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Author: Antonio Peña-Fernández Publisher: ISBN: 9781032100227 Category : Chemicals Languages : en Pages :
Book Description
"There is an increasing need for knowledge of toxicology to safeguard the use of chemicals in industry, public and private sectors. The study of toxicology is becoming increasingly relevant in human health sciences, as future health and clinical professionals will be pivotal to address and manage emerging chemical threats and hazards related to modern anthropogenic activities and technological development. Comprising a series of chapters from leading toxicology, pharmacy and public health academics and experts across Europe, the United States and beyond, Toxicology for the Health and Pharmaceutical Sciences provides a concise yet comprehensive volume that can be used as a relevant textbook on toxicology for the clinical, healthcare, educational and professional sectors. This book covers the fundamentals and recent developments in toxicology, to respond to local and global chemical, pharmaceutical and environmental threats. Thus, this volume has chapters specifically designed to support the understanding of the most current, toxicology-related subjects for any undergraduate/postgraduate health programmes, as well as aiding with the delivery of continuing professional development training on up-to-date topics in toxicology for current practicing health professionals wishing to improve their background knowledge in toxicology. The book is also vital reading, and reference for policy makers, and others that influence, and decide regulations that have an impact on the environment, and human health"--
Author: Antonio Peña-Fernández Publisher: ISBN: 9781032100227 Category : Chemicals Languages : en Pages :
Book Description
"There is an increasing need for knowledge of toxicology to safeguard the use of chemicals in industry, public and private sectors. The study of toxicology is becoming increasingly relevant in human health sciences, as future health and clinical professionals will be pivotal to address and manage emerging chemical threats and hazards related to modern anthropogenic activities and technological development. Comprising a series of chapters from leading toxicology, pharmacy and public health academics and experts across Europe, the United States and beyond, Toxicology for the Health and Pharmaceutical Sciences provides a concise yet comprehensive volume that can be used as a relevant textbook on toxicology for the clinical, healthcare, educational and professional sectors. This book covers the fundamentals and recent developments in toxicology, to respond to local and global chemical, pharmaceutical and environmental threats. Thus, this volume has chapters specifically designed to support the understanding of the most current, toxicology-related subjects for any undergraduate/postgraduate health programmes, as well as aiding with the delivery of continuing professional development training on up-to-date topics in toxicology for current practicing health professionals wishing to improve their background knowledge in toxicology. The book is also vital reading, and reference for policy makers, and others that influence, and decide regulations that have an impact on the environment, and human health"--
Author: Antonio Peña-Fernández Publisher: CRC Press ISBN: 1351398016 Category : Medical Languages : en Pages : 531
Book Description
There is an increasing need for knowledge of toxicology to safeguard the use of chemicals in industry and in the public and private sectors. The study of toxicology is becoming increasingly relevant in human health sciences, as future health and clinical professionals will be pivotal in addressing and managing emerging chemical threats and hazards related to modern anthropogenic activities and technological development. Comprising a series of chapters from leading toxicology, pharmacy and public health academics and experts across Europe, the United States and beyond, Toxicology for the Health and Pharmaceutical Sciences provides a concise yet comprehensive volume that can be used as a relevant textbook on toxicology for the clinical, healthcare, educational and professional sectors. Key Features: Includes cutting edge information regarding the very lastest environmental threats to public health Provides a detailed case study based on a real-world scenario that allows the reader to practice human health risk assessment Describes innovative guidance and tools to respond to chemical incidents and attacks, which enables the reader to tailor an effective protection and remediation response This book covers the fundamentals and recent developments in toxicology, to respond to local and global chemical, pharmaceutical and environmental threats. Thus, this volume has chapters specifically designed to support the understanding of the most current toxicology-related subjects for any undergraduate/postgraduate health programs as well as aid the delivery of continuing professional development training on up-to-date topics in toxicology for current practicing health professionals wishing to improve their background knowledge in toxicology. The book is also vital reading and reference for policy makers and others that influence and set regulations that have an impact on the environment and human health.
Author: Chao Han Publisher: John Wiley & Sons ISBN: 0470044918 Category : Medical Languages : en Pages : 306
Book Description
Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development. Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume: Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics Address developability issues that challenge pharma companies, moving beyond isolated experimental results Reveal connections between the key scientific areas that are critical for successful drug discovery and development Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.
