Tissue Engineering in Musculoskeletal Clinical Practice PDF Download

Author: Linda Jo Sandell
Publisher: American Academy of Orthopedic Surgeons
ISBN:
Category : Medical
Languages : en
Pages : 450

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Book Description
When will tissue-engineered materials be ready for the OR? How will they be introduced into clinics? What's available in the field now? Tissue Engineering answers these questions and brings insight into the potential for tissue engineering as a biological solution to the critical need for human tissues in orthopaedic surgery. This book is a compilation of the proceedings of the Tissue Engineering in Musculoskeletal Clinical Practice workshop held in Santa Fe, NM in January 2003. It is written by orthopaedic surgeons for practical application. Tissue Engineering addresses the present and future direction of the clinical, scientific and business aspects of the development and application of tissue engineered materials in orthopaedic surgery. Sections address clinical and marketing challenges, methodologies used in the construction of tissue engineered materials, as well as tissue engineering of bone, cartilage, ligament, tendon, meniscus, invertebral disk and muscle

Author: William S. Pietrzak
Publisher: Springer Science & Business Media
ISBN: 1597452394
Category : Medical
Languages : en
Pages : 647

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Book Description
The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts, this book aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. A valuable resource for researchers, developers, and clinicians, the book presents a foundation to propel the technology and integration of the current state of knowledge into the 21st century.

Author: Martin J. Stoddart
Publisher: Academic Press
ISBN: 0128115386
Category : Medical
Languages : en
Pages : 272

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Book Description
Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair

Author: Yupeng Chen
Publisher: Elsevier
ISBN: 0128242108
Category : Technology & Engineering
Languages : en
Pages : 385

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Book Description
Musculoskeletal Tissue Engineering introduces the fundamental concepts and translational applications of musculoskeletal tissue engineering, in combination with emerging technologies and materials. Sections discuss Tissues and Technologies, covering a range of musculoskeletal tissues, including bone, cartilage, ligament and more. Each chapter in this section details core tissue engineering principles specific to each tissue type. Next, a Technologies section looks at the range of biomaterials used in musculoskeletal tissue engineering, focusing on biocompatibility of materials and interactions at the material-tissue interface. Other chapters cover nanotechnology, 3D printing, gene therapy, tissue chips, and more. This book offers an advanced reference text for researchers in biomedical engineering, materials science and regenerative medicine. Details various materials and cutting-edge technologies for musculoskeletal tissue engineering Covers a range of musculoskeletal tissues, including bone, cartilage, ligament, tendon, meniscus, and more Provides a balance between basic concepts and translational applications for a broad audience

Author: Norbert Pallua
Publisher: Springer Science & Business Media
ISBN: 3642028241
Category : Medical
Languages : en
Pages : 632

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Book Description
Tissue engineering is a multidisciplinary field incorporating the principles of biology, chemistry, engineering, and medicine to create biological substitutes of native tissues for scientific research or clinical use. Specific applications of this technology include studies of tissue development and function, investigating drug response, and tissue repair and replacement. This area is rapidly becoming one of the most promising treatment options for patients suffering from tissue failure. This abundantly illustrated and well-structured guide serves as a reference for all clinicians and researchers dealing with tissue engineering issues in their daily practice.

Author: Syam Nukavarapu
Publisher: Woodhead Publishing
ISBN: 1782423141
Category : Science
Languages : en
Pages : 463

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Book Description
Repair and regeneration of musculoskeletal tissues is generating substantial interest within the biomedical community. Consequently, these are the most researched tissues from the regeneration point of view. Regenerative Engineering of Musculoskeletal Tissues and Interfaces presents information on the fundamentals, progress and recent developments related to the repair and regeneration of musculoskeletal tissues and interfaces. This comprehensive review looks at individual tissues as well as tissue interfaces. Early chapters cover various fundamentals of biomaterials and scaffolds, types of cells, growth factors, and mechanical forces, moving on to discuss tissue-engineering strategies for bone, tendon, ligament, cartilage, meniscus, and muscle, as well as progress and advances in tissue vascularization and nerve innervation of the individual tissues. Final chapters present information on musculoskeletal tissue interfaces. Comprehensive review of the repair and regeneration of musculoskeletal individual tissues and tissue interfaces Presents recent developments, fundamentals and progress in the field of engineering tissues Reviews progress and advances in tissue vascularization and innervation

