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Undergraduate Training in Mammary Gland Biology and Breast Cancer

Undergraduate Training in Mammary Gland Biology and Breast Cancer PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 45

Book Description
This research report describes the third and final year of the BCRT undergraduate research training program in breast cancer. The goal of this project was to provide undergraduate trainees with exposure to areas of breast cancer research that focus on the role of microenvironment in mammary gland biology and in the development of neoplasia. Trainees in this project benefited from working in a program that investigates the intersection of hormones, growth factors, and extracellular matrix (ECM) signaling and remodeling during mammary gland morphogenesis, differentiation, and carcinogenesis. The program was advertised through several undergraduate research forums on the UC Berkeley campus, and more than forty applications were received. From these, eight applicants were selected to represent a balance of interests and approaches, with broad levels of expertise ranging from laboratory novices to students with many years of laboratory experience. During the research portion of the program, undergraduate trainees had frequent interaction with mentors and with advanced postdoctoral fellows, and reports were presented in organized, biweekly meetings structured to reflect the organization of a research paper. At the first meeting, the students presented the introduction to their research project; at the second, the materials and methods; at the third, the results. For the final meeting of the program, the students presented their work in complete form, including conclusions and interpretations. While the success at obtaining experimental results within the allotted time of the research program varies, all the participants (both students and preceptors) agreed that the overall experience was successful.

Undergraduate Training in Mammary Gland Biology and Breast Cancer

Undergraduate Training in Mammary Gland Biology and Breast Cancer PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 45

Book Description
This research report describes the third and final year of the BCRT undergraduate research training program in breast cancer. The goal of this project was to provide undergraduate trainees with exposure to areas of breast cancer research that focus on the role of microenvironment in mammary gland biology and in the development of neoplasia. Trainees in this project benefited from working in a program that investigates the intersection of hormones, growth factors, and extracellular matrix (ECM) signaling and remodeling during mammary gland morphogenesis, differentiation, and carcinogenesis. The program was advertised through several undergraduate research forums on the UC Berkeley campus, and more than forty applications were received. From these, eight applicants were selected to represent a balance of interests and approaches, with broad levels of expertise ranging from laboratory novices to students with many years of laboratory experience. During the research portion of the program, undergraduate trainees had frequent interaction with mentors and with advanced postdoctoral fellows, and reports were presented in organized, biweekly meetings structured to reflect the organization of a research paper. At the first meeting, the students presented the introduction to their research project; at the second, the materials and methods; at the third, the results. For the final meeting of the program, the students presented their work in complete form, including conclusions and interpretations. While the success at obtaining experimental results within the allotted time of the research program varies, all the participants (both students and preceptors) agreed that the overall experience was successful.

Training in Mammary Gland Biology and Breast Cancer

Training in Mammary Gland Biology and Breast Cancer PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 19

Book Description
The goal of the present proposal is to provide post-doctoral training opportunities in breast cancer research that focus on the role of microenvironmental in mammary gland biology. Trainees will benefit from working in a dynamic interactive program under the guidance of the LBNL mentors to investigate the intersection of hormone action, growth factor activity, and extracellular matrix remodeling during mammary gland development and carcinogenesis. In addition, trainees will be exposed to a variety of other topics related to breast cancer, as well as research ranging from molecular medicine to genomics, by their participation in working groups, lectures and scientific meetings with other Berkeley Lab and Bay Area researchers.

Methods in Mammary Gland Biology and Breast Cancer Research

Methods in Mammary Gland Biology and Breast Cancer Research PDF Author: Margot M. Ip
Publisher: Springer Science & Business Media
ISBN: 1461542952
Category : Medical
Languages : en
Pages : 350

Book Description
approaches to the experimental problems that still face us in understanding this most fascinating of organs. Too many people contributed to the completion of this volume to allow acknowledg ment of all the individual efforts, but we particularly thank the reviewers whose input into the editorial process was invaluable and the authors of these chapters who revised their text, sometimes more than once, to bring it to the high standards set by the Editors. The Com mittee gratefully acknowledges the support ofVysis, Inc. , in the publication of a color figure in Chapter 19, by S. Weber-Hall and Trevor Dale. Finally, we wish to express our heartfelt appreciation to Margot Ip and Bonnie Asch, who worked long and hard to bring this volume to fruition. Margaret C. Neville for the Committee on Mammary Gland Biology Preface One of the most exciting and beneficial developments in research on mammary gland biology and breast cancer has been the influx of increased funding to support this work. This influx, which has been due primarily to the tireless efforts of breast cancer activists to gamer addi tional money from various federal and state sources, has led to a rapid expansion of research efforts by attracting numerous new investigators into the field. These new investigators include students, postdoctoral fellows, and scientists from other fields.

