Therapeutic Hypothermia to Reduce Intracranial Pressure After Traumatic Brain Injury PDF Download

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ISBN:
Category :
Languages : en
Pages :

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Author: Farid Sadaka
Publisher: BoD – Books on Demand
ISBN: 953510960X
Category : Medical
Languages : en
Pages : 163

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Book Description
This book describes the evidence behind the application of Therapeutic Hypothermia on patients with injury to the brain and spinal cord, that includes ischemia reperfusion after cardiac arrest or asphyxiation, traumatic brain injury, acute ischemic stroke, hemorrhagic stroke, refractory intracranial hypertension, cerebral edema in acute liver failure, subarachnoid hemorrhage, as well as spinal cord injury. This book discusses the mechanisms by which therapeutic hypothermia can mitigate the pathophysiologies responsible for secondary brain injury, and provides information to help guide this treatment with regard to timing, depth, duration, and management of side-effects. The book also discusses the methods and technologies used to induce and maintain therapeutic hypothermia. It also describes how hypothermia can influence the ability to prognosticate these injured patients and provides grounds for future directions in the application of and research with therapeutic hypothermia.

Author: Daniel Laskowitz
Publisher: CRC Press
ISBN: 1498766579
Category : Medical
Languages : en
Pages : 388

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Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

Author: Samuel Tisherman
Publisher: Springer Science & Business Media
ISBN: 038725403X
Category : Medical
Languages : en
Pages : 264

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Book Description
Therapeutic Hypothermia will provide a review of the subject, in particular, resuscitative hypothermia and include known mechanisms of action and results from both mechanistic and outcome laboratory studies and clinical trials. Cooling methods and potential side effects of hypothermia will be addressed as well as recommendations for future laboratory and clinical research. This volume will be of interest to both the researcher interested in therapeutic hypothermia as well as the clinician interested in the potential use of therapeutic hypothermia in their patient population.

Author: Roseleen F. John
Publisher:
ISBN:
Category : Hydrocephalus
Languages : en
Pages : 116

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Elevated intracranial pressure (ICP) is a potentially life threatening complication after intracerebral hemorrhagic stroke (ICH). Animal and clinical studies suggest that mild (~33oC) therapeutic hypothermia (TH) reduces ICP after ischemic stroke and traumatic brain injury (TBI). Since TH has also been shown to reduce edema after several neurological conditions, and edema is widely considered a key contributor to ICP, it is hypothesized that ICP management might be achieved through edema reduction. Thus, the current thesis evaluated the influence of brain-selective TH on ICP in a rat model of ICH. This thesis evaluated whether brain selective-cooling aggravated bleeding in the collagenase-induced ICH model, and tested whether brain cooling reduced ICP after ICH, or the re-warming rate mattered. ICP was measured for 4 days using telemetry pressure transmitters in untethered awake rats subjected to a large-collagenase induced ICH. Delayed cooling 24 hours after ICH did not worsen bleeding, and so TH treatment was delayed for 24 hours in all cooling experiments. Brain-selective hypothermia significantly reduced mean and peak ICP. On the contrary, fast-rewarming worsened edema on day 4, but this did not noticeably affect ICP responses. Lastly, increases in edema did not correlate with increases in ICP. These findings suggest that factors other than edema may better predict ICP, and further pre-clinical work is needed to provide better insight into cerebral pressure management.

Author: N. Hayashi
Publisher: Springer Science & Business Media
ISBN: 4431668829
Category : Medical
Languages : en
Pages : 253

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Rapid progress in technology and its application to diagnosis and monitoring of brain tissue temperature and metabolism have resulted in advances in the therapy for critically brain-injured patients and breakthroughs in understanding the pathophysiology of brain damage. The latest concept of brain hypothermia therapy clarifies targets such as brain thermal pooling, masking brain hypoxia associated with catecholamine surge, the metabolic shift from glucose to lipids, and selective radical damage of dopamine in the central nervous system. This volume explains the mechanism of brain injury and how brain hypothermia treatment differs from other hypothermia therapy in four major sections: Brain Injury Mechanism, Pathophysiology of Hypothermia, Basic Research of Hypothermia Treatment, and Clinical Studies of Brain Hypothermia. The book is a valuable source for practitioners and researchers in neurosurgery and neurology and in critical care and emergency medicine.

Author: Dan Greitz
Publisher:
ISBN: 9789162808563
Category :
Languages : en
Pages : 23

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Author: N. Hayashi
Publisher: Springer Science & Business Media
ISBN: 4431539611
Category : Medical
Languages : en
Pages : 352

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The International Brain Hypothermia Symposium 2004, held in Tokyo, was a forum for many of the world’s leading researchers and clinicians to present and discuss developments on the cutting edge of this most promising of neurological therapies. With a view to sharing this knowledge and encouraging the spread of new techniques, the editors have compiled these proceedings covering the latest technology and methods. Topics include brain thermo-pooling, hemoglobin-dysfunction-associated neuronal hypoxia, intensive care management of brain hypothermia for severely brain-injured patients, new findings not yet recorded in animal models, and control of hypothermia-associated immune crises. Also included are advanced clinical results from trauma, stroke, and cardiac arrest patients. The result is a volume that will be a valuable resource for professionals in the fields of emergency treatment, critical medicine, and neurosurgery.

Author: Charles Vacanti
Publisher: Cambridge University Press
ISBN: 1139498401
Category : Medical
Languages : en
Pages : 1191

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The clinical practice of anesthesia has undergone many advances in the past few years, making this the perfect time for a new state-of-the-art anesthesia textbook for practitioners and trainees. The goal of this book is to provide a modern, clinically focused textbook giving rapid access to comprehensive, succinct knowledge from experts in the field. All clinical topics of relevance to anesthesiology are organized into 29 sections consisting of more than 180 chapters. The print version contains 166 chapters that cover all of the essential clinical topics, while an additional 17 chapters on subjects of interest to the more advanced practitioner can be freely accessed at www.cambridge.org/vacanti. Newer techniques such as ultrasound nerve blocks, robotic surgery and transesophageal echocardiography are included, and numerous illustrations and tables assist the reader in rapidly assimilating key information. This authoritative text is edited by distinguished Harvard Medical School faculty, with contributors from many of the leading academic anesthesiology departments in the United States and an introduction from Dr S. R. Mallampati. This book is your essential companion when preparing for board review and recertification exams and in your daily clinical practice.

Author: S. Andrew Josephson
Publisher: Cambridge University Press
ISBN: 1139501828
Category : Medical
Languages : en
Pages :

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Over the past decade, the hospitalist model has become a dominant system for the delivery of inpatient care. Forces such as national mandates to improve safety and quality, and intense pressure to safely reduce length of hospital stays, are now exerting pressure on neurologists. To meet these challenges, a new neurohospitalist model is emerging. This is the first authoritative text to detail the advances and strategies for treating neurologic disease in a hospital setting. It includes chapters on specific acute neurologic diseases including stroke, epilepsy, neuromuscular disease and traumatic brain injury and also addresses common reasons for neurologic consultation in the hospital including encephalopathy, electrolyte disturbances and neurologic complications of pregnancy. Ethical and structural issues commonly encountered in neurologic inpatients are also addressed. This will be a key resource for any clinician or trainee caring for neurologic patients in the hospital including practising neurologists, internists and trainees across multiple subspecialities.