Author: Yi Rao Publisher: World Scientific ISBN: 9813109912 Category : Medical Languages : en Pages : 223
Book Description
Nobel laureate Tu Youyou won the 2015 prize for Medicine/Physiology for the discovery of artemisinin, a drug therapy for malaria that has saved millions across the globe.This book traces the path of discovery beginning with Chairman Mao's 1964 instruction to Chinese researchers to find a cure for malaria, a disease that plagued the military and civilians alike in endemic regions. It chronicles the years of painstaking research to find effective anti-malarial drugs, and how an entry in a collection of traditional Chinese medicine prescriptions gave Tu Youyou the clue which led her to successfully extract artemisinin from the plant, Artemisia annua.Gathering together information from a variety of sources including first-hand accounts, this book describes the contributions of the many organisations, scientists, doctors and countless others who played a part in the process of discovery and clinical testing. It also provides insights into the challenges of carrying out such an extensive research project with limited resources during the upheavals of the Cultural Revolution. An inspirational read for young scientists.Includes the translation of Professor Tu Youyou's 2015 Nobel Lecture.
Author: Wenhu Zhang Publisher: World Scientific ISBN: 9813207663 Category : Medical Languages : en Pages : 131
Book Description
Tu Youyou's Journey in the Search for Artemisinin is an autobiographical science book chronicling in detail the great experiences of Tu Youyou from her childhood to winning the Nobel Prize in Physiology or Medicine.As Tu Youyou is the first female scientist from China to win the Nobel Prize in Physiology or Medicine, this win created a sudden wave of interest in medicine, resulting in numerous autobiographical books about Tu Youyou appearing on the market. Contrary to these mass market titles, this book is uniquely different as it is fully authorized by the Nobel laureate herself. Her once-confidential experimental data and Artemisinin research reports are now revealed in this book for all to learn and comprehend. In addition, one of the book authors, Dr Wang Manyuan, is the only PhD student supervised by Professor Tu.Pharmaceutical researchers can use the book's valuable contents to reference, quote and analyse while searching for their own scientific inspirations. It also successfully serves as a guide for budding scientists and future Nobel Prize winners as it provides the proper guidance and methods of scientific research.
Author: World Health Organization Publisher: World Health Organization ISBN: 9241549122 Category : Medical Languages : en Pages : 317
Book Description
Malaria remains an important cause of illness and death in children and adults in countries in which it is endemic. Malaria control requires an integrated approach including prevention (primarily vector control) and prompt treatment with effective antimalarial agents. Malaria case management consisting of prompt diagnosis and effective treatment remains a vital component of malaria control and elimination strategies. Since the publication of the first edition of the Guidelines for the treatment of malaria in 2006 and the second edition in 2010 all countries in which P. falciparum malaria is endemic have progressively updated their treatment policy from use of ineffective monotherapy to the currently recommended artemisinin-based combination therapies (ACT). This has contributed substantially to current reductions in global morbidity and mortality from malaria. Unfortunately resistance to artemisinins has arisen recently in P. falciparum in South-East Asia which threatens these gains. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on a firmer evidence base for most antimalarial drugs and in addition include recommendation on the use of drugs to prevent malaria in groups at high risk. The Guidelines provide a framework for designing specific detailed national treatment protocols taking into account local patterns of resistance to antimalarial drugs and health service capacity. It provides recommendations on treatment of uncomplicated and severe malaria in all age groups all endemic areas in special populations and several complex situations. In addition on the use of antimalarial drugs as preventive therapy in healthy people living in malaria-endemic areas who are high risk in order to reduce morbidity and mortality from malaria. The Guidelines are designed primarily for policy-makers in ministries of health who formulate country-specific treatment guidelines. Other groups that may find them useful include health professionals and public health and policy specialists that are partners in health or malaria control and the pharmaceutical industry. The treatment recommendations in the main document are brief; for those who wish to study the evidence base in more detail a series of annexes is provided with references to the appropriate sections of the main document.
Author: Songju Ma Daemicke Publisher: Albert Whitman & Company ISBN: 0807581100 Category : Juvenile Nonfiction Languages : en Pages : 36
Book Description
2024 Garden State Children's Book Award Nominee 2023 Finalist AAAS/Subaru SB&F Prize for Excellence in Science Books Tu Youyou's malaria treatment saved millions of lives, and she became the first Chinese woman to win a Nobel Prize. Tu Youyou had been interested in science and medicine since she was a child, so when malaria started infecting people all over the world in 1969, she went to work finding a treatment. Trained as a medical researcher in college and healed by traditional medicine techniques when she was young, Tu Youyou started experimenting with natural Chinese remedies. The treatment she discovered through years of research and experimentation is still used all over the world today.
Author: Tariq Aftab Publisher: Springer Science & Business Media ISBN: 3642410278 Category : Science Languages : en Pages : 288
Book Description
Artemisinin, a sesquiterpene lactone originally extracted from the medicinal plant Artemisia annua L., is an effective antimalarial agent, particularly for multi-drug resistant and cerebral malaria. However, the concentration of artemisinin in the plant is very low. Because the chemical synthesis of artemisinin is complicated and not economically feasible in view of the poor yield of the drug, the intact plant remains the only viable source of artemisinin production. Therefore, it is necessary to increase the concentration of artemisinin in A. annua to reduce the cost of artemisinin based antimalarial drugs. Plant scientists have focused their efforts on A. annua for a higher artemisinin crop yield. With the present volume, we are bringing together the research which is being done on this plant throughout the world and future possibilities for scientists and researchers who want to work on it.
Author: Beverley Isherwood Publisher: Royal Society of Chemistry ISBN: 1839160799 Category : Medical Languages : en Pages : 273
Book Description
Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.
Author: World Health Organization Publisher: World Health Organization ISBN: 9241564830 Category : Medical Languages : en Pages : 241
Book Description
The World malaria report 2014 summarizes information received from 97 malaria endemic countries and other sources and updates the analyses presented in 2013. It assesses global and regional malaria trends highlights progress made towards global targets and describes opportunities and challenges in controlling and eliminating the disease. Most of the data presented in this report are for 2013.
Author: Guan-Hua Du Publisher: Springer ISBN: 9811080224 Category : Medical Languages : en Pages : 741
Book Description
This book discusses 120 types of natural, small-molecule drugs derived from plants. They are grouped into 7 parts according their clinical uses, such as drugs for cardiovascular diseases, for metabolic diseases, for neuropsychiatric diseases, for immune-mediated inflammatory diseases, anti-tumor drugs, and drugs for parasites and bacterial infection. Each chapter systematically summarizes one drug, including its physicochemical properties, sources, pharmacological effects and clinical applications. To help readers understand the drug better, the research and pharmacological activity for each drug is also described, which serves as a salutary lesson for future drug development. Written by frontline researchers, teachers and clinicians working in field of pharmacy and pharmacology it provides an overview of natural, small-molecule drugs derived from plants for researchers in the field.