Transcriptome Organization in Human and Chimpanzee Brains PDF Download

Author: Michael Clark Oldham
Publisher:
ISBN:
Category :
Languages : en
Pages : 704

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Author:
Publisher: Academic Press
ISBN: 0128013192
Category : Science
Languages : en
Pages : 365

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Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume, concentrates on the brain transcriptome. Brings together cutting-edge research on the brain transcriptome

Author: Kenichi Oishi
Publisher: Academic Press
ISBN: 0123820820
Category : Science
Languages : en
Pages : 266

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MRI Atlas of Human White Matter presents an atlas to the human brain on the basis of T 1-weighted imaging and diffusion tensor imaging. A general background on magnetic resonance imaging is provided, as well as the basics of diffusion tensor imaging. An overview of the principles and limitations in using this methodology in fiber tracking is included. This book describes the core white-matter structures, as well as the superficial white matter, the deep gray matter, and the cortex. It also presents a three-dimensional reconstruction and atlas of the brain white-matter tracts. The Montreal Neurological Institute coordinates, which are the most widely used, are adopted in this book as the primary coordinate system. The Talairach coordinate system is used as the secondary coordinate system. Based on magnetic resonance imaging and diffusion tensor imaging, the book offers a full segmentation of 220 white-matter and gray-matter structures with boundaries. Visualization of brain white matter anatomy via 3D diffusion tensor imaging (DTI) contrasts and enhances relationship of anatomy to function Full segmentation of 170+ brain regions more clearly defines structure boundaries than previous point-and-annotate anatomical labeling, and connectivity is mapped in a way not provided by traditional atlases

Author: Ann Arvin
Publisher: Cambridge University Press
ISBN: 1139461648
Category : Medical
Languages : en
Pages : 1325

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This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Author: Tomas Paus
Publisher: Springer Science & Business Media
ISBN: 3642364500
Category : Medical
Languages : en
Pages : 198

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Is Newton’s brain different from Rembrandt’s? Does a mother’s diet during pregnancy impact brain growth? Do adolescent peers leave a signature in the social brain? Does the way we live in our middle years affect how our brains age? To answer these and many other questions, we can now turn to population neuroscience. Population neuroscience endeavors to identify environmental and genetic factors that shape the function and structure of the human brain; it uses the tools and knowledge of genetics (and the “omics” sciences), epidemiology and neuroscience. This text attempts to provide a bridge spanning these three disciplines so that their practitioners can communicate easily with each other when working together on large-scale imaging studies of the developing, mature and aging brain. By understanding the processes driving variations in brain function and structure across individuals, we will also be able to predict an individual’s risk of (or resilience against) developing a brain disorder. In the long term, the hope is that population neuroscience will lay the foundation for personalized preventive medicine and, in turn, reduce the burden associated with complex, chronic disorders of brain and body.

Author: George Paxinos
Publisher: Academic Press
ISBN: 0128158530
Category : Medical
Languages : en
Pages : 394

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Paxinos and Petrides' The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive and accurate atlas of the monkey brain currently available. The fourth edition of this classic book will be a complete revision, featuring many improvements and upgrades. Containing coronal diagrams and accompanying photographic plates spaced at 120 μm intervals, this atlas follows the same nomenclature and abbreviations conventions as the mouse, rat, chicken, and human brain atlases published under George Paxinos’ leadership. This atlas is suitable for researchers who work with both monkeys and humans. Constructed by the established leaders in neuroanatomical atlas development, the new edition will again be the indispensable resource for all scientists working on the primate nervous system. 141 completely revised coronal diagrams and accompanying colour photographic plates spaced at approximately 120 μm intervals 60 colour photographic coronal plates of SMI immunoreactivity with completely revised delineations Includes MR images at approximately the same levels as the coronal diagrams Follows the same nomenclature and abbreviations as the mouse, rat, chicken, marmoset and human brain atlases, with indications of correspondence to alternative macaque nomenclatures This atlas was used for the delineation and nomenclature of MRI-based macaque brain atlases for neuroimaging analyses, including the SARM

Author: Suzana Herculano-Houzel
Publisher: MIT Press
ISBN: 0262333201
Category : Science
Languages : en
Pages : 271

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Why our human brains are awesome, and how we left our cousins, the great apes, behind: a tale of neurons and calories, and cooking. Humans are awesome. Our brains are gigantic, seven times larger than they should be for the size of our bodies. The human brain uses 25% of all the energy the body requires each day. And it became enormous in a very short amount of time in evolution, allowing us to leave our cousins, the great apes, behind. So the human brain is special, right? Wrong, according to Suzana Herculano-Houzel. Humans have developed cognitive abilities that outstrip those of all other animals, but not because we are evolutionary outliers. The human brain was not singled out to become amazing in its own exclusive way, and it never stopped being a primate brain. If we are not an exception to the rules of evolution, then what is the source of the human advantage? Herculano-Houzel shows that it is not the size of our brain that matters but the fact that we have more neurons in the cerebral cortex than any other animal, thanks to our ancestors' invention, some 1.5 million years ago, of a more efficient way to obtain calories: cooking. Because we are primates, ingesting more calories in less time made possible the rapid acquisition of a huge number of neurons in the still fairly small cerebral cortex—the part of the brain responsible for finding patterns, reasoning, developing technology, and passing it on through culture. Herculano-Houzel shows us how she came to these conclusions—making “brain soup” to determine the number of neurons in the brain, for example, and bringing animal brains in a suitcase through customs. The Human Advantage is an engaging and original look at how we became remarkable without ever being special.

Author: Shawn M. Lehman
Publisher: Springer Science & Business Media
ISBN: 0387298711
Category : Science
Languages : en
Pages : 552

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Primate Biogeography is a subject rarely addressed as a discipline in its own right. This comprehensive source introduces the reader to Primate Biogeography as a discipline. It highlights the many factors that may influence the distribution of primates, and reveals the wide range of approaches that are available to understanding the distribution of this order. The biogeography of primates in the past is a major component of our understanding of their evolutionary history and is an essential component of conservation biology. This book will appeal to primatologists, physical anthropologists, zoologists, and undergraduates in these areas.

Author: Alessandro Cellerino
Publisher: Springer
ISBN: 8876426426
Category : Mathematics
Languages : en
Pages : 196

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The goal of this book is to be an accessible guide for undergraduate and graduate students to the new field of data-driven biology. Next-generation sequencing technologies have put genome-scale analysis of gene expression into the standard toolbox of experimental biologists. Yet, biological interpretation of high-dimensional data is made difficult by the lack of a common language between experimental and data scientists. By combining theory with practical examples of how specific tools were used to obtain novel insights in biology, particularly in the neurosciences, the book intends to teach students how to design, analyse, and extract biological knowledge from transcriptome sequencing experiments. Undergraduate and graduate students in biomedical and quantitative sciences will benefit from this text as well as academics untrained in the subject.

Author: Douglas C. Broadfield
Publisher:
ISBN: 9780979227639
Category : Brain
Languages : en
Pages : 0

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The Human Brain Evolving: Paleoneurological Studies in Honor of Ralph L. Holloway presents a range of important studies focusing on human brain evolution. Based upon a Stone Age Institute conference held at Indiana University, Bloomington, this book features many of the principal investigators in palaeoneurology and related fields. Topics include theoretical concepts, studies of fossil and modern brain endocasts, genetic studies, neurological structure and development and brain evolution and its relation to behaviour. This state-of-the-art collection of papers expands our knowledge and understanding of human brain evolution, highlights current issues in the field and suggests new avenues of inquiry for the future.