The Use of Delayed Neutron Counting for Uranium Analysis in Biological Tissue and Its Application to a Pharmacokinetic Study in Weanling Rats PDF Download
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Author: Philip D. Nelson Publisher: ISBN: Category : Uranium Languages : en Pages : 198
Book Description
Delayed neutron counting (DNC) is a variation of neutron activation analysis applicable only to fissionable elements. Briefly, it involves exposing a sample to the neutron flux in a reactor to induce fission, then quickly retrieving the sample to count the delayed fission neutrons emitted. These are proportional to the amount of the fissionable element in the sample. This technique has been used for over two decades to assay uranium in geological and water samples. I investigated its applicability to biological tissues, specifically soft tissues and bones. Only the simplest sample preparation was required. Samples needed only to be freeze dried, weighed and encapsulated in polyvials before activation. This allowed rapid preparation of large numbers of samples at low cost (about half that of conventional chemical analyses). The minimum level of detection (MLD) for 1/2 gram samples was about 10 nanograms for natural uranium. Precision was comparable to values attained for other methods of uranium analysis. Accuracy was determined by using a relative accuracy. Prepared standard solutions were analyzed for uranium content by an outside laboratory and then all counting data were compared to these values. The effects on precision and accuracy of a variety of factors in sample preparation, activation, and neutron counting were evaluated. DNC appears to have substantial advantages for uranium analysis over conventional methods, while achieving similar precision, accuracy, and MLD. The DNC method was used to study the uptake, distribution, and clearance of an acute dose of uranium in weanling rats. The dose was administered by gavage. Animals were killed and various tissues were collected at several times post gavage. The absorption of uranium in the GI tract occurred primarily in the stomach within 15 minutes, and appeared to be dependent upon the acidity of the stomach contents. Uranium absorbed from the GI tract entered the blood and deposited in the skeleton. Uptake and loss in the skeleton followed two patterns. A transitory uptake was observed in the skull, while a slower, longer term uptake associated with bone growth or degree of bone mineralization was observed in the remainder of the skeleton. Uptake and loss in the kidney followed a similar pattern as observed for the skeleton (excluding the skull). In addition, the relative distribution of uranium in the skeleton, i.e., the fractional burdens of the individual bones of the skeleton, appeared to be independent of time post gavage, age, route of administration, and sex.
Author: Philip D. Nelson Publisher: ISBN: Category : Uranium Languages : en Pages : 198
Book Description
Delayed neutron counting (DNC) is a variation of neutron activation analysis applicable only to fissionable elements. Briefly, it involves exposing a sample to the neutron flux in a reactor to induce fission, then quickly retrieving the sample to count the delayed fission neutrons emitted. These are proportional to the amount of the fissionable element in the sample. This technique has been used for over two decades to assay uranium in geological and water samples. I investigated its applicability to biological tissues, specifically soft tissues and bones. Only the simplest sample preparation was required. Samples needed only to be freeze dried, weighed and encapsulated in polyvials before activation. This allowed rapid preparation of large numbers of samples at low cost (about half that of conventional chemical analyses). The minimum level of detection (MLD) for 1/2 gram samples was about 10 nanograms for natural uranium. Precision was comparable to values attained for other methods of uranium analysis. Accuracy was determined by using a relative accuracy. Prepared standard solutions were analyzed for uranium content by an outside laboratory and then all counting data were compared to these values. The effects on precision and accuracy of a variety of factors in sample preparation, activation, and neutron counting were evaluated. DNC appears to have substantial advantages for uranium analysis over conventional methods, while achieving similar precision, accuracy, and MLD. The DNC method was used to study the uptake, distribution, and clearance of an acute dose of uranium in weanling rats. The dose was administered by gavage. Animals were killed and various tissues were collected at several times post gavage. The absorption of uranium in the GI tract occurred primarily in the stomach within 15 minutes, and appeared to be dependent upon the acidity of the stomach contents. Uranium absorbed from the GI tract entered the blood and deposited in the skeleton. Uptake and loss in the skeleton followed two patterns. A transitory uptake was observed in the skull, while a slower, longer term uptake associated with bone growth or degree of bone mineralization was observed in the remainder of the skeleton. Uptake and loss in the kidney followed a similar pattern as observed for the skeleton (excluding the skull). In addition, the relative distribution of uranium in the skeleton, i.e., the fractional burdens of the individual bones of the skeleton, appeared to be independent of time post gavage, age, route of administration, and sex.
