Theory and Production of Hyperpolarized Xenon Gas PDF Download

Author: Avner Fitterman
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description
Conventional magnetic resonance imaging (MRI) modality is based on the magnetization that is formed by the influence of a strong polarizing magnetic field on the spin of protons, typically those of water molecules within the body. In Hyperpolarized (HP) gas MRI, a dramatic increase in spin polarization is achieved using spin-exchange optical pumping (SEOP), which allows images to be obtained with a high signal-to-noise ratio (SNR). Batch-mode custom-built polarizers can serve to produce the HP gas, however, such custom-built systems require optimization in terms of pressure and temperature parameters. This study is comprised of three objectives: i) Gaining understanding regarding the physics of the nuclear polarization process of 129Xe; ii) Examining experimentally the pressure and temperature dependences of the polarization, similarly to the way it was done in previous studies; iii) Exploiting this knowledge for the benefit of the optimization of the custom-built polarizer in our lab.

Author: Thomas Meersmann
Publisher: Royal Society of Chemistry
ISBN: 1782628371
Category : Medical
Languages : en
Pages : 505

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Book Description
Providing the first comprehensive book on the current state of hyperpolarized Xenon-129 NMR and MRI, this book is guaranteed to appeal to a wide range of scientists interested in this growing field. It is intended to create synergy between the various communities working with this noble gas. Covering all topics from the production of the hyperpolarized gas to its applications, the editors have invited a leading team of experts to combine the physical chemistry within the various topics and across disciplines. The scope will range from the fundamental aspects of optical pumping to practical aspects of hyperpolarizers and hp-xenon handling. The applications section will focus on hyperpolarized xenon-129 detected in the dissolved phase or micro porous media where the chemical shift of xenon-129 can be used as a diagnostic probe. Appealing to researchers in the biomedical field and materials sciences, this reference book will provide background reading and future looking material in one place.

Author: Mitchell S. Albert
Publisher: Academic Press
ISBN: 0128037040
Category : Science
Languages : en
Pages : 334

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Book Description
Hyperpolarized and Inert Gas MRI: Theory and Applications in Research and Medicine is the first comprehensive volume published on HP gas MRI. Since the 1990's, when HP gas MRI was invented by Dr. Albert and his colleagues, the HP gas MRI field has grown dramatically. The technique has proven to be a useful tool for diagnosis, disease staging, and therapy evaluation for obstructive lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. HP gas MRI has also been developed for functional imaging of the brain and is presently being developed for molecular imaging, including molecules associated with lung cancer, breast cancer, and Alzheimer's disease. Taking into account the ongoing growth of this field and the potential for future clinical applications, the book pulls together the most relevant and cutting-edge research available in HP gas MRI into one resource. - Presents the most comprehensive, relevant, and accurate information on HP gas MRI - Co-edited by the co-inventor of HP gas MRI, Dr. Albert, with chapter authors who are the leading experts in their respective sub-disciplines - Serves as a foundation of understanding of HP gas MRI for researchers and clinicians involved in research, technology development, and clinical use with HP gas MRI - Covers all hyperpolarized gases, including helium, the gas with which the majority of HP gas MRI has been conducted

Author: Eul Hyun Suh
Publisher: Academic Press
ISBN: 0323918433
Category : Science
Languages : en
Pages : 266

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Book Description
The Chemistry of Hyperpolarized Magnetic Resonance Probes, Volume Seven focuses on the chemical aspects of hyperpolarized NMR/MRI technology, with synthesis and characterizations of labeled compounds discussed from a practical point-of-view. A brief overview of the various hyperpolarization techniques are given, with the optimization of hyperpolarization conditions and the determination of critical parameters such as polarization level and T1 relaxation values described. A practical guide on the in vivo applications of hyperpolarized compounds in small animals is also included. - Helps readers understand the structural features that determine the properties of HP-probes, such as chemical shift and relaxation times - Aids readers in selecting stable isotope labeled probes for hyperpolarized NMR/MRI applications - Teachers readers how to use the most appropriate synthetic methodology for the labeled probes - Covers how to find the most suitable polarization technique (DNP, PHIP etc.) for the probe

