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Author: H. Thomas Publisher: CRC Press ISBN: 074840239X Category : Science Languages : en Pages : 395
Book Description
A large number of chemical compunds are constantly being introduced and produced, both to assist and ease modern human life. Among these chemicals, industrial compounds represent a particular fraction of chemicals which are not intended for use in biological systems, but to which humans may be accidently exposed, whether in the workplace, by product application, or via the environment. Industrial chemicals, as opposed to pharmaceuticals and agrochemicals, are in many cases subjected only to a very basic examination of handling safety, and may lack further toxicity testing. This implies that essentially nothing is known about their bioavailability, metabolism, excretion and toxicological properties, unless problems arise.; Covering the investigation of industrial chemicals, this book focuses on their individual structure, biological fate, potential toxicity to mammals and the molecular mechanisms possibly underlying their adverse effects by highlighting the use and significance of experimental toxicology. Special emphasis is placed on mechanistic aspects in the safety assessment of industrial compounds, in addition to current regulatory and legal considerations.
Author: H. Thomas Publisher: CRC Press ISBN: 074840239X Category : Science Languages : en Pages : 395
Book Description
A large number of chemical compunds are constantly being introduced and produced, both to assist and ease modern human life. Among these chemicals, industrial compounds represent a particular fraction of chemicals which are not intended for use in biological systems, but to which humans may be accidently exposed, whether in the workplace, by product application, or via the environment. Industrial chemicals, as opposed to pharmaceuticals and agrochemicals, are in many cases subjected only to a very basic examination of handling safety, and may lack further toxicity testing. This implies that essentially nothing is known about their bioavailability, metabolism, excretion and toxicological properties, unless problems arise.; Covering the investigation of industrial chemicals, this book focuses on their individual structure, biological fate, potential toxicity to mammals and the molecular mechanisms possibly underlying their adverse effects by highlighting the use and significance of experimental toxicology. Special emphasis is placed on mechanistic aspects in the safety assessment of industrial compounds, in addition to current regulatory and legal considerations.
Author: Raymond D. Harbison Publisher: John Wiley & Sons ISBN: 0470929731 Category : Science Languages : en Pages : 1364
Book Description
Providing a concise, yet comprehensive, reference on all aspects of industrial exposures and toxicants; this book aids toxicologists, industrial hygienists, and occupational physicians to investigate workplace health problems. • Updates and expands coverage with new chapters covering regulatory toxicology, toxicity testing, physical hazards, high production volume (HPV) chemicals, and workplace drug use • Includes information on occupational and environmental sources of exposure, mammalian toxicology, industrial hygiene, medical management and ecotoxicology • Retains a succinct chapter format that has become the hallmark for the previous editions • Distils a vast amount of information into one resource for both academics and professionals
Author: K.L. Kaiser Publisher: Springer Science & Business Media ISBN: 9789027725554 Category : Science Languages : en Pages : 498
Book Description
Over the past few years, research in the field of quantitative structure-activity relationships (QSAR) in chemistry, biology, pharmacology, toxicology, and environmental sciences has seen strong growth. New journals and books have appeared in each of these fields, however, the combination of QSAR and environmental sciences is still in its infancy. After the success of the Workshop on Quantitative Structure-Activity Relationships (QSAR) in Environmental Toxicology, held at McMaster University, Aug ust 16-18, 1983, with the proceedings publ ished in 1984 [QSA R in Environmental Toxicology, Kaiser, K. L. E. (Ed. ), D. Reidel Pub!. Co. , Dordrecht, 406 p. , ISBN 90-277 -1776-1], it was time to hold another workshop in 1986. Indeed, the response by the scientific community was excellent with over 50 participants from Canada, Germany, Great Britain, Hungary, India, Japan, The Netherlands, United States, and Yugoslavia. Moreover, both breadth and depth of papers given were significantly improved and the workshop discussions were intense and frank. Regrettably, the number of participants, number of papers given and submitted for these proceedings made it impossible to include the workshop discussions of these papers. However, several manuscripts were revised on the basis of these discussions and, therefore, do reflect this very interactive workshop. This volume presents the majority of papers given at the 2nd International Workshop on QSAR in Environmental Toxicology, held at McMaster University, June 9-13, 1986. Many of these papers contain primary, new scientific data, equations and results which will not appear elsewhere.
