to obtain specific nanosystems. Several bio-applications are also presented in this book. In the early days of Magnetic Resonance Imaging (MRI), paramagnetic ions were proposed as contrast agents to enhance the diagnostic quality of MR images. Since then, academic and industrial efforts have been devoted to the development of new and more efficient molecular, supramolecular and nanoparticular systems. Old concepts and theories, like paramagnetic relaxation, were revisited and exploited, leading to new scientific tracks. With their high relaxivity payload, the superparamagnetic nanoparticles are very appealing in the context of molecular imaging but challenges are still numerous: absence of toxicity, specificity, ability to cross the biological barriers, etc.

Author: Jeff W.M. Bulte
Publisher: Springer Science & Business Media
ISBN: 0387720278
Category : Medical
Languages : en
Pages : 521

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Book Description
The current generation of imaging nanoparticles is diverse and dependent on its myriad of applications. This book provides an overview of how these imaging particles can be designed to fulfill specific requirements for applications across different imaging modalities. It presents, for the first time, a comprehensive interdisciplinary overview of the impact nanoparticles have on biomedical imaging and is a common central resource for researchers and teachers.

Author: Nguyen TK Thanh
Publisher: CRC Press
ISBN: 1439869324
Category : Science
Languages : en
Pages : 613

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Book Description
Offering the latest information in magnetic nanoparticle (MNP) research, Magnetic Nanoparticles: From Fabrication to Clinical Applications provides a comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. This book, written by some of the most qualified experts in the field, not only fills a hole in the literature, but also bridges the gaps between all the different areas in this field. Translational research on tailored magnetic nanoparticles for biomedical applications spans a variety of disciplines, and putting together the most significant advances into a practical format is a challenging task. Balancing clinical applications with the underlying theory and foundational science behind these new discoveries, Magnetic Nanoparticles: From Fabrication to Clinical Applications supplies a toolbox of solutions and ideas for scientists in the field and for young researchers interested in magnetic nanoparticles.

Author: Andre S. Merbach
Publisher: John Wiley & Sons
ISBN: 1118503678
Category : Science
Languages : en
Pages : 514

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Book Description
Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement. This completely revised and extended second edition: Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents. Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations. Is written for all of those involved in the development and application of contrast agents in MRI. Presented in colour, it provides readers with true representation and easy interpretation of the images. A word from the Authors: Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms. Reviews of the First Edition: "...attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique..."—Journal of the American Chemical Society "...well balanced in its scope and attention to detail...a valuable addition to the library of MR scientists..."—NMR in Biomedicine