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Author: Alexander V. Yakubovich Publisher: Springer Science & Business Media ISBN: 3642225926 Category : Science Languages : en Pages : 130
Book Description
There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics. The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes.
Author: Alexander V. Yakubovich Publisher: Springer Science & Business Media ISBN: 3642225926 Category : Science Languages : en Pages : 130
Book Description
There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics. The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes.
Author: Minoru Fujimoto Publisher: Springer Science & Business Media ISBN: 1475727259 Category : Science Languages : en Pages : 256
Book Description
Intended for readers with some prior knowledge of condensed-matter physics, this text emphasises the basic physics behind spontaneous structural changes in crystals. Starting with the relevant thermodynamic principles, the author discusses the nature of order variables and their collective motion in a crystal lattice. He also goes on to describe experimental methods for modulated crystal structures and gives examples of structural changes in representative systems. Both a graduate text and reference work.
Author: Yi Mao Publisher: ISBN: Category : Languages : en Pages :
Book Description
To generalize the compact-to-extended conformational change induced by charge in macromolecules, analytical mean-field theories are developed to study the nature of this transition. The compact-to-extended transition induced by charge is found to be first-order in the presence of strong short-range interactions at low temperatures, and second-order if the short-range interactions are weak. The prediction is compared to the computer simulation of the exhaustive enumeration of all 12-mer cubic lattice polymer conformations using different potentials, and qualitative agreement is found. Implications for protein folding are discussed.
Author: V. I. Yukalov Publisher: World Scientific ISBN: 9789971504748 Category : Science Languages : en Pages : 262
Book Description
This book treats the problem of phase transitions, emphasizing the generality and universality of the methods and models used. The course is basically concentrated on the problems of vacuum degeneration in macroscopic systems and a fundamental concept of quasiaverages by Bogolubov playing a special role in the theory of phase transitions and critical phenomena. An analysis of the connection between phase transition and spontaneous symmetry breaking in a macroscopic system allows a unique description of both first- and second-order phase transitions.The unique features of this book are: (i) a unique approach of describing first ? as well as second-order phase transitions, based on the Bogolubov concept of quasi-averages.(ii) a detailed presentation of the material and at the same time a review of modern problems.(iii) a general character of developed ideas that could be applied to various particular systems of condensed matter physics, nuclear physics and high-energy physics.
Author: Moshe Gitterman Publisher: World Scientific Publishing Company ISBN: 9813106352 Category : Science Languages : en Pages : 145
Book Description
This book presents a short, fairly simple course on the basic theory of phase transitions and its modern applications. In physics, these applications include such modern developments as Bose-Einstein condensation of atoms, high temperature superconductivity, and vortices in superconductors, while in other fields they include small world phenomena and scale-free systems (such as stock markets and the Internet). The advantage of treating all these topics together lies in showing their connection with one another and with the general theory of phase transitions.
Author: Yurii Aleksandrovich Izyumov Publisher: Springer Science & Business Media ISBN: 9400919204 Category : Science Languages : en Pages : 462
Book Description
About half a century ago Landau formulated the central principles of the phe nomenological second-order phase transition theory which is based on the idea of spontaneous symmetry breaking at phase transition. By means of this ap proach it has been possible to treat phase transitions of different nature in altogether distinct systems from a unified viewpoint, to embrace the aforemen tioned transitions by a unified body of mathematics and to show that, in a certain sense, physical systems in the vicinity of second-order phase transitions exhibit universal behavior. For several decades the Landau method has been extensively used to an alyze specific phase transitions in systems and has been providing a basis for interpreting experimental data on the behavior of physical characteristics near the phase transition, including the behavior of these characteristics in systems subject to various external effects such as pressure, electric and magnetic fields, deformation, etc. The symmetry aspects of Landau's theory are perhaps most effective in analyzing phase transitions in crystals because the relevant body of mathemat ics for this symmetry, namely, the crystal space group representation, has been worked out in great detail. Since particular phase transitions in crystals often call for a subtle symmetry analysis, the Landau method has been continually refined and developed over the past ten or fifteen years.
Author: Nigel Goldenfeld Publisher: CRC Press ISBN: 0429973128 Category : Science Languages : en Pages : 313
Book Description
Covering the elementary aspects of the physics of phases transitions and the renormalization group, this popular book is widely used both for core graduate statistical mechanics courses as well as for more specialized courses. Emphasizing understanding and clarity rather than technical manipulation, these lectures de-mystify the subject and show precisely "how things work." Goldenfeld keeps in mind a reader who wants to understand why things are done, what the results are, and what in principle can go wrong. The book reaches both experimentalists and theorists, students and even active researchers, and assumes only a prior knowledge of statistical mechanics at the introductory graduate level.Advanced, never-before-printed topics on the applications of renormalization group far from equilibrium and to partial differential equations add to the uniqueness of this book.
Author: Moshe Gitterman Publisher: World Scientific Publishing Company ISBN: 9814520624 Category : Science Languages : en Pages : 211
Book Description
This book provides a comprehensive review of the theory of phase transitions and its modern applications, based on the five pillars of the modern theory of phase transitions: the Ising model, mean field, scaling, renormalization group and universality. This expanded second edition includes, along with a description of vortices and high temperature superconductivity, a discussion of phase transitions in chemical reactions and moving systems. The book covers the close connection between phase transitions and small world phenomena as well as scale-free systems such as the stock market and the Internet.
Author: Alexander V. Yakubovich
Author: Alexander V. Yakubovich
Author: Minoru Fujimoto
Author: Yi Mao
Author: V. I. Yukalov
Author: Moshe Gitterman
Author: Ming-Hong Hao
Author: Yurii Aleksandrovich Izyumov
Author: Nigel Goldenfeld
Author: I︠A︡kov Grigorʹevich Sinaĭ
Author: Moshe Gitterman