Author: Yasser El Miedany
Publisher: Springer Nature
ISBN: 3030982564
Category : Medical
Languages : en
Pages : 554

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Book Description
The book examines recent developments in regenerative medicine and the use of musculoskeletal ultrasound. Musculoskeletal regeneration has become a prominent research topic, no doubt due to the sociological and economic pressures imposed by the current ageing population. The ever expanding role of regenerative medicine and the identification as well as characterization of stem cells have introduced a major paradigm shift in the field of musculoskeletal and sports medicine as well as orthopaedic surgery. Whereas in the past, diseased tissue was replaced with allograft material, current trends in research revolve around regenerating damaged tissue. Specifically, regenerative medicine stands in contrast to the standard treatment modalities which impair the body’s natural abilities to facilitate endogenous repair mechanisms such as anti-inflammatory drugs; or destructive modalities (e.g., radiotherapy, nerve ablation, injections of botulinum toxin) and surgical interventions that permanently alter the functioning of a joint, bone or spine. When compared to other allopathic options (including knee and hip arthroplasty with a 90-day mortality rate of 0.7%), regenerative medicine treatment modalities have a lower incidence of adverse events with a growing body of statistically significant medical literature illustrating both their safety and efficacy. Focusing on the major values of regenerative medicine, this book with its 21 chapters is expected to fill an important void in the current literature. It will take that extra step to guide you in your day to day clinical practice. Featuring contributions from a large international group of leaders in regenerative medicine and musculoskeletal ultrasonography, this book is an authoritative reference for rheumatologists, physiatrists, sonographers, radiologists, physiotherapists and orthopaedic specialists.

Author: Ulrich Meyer
Publisher: Springer Science & Business Media
ISBN: 3540777555
Category : Medical
Languages : en
Pages : 1049

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Book Description
"Fundamentals of Tissue Engineering and Regenerative Medicine" provides a complete overview of the state of the art in tissue engineering and regenerative medicine. Tissue engineering has grown tremendously during the past decade. Advances in genetic medicine and stem cell technology have significantly improved the potential to influence cell and tissue performance, and have recently expanded the field towards regenerative medicine. In recent years a number of approaches have been used routinely in daily clinical practice, others have been introduced in clinical studies, and multitudes are in the preclinical testing phase. Because of these developments, there is a need to provide comprehensive and detailed information for researchers and clinicians on this rapidly expanding field. This book offers, in a single volume, the prerequisites of a comprehensive understanding of tissue engineering and regenerative medicine. The book is conceptualized according to a didactic approach (general aspects: social, economic, and ethical considerations; basic biological aspects of regenerative medicine: stem cell medicine, biomolecules, genetic engineering; classic methods of tissue engineering: cell, tissue, organ culture; biotechnological issues: scaffolds; bioreactors, laboratory work; and an extended medical discipline oriented approach: review of clinical use in the various medical specialties). The content of the book, written in 68 chapters by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this bio-medical field.

Author: James Chang
Publisher: World Scientific
ISBN: 9814313556
Category : Medical
Languages : en
Pages : 284

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Book Description
Musculoskeletal applications of tissue engineering will be among the first to achieve widespread clinical use, and the resulting shift in clinical and surgical paradigms will highlight the need for an authoritative text on tissue engineering for musculoskeletal tissues including nerve, bone, tendon, skin, vessels, and cartilage. This book will serve the needs of a large readership including plastic surgeons, orthopedic surgeons, medical residents and medical students, researchers and academic faculty in regenerative medicine and biomedical engineering, and medical device experts. This textbook will serve as the curriculum for undergraduate and graduate courses in biomedical engineering and surgery. Notable contributors to this volume include Antonios G Mikos, PhD; Wei Liu, MD; Yilin Cao, MD; Mark Randolph, MAS; Jennifer Elisseeff, PhD; Geoffrey C Gurtner, MD; Michael T Longaker, MD; and James Chang, MD, all of whom are leaders in tissue engineering research and applications.

Author: Robert Lanza
Publisher: Elsevier
ISBN: 008053967X
Category : Science
Languages : en
Pages : 1039

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Book Description
The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field. Key Features* Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves* Essential to anyone working in the field* Educates and directs both the novice and advanced researcher* Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves* Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell* Considered the definitive reference in the field* List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others