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Author: Benedict C. Albensi Publisher: ISBN: 9781608054183 Category : Science Languages : en Pages : 144
Book Description
The main theme of this book is to critically survey the role of two recognized protein molecules (i.e., transcription factors) in processes of human memory. In addition, authors provided recent data from their own labs and provided a perspective relevant to specific neurological diseases and potential drug targets. Historically, the transcription factor cAMP response element-binding (CREB) has been the most well documented transcription factor shown to play a role in memory. CREB has several functions, but its most notable function has to do with the formation of long-term memories. More recently, other transcription factors, such as C/EBP, Egr protein, AP-1, and NF-κB have been implicated in memory as well. Of these, scientific literature on NF-κB's theorized role in synaptic plasticity and memory is growing rapidly. Interestingly, in some recent studies CREB and NF-κB have also been shown to interact with each other where both contribute in a cooperative fashion to the initiation of gene expression.
Author: Benedict C. Albensi Publisher: ISBN: 9781608054183 Category : Science Languages : en Pages : 144
Book Description
The main theme of this book is to critically survey the role of two recognized protein molecules (i.e., transcription factors) in processes of human memory. In addition, authors provided recent data from their own labs and provided a perspective relevant to specific neurological diseases and potential drug targets. Historically, the transcription factor cAMP response element-binding (CREB) has been the most well documented transcription factor shown to play a role in memory. CREB has several functions, but its most notable function has to do with the formation of long-term memories. More recently, other transcription factors, such as C/EBP, Egr protein, AP-1, and NF-κB have been implicated in memory as well. Of these, scientific literature on NF-κB's theorized role in synaptic plasticity and memory is growing rapidly. Interestingly, in some recent studies CREB and NF-κB have also been shown to interact with each other where both contribute in a cooperative fashion to the initiation of gene expression.
Author: Benedict C. Albensi Publisher: Bentham Science Publishers ISBN: 1608052575 Category : Science Languages : en Pages : 141
Book Description
The main theme of this book is to critically survey the role of two recognized protein molecules (i.e., transcription factors) in processes of human memory. In addition, authors provided recent data from their own labs and provided a perspective relevant to specific neurological diseases and potential drug targets. Historically, the transcription factor cAMP response element-binding (CREB) has been the most well documented transcription factor shown to play a role in memory. CREB has several functions, but its most notable function has to do with the formation of long-term memories. More recen.
Author: Sankar Ghosh Publisher: CRC Press ISBN: 1420004271 Category : Medical Languages : en Pages : 246
Book Description
Recent evidence proving the molecular link between unchecked, chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response, NF-kB is prov
Author: Gerald Thiel Publisher: John Wiley & Sons ISBN: 3527607366 Category : Science Languages : en Pages : 505
Book Description
This first book to cover neural development, neuronal survival and function on the genetic level outlines promising approaches for novel therapeutic strategies in fighting neurodegenerative disorders, such as Alzheimer's disease. Focusing on transcription factors, the text is clearly divided into three sections devoted to transcriptional control of neural development, brain function and transcriptional dysregulation induced neurological diseases. With a chapter written by Nobel laureate Eric Kandel, this is essential reading for neurobiologists, geneticists, biochemists, cell biologists, neurochemists and molecular biologists.
Author: Hsiou-Chi Liou Publisher: Springer Science & Business Media ISBN: 0387335730 Category : Science Languages : en Pages : 202
Book Description
Since its first discovery in the early 90’s, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-kB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-kB/Rel transcription factor family.
Author: Juliusz Ashot Kozak Publisher: CRC Press ISBN: 149875273X Category : Science Languages : en Pages : 343
Book Description
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Author: Gabriel Lopez-Berestein Publisher: CRC Press ISBN: 9780849347061 Category : Medical Languages : en Pages : 264
Book Description
Mononuclear Phagocytes in Cell Biology provides a state-of-the-art review of the biological, biochemical, and molecular processes involved in macrophage activation. The book focuses on the role of macrophage "signals" in health and disease, which are discussed with particular attention to the physiological role of macrophages in homeostasis. The role played by macrophages in bone metabolism and the role of cytokines in diseases affecting the macrophage (e.g., HIV and leishmaniasis) are covered as well. The book also exploits the potential of macrophage "mimicry" as a therapeutic tool. Mononuclear Phagocytes in Cell Biology is a practical reference for cell biologists, medical microbiologists, molecular biologists, immunologists, hematologists, immunogeneticists, immunopharmacologists, and other basic and clinical researchers interested in macrophage development, biology, and differentiation.
Author: Benedict C. Albensi
Author: Benedict C. Albensi
Author: Benedict C. Albensi
Author: Benedict C. Albensi
Author: Sankar Ghosh
Author: Gerald Thiel
Author: Hsiou-Chi Liou
Author: Payam Samareh Pahlavan
Author: Juliusz Ashot Kozak
Author: Athanasios Papavassiliou
Author: Gabriel Lopez-Berestein