Toxicity Report on Reproductive Dose Range-Finding Study of Genistein (CAS No. 446-72-0) Administered in Feed to Sprague-Dawley Rats PDF Download

Author: K. Barry Delclos
Publisher: DIANE Publishing
ISBN: 1428988807
Category : Medical
Languages : en
Pages : 320

View

Book Description
Genistein is a naturally occurring isoflavone that interacts with estrogen receptors & multiple other molecular targets. Human exposure to Genistein is through consumption of soy products, including soy-based infant formula & dietary supplements. A series of short-term studies with Genistein was conducted with two goals: to obtain data necessary to establish dose levels for subsequent multi-generation reproductive & chronic toxicity studies; & to evaluate the effects of Genistein on endpoints outside the reproductive tract. This report focuses on the reproductive & toxicology endpoints. Data obtained in separate evaluations of behavioral, neuroanatomical, neurochemical, & immunological endpoints are also discussed. Illustrations.

Author: D. A. Casciano
Publisher: DIANE Publishing
ISBN: 1437900739
Category : Health & Fitness
Languages : en
Pages : 242

View

Book Description
Genistein is an isoflavone that occurs in soy products incl. soy-based infant formulas. It is known as ¿environmental estrogens¿ which can affect the hormone activities and possibly reproductive function of wildlife and humans through exposure. Studies were conducted on 3 such chemicals to see if exposure to such chemicals could have any effect on animals¿ reproductive systems or development of cancers. Rats were exposed to genistein for part or all of the study period and examined at the end of 2 years. Exposure to Genistein for 2 years caused tumors of the mammary gland and pituitary gland in female rats. Exposure to Genistein for shorter durations was also assoc. with increased rates of pituitary gland and mammary gland tumors. Ill.

Author:
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 248

View

Book Description

Author: Philippa D. Darbre
Publisher: Academic Press
ISBN: 0128011203
Category : Medical
Languages : en
Pages : 390

View

Book Description
Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations

Author: Masayuki Miyasaka
Publisher: Springer
ISBN: 4431560688
Category : Medical
Languages : en
Pages : 679

View

Book Description
This book provides readers with the most up-to-date information on cutting-edge research concerning chronic inflammation. We now know that when inflammation becomes chronic, it acts as a strong disease-promoting factor in a variety of disorders including arteriosclerosis, obesity, cancer, and Alzheimer disease. Chronic inflammation is hence called as the “silent killer”; it upsets the body’s homeostatic mechanism insidiously. In spite of these developments, we know very little about the mechanism underlying chronic inflammation. Particularly, we do not know precisely what induces chronic inflammation or what promotes its prolongation in a spatiotemporal framework. Neither do we have clear knowledge about how chronic inflammation destroys various tissues or how it predisposes individuals to many different diseases. To make the situation worse, we have no effective treatment against chronic inflammation. Since 2010, two major research programs (CREST and PRESTO) aimed at clarifying the mechanisms underlying chronic inflammation were launched in Japan, and investigators of different research areas with a brilliant track record were selected by their research proposals. Subsequently they have made their best efforts to answer the conundrum concerning chronic inflammation. This book is a compendium of such research efforts. In each chapter, the CREST- or PRESTO-funded researchers summarize their original work concerning mechanisms of induction, progression, or resolution underlying chronic inflammation. The most emphasized characteristic is the molecular aspect of chronic inflammation. The book thus presents the most recent progress made in the molecular understanding of chronic inflammation.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309064198
Category : Science
Languages : en
Pages : 453

View

Book Description
Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Author: G. Sarwar Gilani
Publisher: The American Oil Chemists Society
ISBN: 9781893997325
Category : Health & Fitness
Languages : en
Pages : 682

View

Book Description

Author: Xiaodong Liu
Publisher: Springer Nature
ISBN: 9811376476
Category : Medical
Languages : en
Pages : 588

View

Book Description
This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.

Author: National Toxicology Program (U.S.)
Publisher:
ISBN:
Category : Toxicology
Languages : en
Pages : 512

View

Book Description

Author: Raja K Sivamani
Publisher: CRC Press
ISBN: 1482214172
Category : Medical
Languages : en
Pages : 460

View

Book Description
Cosmeceuticals and Active Cosmetics discusses the science of nearly two dozen cosmeceuticals used today. This third edition provides ample evidence on specific cosmeceutical substances, their classes of use, skin conditions for which they are used, and points of interest arising from other considerations, such as toxicology and manufacturing. The book discusses both cosmetic and therapeutic uses of cosmeceuticals for various conditions including rosacea, dry skin, alopecia, eczema, seborrheic dermatitis, purpura, and vitiligo. Active ingredients in the following products are discussed: caffeine, curcumin, green tea, Rhodiola rosea, milk thistle, and more. Also covered are topical peptides and proteins, amino acids and derivatives, antioxidants, vitamins E and C, niacinamide, botanical extracts, and biomarine actives. Providing ample scientific references, this book is an excellent guide to understanding the science behind the use of cosmeceuticals to treat a variety of dermatological conditions.