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Author: Himanshu Shekhar Publisher: LAP Lambert Academic Publishing ISBN: 9783659316494 Category : Languages : en Pages : 112
Book Description
The book provides sufficient materials on thermodynamic analysis of binary organic systems forming eutectic solid dispersions and addition compounds with congruent and non-congruent melting points. The nature of molecular interaction, thermodynamic stability and ordering between components have also been described. With view to elucidate the Dermatological effect, nicotinamide based binary drug products have been suggested in this book. The critical size of nucleus at 1-3.5K undercooling has been found in nano scale which may lead a new challenge for pharmaceutical industries. The solid-liquid interface morphology of the binary product has been predicted in the light of Jackson's roughness parameters which suggests the faceted growth proceeds in all the binary drug products.
Author: Himanshu Shekhar Publisher: LAP Lambert Academic Publishing ISBN: 9783659316494 Category : Languages : en Pages : 112
Book Description
The book provides sufficient materials on thermodynamic analysis of binary organic systems forming eutectic solid dispersions and addition compounds with congruent and non-congruent melting points. The nature of molecular interaction, thermodynamic stability and ordering between components have also been described. With view to elucidate the Dermatological effect, nicotinamide based binary drug products have been suggested in this book. The critical size of nucleus at 1-3.5K undercooling has been found in nano scale which may lead a new challenge for pharmaceutical industries. The solid-liquid interface morphology of the binary product has been predicted in the light of Jackson's roughness parameters which suggests the faceted growth proceeds in all the binary drug products.
Author: Prof. I.P. Tripathi Publisher: International E Publication ISBN: 8183520049 Category : Medical Languages : en Pages : 248
Book Description
This book aims to discuss and practices all the issues pertaining to medicinal plants research, documentation, utilization. conservation activities, standardization, quality control, tissue culture, biotechnology, biochemistry, phytochemistry and chemical characterization taking place in various Universities, Institutions, Colleges and their impact on medicinal plants.
Author: Nianping Feng Publisher: Springer Nature ISBN: 9811634440 Category : Medical Languages : en Pages : 342
Book Description
This book describes the essential and cutting-edge concepts based on the frontier of pharmaceutical research in TCM, underlying scientific principles, and current advancements of drug delivery systems for Chinese medicines, including sustained-release drug delivery systems, trans-nasal drug delivery systems, dermal and transdermal drug delivery systems, etc. Novel carriers and emerging technologies (such as 3D printing) are also covered. The book provides readers with an overall picture of drug delivery systems for Chinese medicines and also yields benefits for the pharmaceutical industry with regard to TCM-based drug development.
Author: David J. am Ende Publisher: John Wiley & Sons ISBN: 1119285887 Category : Technology & Engineering Languages : en Pages : 1168
Book Description
A guide to the development and manufacturing of pharmaceutical products written for professionals in the industry, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry is a practical book that highlights chemistry and chemical engineering. The book’s regulatory quality strategies target the development and manufacturing of pharmaceutically active ingredients of pharmaceutical products. The expanded second edition contains revised content with many new case studies and additional example calculations that are of interest to chemical engineers. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The active pharmaceutical ingredients book puts the focus on the chemistry, chemical engineering, and unit operations specific to development and manufacturing of the active ingredients of the pharmaceutical product. The drug substance operations section includes information on chemical reactions, mixing, distillations, extractions, crystallizations, filtration, drying, and wet and dry milling. In addition, the book includes many applications of process modeling and modern software tools that are geared toward batch-scale and continuous drug substance pharmaceutical operations. This updated second edition: • Contains 30new chapters or revised chapters specific to API, covering topics including: manufacturing quality by design, computational approaches, continuous manufacturing, crystallization and final form, process safety • Expanded topics of scale-up, continuous processing, applications of thermodynamics and thermodynamic modeling, filtration and drying • Presents updated and expanded example calculations • Includes contributions from noted experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduate students, and professionals in the field of pharmaceutical sciences and manufacturing, the second edition of Chemical Engineering in the Pharmaceutical Industry focuses on the development and chemical engineering as well as operations specific to the design, formulation, and manufacture of drug substance and products.
Author: Gregory K. Webster Publisher: CRC Press ISBN: 9814745464 Category : Medical Languages : en Pages : 728
Book Description
This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.
Author: Andreas Klamt Publisher: Elsevier ISBN: 0080455530 Category : Technology & Engineering Languages : en Pages : 247
Book Description
The COSMO-RS technique is a novel method for predicting the thermodynamic properties of pure and mixed fluids which are important in many areas, ranging from chemical engineering to drug design. COSMO-RS, From Quantum Chemistry to Fluid Phase Thermodynamics and Drug Design is about this novel technology, which has recently proven to be the most reliable and efficient tool for the prediction of vapour-liquid equilibria. In contrast to group contribution methods, which depend on an extremely large number of experimental data, COSMO-RS calculates the thermodynamic data from molecular surface polarity distributions, resulting from quantum chemical calculations of the individual compounds in the mixture. In this book, the author cleverly combines a vivid overview of the partly demanding theoretical steps with a deeper analysis of their scientific background and justification. Aimed at theoretical chemists, computational chemists, physical chemists, chemical engineers, thermodynamicists as well as students,academic and industrial experts, COSMO-RS, From Quantum Chemistry to Fluid Phase Thermodynamics and Drug Design provides a novel viewpoint to anyone looking to gain more insight into the theory and potential of the unique method, COSMO-RS. - The only book currently available on COSMO-RS technique - Provides a novel viewpoint for the scientific understanding and for the practical quantitative treatment of fluid phase thermodynamics - Includes illustrative examples of the COSMOtherm program
Author: Yitzhak Marcus Publisher: CRC Press ISBN: 9780824708375 Category : Science Languages : en Pages : 282
Book Description
Compiling, comparing, and analyzing research from a wide range of abstracts, journal articles, and Web sites, this reference examines the properties, function, and behavior of binary, ternary, and multicomponent mixtures in the presence and absence of solutes. The author uniformly presents extensive data on the properties of solvent mixtures and describes their structures and interactions. He details the impact of preferential solvation on the environment, action, and components of chemical systems. The book highlights experimental approaches to determine when, and to what extent, preferential solvation has taken place and models for organic, ionic, macromolecular, and biochemical solutes.
Author: Stephen R. Byrn Publisher: John Wiley & Sons ISBN: 1119264448 Category : Science Languages : en Pages : 432
Book Description
Presents a detailed discussion of important solid-state properties, methods, and applications of solid-state analysis Illustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformation Covers key methods of solid state analysis including X-ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid state NMR Reviews critical physical attributes of pharmaceutical materials, mainly related to drug substances, including particle size/surface area, hygroscopicity, mechanical properties, solubility, and physical and chemical stability Showcases the application of solid state material science in rational selection of drug solid forms, analysis of various solid forms within drug substance and the drug product, and pharmaceutical product development Introduces appropriate manufacturing and control procedures using Quality by Design, and other strategies that lead to safe and effective products with a minimum of resources and time
Author: Himanshu Shekhar
Author: Himanshu Shekhar
Author: Prof. I.P. Tripathi
Author: Nianping Feng
Author: David J. am Ende
Author: Gregory K. Webster
Author: 
Author: Andreas Klamt
Author: 
Author: Yitzhak Marcus
Author: Stephen R. Byrn