Breast Cancer and the Environment

Breast Cancer and the Environment PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309220696
Category : Medical
Languages : en
Pages : 468

Book Description
Breast cancer remains the most common invasive cancer among women. The primary patients of breast cancer are adult women who are approaching or have reached menopause; 90 percent of new cases in U.S. women in 2009 were diagnosed at age 45 or older. Growing knowledge of the complexity of breast cancer stimulated a transition in breast cancer research toward elucidating how external factors may influence the etiology of breast cancer. Breast Cancer and the Environment reviews the current evidence on a selection of environmental risk factors for breast cancer, considers gene-environment interactions in breast cancer, and explores evidence-based actions that might reduce the risk of breast cancer. The book also recommends further integrative research into the elements of the biology of breast development and carcinogenesis, including the influence of exposure to a variety of environmental factors during potential windows of susceptibility during the full life course, potential interventions to reduce risk, and better tools for assessing the carcinogenicity of environmental factors. For a limited set of risk factors, evidence suggests that action can be taken in ways that may reduce risk for breast cancer for many women: avoiding unnecessary medical radiation throughout life, avoiding the use of some forms of postmenopausal hormone therapy, avoiding smoking, limiting alcohol consumption, increasing physical activity, and minimizing weight gain. Breast Cancer and the Environment sets a direction and a focus for future research efforts. The book will be of special interest to medical researchers, patient advocacy groups, and public health professionals.

Perspectives in Mammary Gland Development and Breast Cancer Research

Perspectives in Mammary Gland Development and Breast Cancer Research PDF Author: Zuzana Koledova
Publisher: Frontiers Media SA
ISBN: 288966094X
Category : Science
Languages : en
Pages : 158

Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Charting the Course

Charting the Course PDF Author: National Cancer Institute (U.S.). Breast Cancer Progress Review Group
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 152

Book Description


Cellular and Molecular Biology of Mammary Cancer

Cellular and Molecular Biology of Mammary Cancer PDF Author: E. Anderson
Publisher: Springer Science & Business Media
ISBN: 1461309433
Category : Science
Languages : en
Pages : 519

Book Description
The idea for this book arose during the 1985 Gordon Conference on "Mammary Gland Biology". New developments in the methodology of cell biology and the explosive growth of molecular biology had begun to impact upon our understanding of mammary gland growth and function. It seemed a propitious time for summarizing the current status of knowledge of the cell and molecular biology of mammary cancer and for attempting to outline future areas of concern and interest. The reviews presented here were completed by the Fall of 1986. Although new insights will surely continue to emerge, it is hoped that the material in this volume will form not only a current update but a basic core of information for future experiments. We have not attempted to cover all areas of mammary gland transformation. Those areas where recent detailed reviews are already available have been omitted. Also, the areas of normal gland development, cell ultrastructure, hormone responsiveness, chemotherapy and clinical aspects of mammary cancer have not been included. Instead, we have selected those areas where the development of new methodology, reagents and results have led to new ideas about mammary gland function and development as they are related to neoplasia.

Breast Cancer Biology

Breast Cancer Biology PDF Author: Dil Afroze
Publisher: BoD – Books on Demand
ISBN: 1789239613
Category : Medical
Languages : en
Pages : 127

Book Description
This book offers a comprehensive overview of recent developments in the field of breast cancer biology. It is a complete and descriptive reference on motioning pathways and new treatment options for the future transnational scientists and clinicians working on cancer research and treatment. We greatly appreciate the work of all the contributors to this book. They have brought with them tremendous diversity of perspectives and fields, which is truly reflective of the complexity of the topic, and they have come together in this project to serve as the node of multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies, and who have inspired us to gather information to significantly progress knowledge in the field in recent years.

Mammary gland biology and breast cancer

Mammary gland biology and breast cancer PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 901

Book Description


Regulatory Mechanisms in Breast Cancer

Regulatory Mechanisms in Breast Cancer PDF Author: Marc E. Lippman
Publisher: Springer Science & Business Media
ISBN: 1461539404
Category : Medical
Languages : en
Pages : 455

Book Description
In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.