Author: Hans-Ulrich Kauczor
Publisher: Springer Science & Business Media
ISBN: 354034618X
Category : Medical
Languages : en
Pages : 315

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Book Description
During the past decade significant developments have been achieved in the field of magnetic resonance imaging (MRI), enabling MRI to enter the clinical arena of chest imaging. Standard protocols can now be implemented on up-to-date scanners, allowing MRI to be used as a first-line imaging modality for various lung diseases, including cystic fibrosis, pulmonary hypertension and even lung cancer. The diagnostic benefits stem from the ability of MRI to visualize changes in lung structure while simultaneously imaging different aspects of lung function, such as perfusion, respiratory motion, ventilation and gas exchange. On this basis, novel quantitative surrogates for lung function can be obtained. This book provides a comprehensive overview of how to use MRI for imaging of lung disease. Special emphasis is placed on benign diseases requiring regular monitoring, given that it is patients with these diseases who derive the greatest benefit from the avoidance of ionizing radiation.

Author: World Health Organization
Publisher: World Health Organization
ISBN: 924156346X
Category : Chronic diseases
Languages : en
Pages : 156

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Book Description
Chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease, kill more than 4 million people every year, and affect hundreds of millions more. These diseases erode the health and well-being of the patients and have a negative impact on families and societies. This report raises awareness of the huge impact of chronic respiratory diseases worldwide, and highlights the risk factors as well as ways to prevent and treat these diseases.

Author:
Publisher: Academic Press
ISBN: 0080922171
Category : Science
Languages : en
Pages : 7207

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Book Description
The Second Edition of the Encyclopedia of Spectroscopy and Spectrometry pulls key information into a single source for quick access to answers and/or in-depth examination of topics. "SPEC-2" covers theory, methods, and applications for researchers, students, and professionals—combining proven techniques and new insights for comprehensive coverage of the field. The content is available in print and online via ScienceDirect, the latter of which offers optimal flexibility, accessibility, and usability through anytime, anywhere access for multiple users and superior search functionality. No other work gives analytical and physical (bio)chemists such unprecedented access to the literature. With 30% new content, SPEC-2 maintains the "authoritative, balanced coverage" of the original work while also breaking new ground in spectroscopic research. Incorporates more than 150 color figures, 5,000 references, and 300 articles (30% of which are new), for a thorough examination of the field Highlights new research and promotes innovation in applied areas ranging from food science and forensics to biomedicine and health Features a new co-editor: David Koppenaal of Pacific Northwest National Laboratory, Washington, USA, whose work in atomic mass spectrometry has been recognized internationally

Author: G A Webb
Publisher: Royal Society of Chemistry
ISBN: 1847553877
Category : Science
Languages : en
Pages : 517

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Book Description
As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Author: Khan Maaz
Publisher: BoD – Books on Demand
ISBN: 9535129074
Category : Science
Languages : en
Pages : 366

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Book Description
Raman spectroscopy has a number of applications in various fields including material science, physics, chemistry, biology, geology, and medicine. This book illustrates necessary insight and guidance in the field of Raman spectroscopy with detailed figures and explanations. This presents deep understanding of new techniques from basic introduction to the advance level for scientists and engineers. The chapters cover all major aspects of Raman spectroscopy and its application in material characterization with special emphasis on both the theoretical and experimental aspects. This book is aimed to provide solid foundation of Raman spectroscopy to the students, scientists, and engineers working in various fields as mentioned above.

Author: Mark E. Limes
Publisher: Springer
ISBN: 3319136321
Category : Science
Languages : en
Pages : 151

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Book Description
This thesis describes longitudinal nuclear relaxation measurements of solid 129Xe near 77 K with previously unattainable reproducibility, and demonstrates differences in relaxation, dependent upon the way in which the solid is condensed. These results are directly applicable to the generation and storage of large quantities of hyperpolarized 129Xe for various applications, such as lung magnetic resonance imaging (MRI). The thesis features a sophisticated theoretical approach to these data sets, including modifications to a well-established Raman-phonon scattering theory that may explain the larger scatter in and discrepancies with previous work.