Author: Michael K. Pugsley Publisher: Springer ISBN: 366246943X Category : Medical Languages : en Pages : 477
Book Description
This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.
Author: Stephen M. Roberts Publisher: ISBN: 9783319190976 Category : Languages : en Pages :
Book Description
This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research. The book is divided into sub-sections with chapters on toxicological mechanisms, agents that produce toxicity, and special topics including areas such as antioxidant supplements, oxygen toxicity, toxicogenomics, and marine biology. Studies on Experimental Toxicology and Pharmacology promotes the concept of using biomarkers of free radical- and reactive species-induced injury as adjuncts to classical laboratory testing and the ability of antioxidants to provide cellular protection. There is increasing evidence that free radicals and other reactive species are causative, or at least supporting factors, that impact organisms and cause numerous tissue disorders. With contributions from international experts in the field, this volume is a valuable resource for researchers and postgraduate students in toxicology and related fields, as well as clinicians and clinical researchers.
Author: Yvonne Will Publisher: John Wiley & Sons ISBN: 1119053390 Category : Medical Languages : en Pages : 899
Book Description
As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
Author: Hugh MacPherson Publisher: Elsevier Health Sciences ISBN: 0443100292 Category : Medical Languages : en Pages : 288
Book Description
This is the first book to set out a full range of research strategies for evaluating the clinical practice of acupuncture. Leading acupuncturists and researchers with international reputations share their expertise. They illustrate their descriptions with practical examples of what has worked and what has not. It outlines many of the key challenges in the field. These challenges relate to the nature of acupuncture and the gap between current research evidence and the actual experiences of acupuncturists in the field. By focusing the chapters on key research questions, rather than methods, the book has a user-friendly feel. Each chapter is easily accessible with brief explanations of research designs as well as vignettes of relevant past research. The book is based on a deep understanding of acupuncture, with its inherent complexity in practice, whether based on traditional principles or more modern concepts. By incorporating a more sophisticated understanding of the field, this book details a range of strategies aiming to develop the evidence base with the utmost rigour. It is the first book on acupuncture research to take this unique view, integrating the very best of evidence-based medicine with a genuine sensitivity to the discipline of acupuncture, from its traditional and holistic roots to its more modern interpretations.
Author: Hans Marquardt Publisher: Academic Press ISBN: 0080543111 Category : Medical Languages : en Pages : 1355
Book Description
Toxicology is a comprehensive text for researchers and graduate students in toxicology and public health. It addresses every aspect of the field, starting with the fundamentals and incorporating such areas as organ toxicology, applications, and environmental toxicology. In addition to covering the traditional subject matter of toxicology, special emphasis has been placed on recent areas of interest, such as risk assessment, apoptosis, and methodical developments.Key Features* Comprehensive text, covering all aspects of the field of toxicology* Analyzes the importance of toxicokinetics and metabolism as well as cellular targets for the mechanisms of toxic effects* Identifies the various classes of chemical compounds responsible for the toxic effects* Describes the approaches and methods used by various disciplines which investigate toxic effects and their prevention* Adapted from a very successful German text, this edition is completely revised and expanded * The text is well illustrated with diagrams, charts, and tables
Author: Gerard J. Mulder Publisher: ISBN: Category : Business & Economics Languages : en Pages : 284
Book Description
Toxicology studies are carried out on all drug substances to ensure safety. This book provides an overview of the methodology andrequirements of pre-clinical safety assessments of new medicines. with the focus on medicinal drugs - the most important safety issues of drugs are covered, including registration requirements of new drugs and pharmacovigilance. This is an introductory text for students at BSc, MSc and PhD levels,and will be an excellent companion to pharmacology textbooks, combining a broad treatment of the issues relevant for assessing the safety/efficacy balance of a new drug wit
Author: Nancy A. Monteiro-Riviere Publisher: CRC Press ISBN: 1420079182 Category : Medical Languages : en Pages : 452
Book Description
This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barr
Author: Antonio Peña-Fernández
Author: Antonio Peña-Fernández
Author: Antonio Peña-Fernández
Author: Chao Han
Author: Michael K. Pugsley
Author: Stephen M. Roberts
Author: Yvonne Will
Author: Hugh MacPherson
Author: Hans Marquardt
Author: Gerard J. Mulder
Author: Nancy A. Monteiro-Riviere