Author: Ramesh C Gupta Publisher: Academic Press ISBN: 0080543103 Category : Technology & Engineering Languages : en Pages : 781
Book Description
This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs. In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides. - Describes everything you need to know about Organophosphates and Carbamates - Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants - Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates - Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases - Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity - Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis - Provides in vitro and in vivo models for neurotoxicity testing - Integrates knowledge of studies in lab animals and humans - Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues - Describes management of Anticholinesterase poisoning in humans
Author: United States. Public Health Service. Office of the Surgeon General Publisher: ISBN: Category : Government publications Languages : en Pages : 728
Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: Pradyot Patnaik Publisher: John Wiley & Sons ISBN: 0470134941 Category : Technology & Engineering Languages : en Pages : 1086
Book Description
The definitive guide to the hazardous properties of chemical compounds Correlating chemical structure with toxicity to humans and the environment, and the chemical structure of compounds to their hazardous properties, A Comprehensive Guide to the Hazardous Properties of Chemical Substances, Third Edition allows users to assess the toxicity of a substance even when no experimental data exists. Thus, it bridges the gap between hazardous materials and chemistry. Extensively updated and expanded, this reference: Examines organics, metals and inorganics, industrial solvents, common gases, particulates, explosives, and radioactive substances, covering everything from toxicity and carcinogenicity to flammability and explosive reactivity to handling and disposal practices Arranges hazardous chemical substances according to their chemical structures and functional groups for easy reference Includes updated information on the toxic, flammable, and explosive properties of chemical substances Covers additional metals in the chapters on toxic and reactive metals Updates the threshold exposure limits in the workplace air for a number of substances Features the latest information on industrial solvents and toxic and flammable gases Includes numerous tables, formulas, and a glossary for quick reference Because it provides information that enables those with a chemistry background to perform assessments without prior data, this comprehensive reference appeals to chemists, chemical engineers, toxicologists, and forensic scientists, as well as industrial hygienists, occupational physicians, Hazmat professionals, and others in related fields.
Author: David Baker Publisher: Oxford University Press ISBN: 9780199652549 Category : Medical Languages : en Pages : 368
Book Description
Essentials of Toxicology for Health Protection is a key handbook and course reader for all health protection professionals. It covers the basics of toxicology and its application to issues of topical concern including contaminated land, water pollution and traditional medicines.
Author: Richard P. Pohanish Publisher: William Andrew ISBN: 0815519044 Category : Medical Languages : en Pages : 2888
Book Description
For more than a quarter century, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens has proven to be among the most reliable, easy-to-use and essential reference works on hazardous materials. Sittig's 5th Edition remains the lone comprehensive work providing a vast array of critical information on the 2,100 most heavily used, transported, and regulated chemical substances of both occupational and environmental concern.Information is the most vital resource anyone can have when dealing with potential hazardous substance accidents or acts of terror. Sittig's provides extensive data for each of the 2,100 chemicals in a uniform format, enabling fast and accurate decisions in any situation. The chemicals are presented alphabetically and classified as a carcinogen, hazardous substance, hazardous waste, or toxic pollutant. This new edition contains extensively expanded information in all 28 fields for each chemical (see table of contents) and has been updated to keep pace with world events. Chemicals classified as WMD have been included in the new edition as has more information frequently queried by first responders and frontline industrial safety personnel.*Includes and references European chemical identifiers and regulations.*The only single source reference that provides such in-depth information for each chemical.*The two volume set is designed for fast and accurate decision making in any situation.
Author: H. Thomas
Author: H. Thomas
Author: Raymond D. Harbison
Author: Alice Hamilton
Author: K.L. Kaiser
Author: Ramesh C Gupta
Author: United States. Public Health Service. Office of the Surgeon General
Author: E.R. Plunkett
Author: Pradyot Patnaik
Author: David Baker
Author: Richard P. Pohanish