Author: Wade H. Shafer Publisher: Springer Science & Business Media ISBN: 1468451979 Category : Science Languages : en Pages : 407
Book Description
Masters Theses in the Pure and Applied Sciences was first conceived, published, and disseminated by the Center for Information and Numerical Data Analysis and Synthesis (CINDAS) * at Purdue University in 1 957, starting its coverage of theses with the academic year 1955. Beginning with Volume 13, the printing and dissemination phases of the activity were transferred to University Microfilms/Xerox of Ann Arbor, Michigan, with the thought that such an arrangement would be more beneficial to the academic and general scientific and technical community. After five years of this joint undertaking we had concluded that it was in the interest of all con cerned if the printing and distribution of the volumes were handled by an interna tional publishing house to assure improved service and broader dissemination. Hence, starting with Volume 18, Masters Theses in the Pure and Applied Sciences has been disseminated on a worldwide basis by Plenum Publishing Cor poration of New York, and in the same year the coverage was broadened to include Canadian universities. All back issues can also be ordered from Plenum. We have reported in Volume 29 (thesis year 1984) a total of 12,637 theses titles from 23 Canadian and 202 United States universities. We are sure that this broader base for these titles reported will greatly enhance the value of this important annual reference work. While Volume 29 reports theses submitted in 1984, on occasion, certain univer sities do report theses submitted in previous years but not reported at the time.
Author: United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) Publisher: United Nations ISBN: 9210600029 Category : Political Science Languages : en Pages : 512
Book Description
This report assesses the levels and effects of exposure to ionizing radiation. Scientific findings underpin radiation risk evaluation and international protection standards. This report comprises a report with two underpinning scientific annexes. The first annex recapitulates and clarifies the philosophy of science as well as the scientific knowledge for attributing observed health effects in individuals and populations to radiation exposure, and distinguishes between that and inferring risk to individuals and populations from an exposure. The second annex reviews the latest thinking and approaches to quantifying the uncertainties in assessments of risk from radiation exposure, and illustrates these approaches with application to examples that are highly pertinent to radiation protection.
Author: John Risher Publisher: DIANE Publishing ISBN: 143793076X Category : Health & Fitness Languages : en Pages : 457
Book Description
Selenium (SE) and its compounds are used in photographic devices, gun gluing, plastics, paints, anti-dandruff shampoos, vitamin and mineral supp., fungicides, and glass. It is also used to prepare drugs and as a nutritional feed supp. for poultry and livestock. This profile includes: (a) The exam¿n. of toxicologic info. and epidemiologic evaluations on SE to ascertain the levels of significant human exposure for the substance and the chronic health effects; (b) A determination of whether adequate info. on the health effects of SE is avail. to determine levels of exposure that present a significant risk to human health (SRHH); and (c) Ident¿n. of toxicologic testing needed to identify the types of exposure that may present SRHH. Illus. A print on demand pub.
Author: Victor R. Preedy Publisher: Springer ISBN: 9086867286 Category : Science Languages : en Pages : 477
Book Description
Hair is a major component of the body's tissue system that contributes to the individual's make up and confers a large degree of personal identity. Apart from its visible façade, hair also has a functional role. It has an unique structure and complex molecular development. The very nature of hair makes it a suitable marker for the prognosis of disease. Hair can also be used to screen for toxins and changes in the diet. However, there are currently no suitable publications available that describe hair in a rational scientific context. This handbook provides an academic approach to hair in health and disease. Divided into five sections the Handbook of Hair in Health and Disease provides an insight into hair growth and loss, molecular and cellular biology of hair, dietary toxicity and pathological history, diseases and treatments of hair, as well as shampoos and conditioners. Unique features of each chapter in this volume include relevant and useful 'Key facts' which highlight interesting or important findings of the specific subjects and 'Summary points' that will give a clear overview of the subjects treated in each chapter. The Handbook of Hair in Health and Disease will be essential to a variety of users, such as trichologists, doctors and nurses and all those interested or working within the area of hair health. This includes nutritionists and dieticians, scientific beauticians, health workers and practitioners, college and university lecturers and undergraduate and graduate students.
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans Publisher: ISBN: Category : Accidents, Radiation Languages : en Pages : 620
Book Description
Evaluates the evidence for carcinogenicity of ionizing radiation from internally deposited radionuclides. The radionuclides considered belong to two broad categories, those that emit a-particles (helium nuclei) and those that emit b-particles (electrons).
Author: Elżbieta Kalisińska Publisher: Springer ISBN: 3030001210 Category : Science Languages : en Pages : 708
Book Description
The population explosion that began in the 1960s has been accompanied by a decrease in the quality of the natural environment, e.g. pollution of the air, water and soil with essential and toxic trace elements. Numerous poisonings of people and animals with highly toxic anthropogenic Hg and Cd in the 20th century prompted the creation of the abiotic environment, mainly in developed countries. However, the system is insufficient for long-term exposure to low concentrations of various substances that are mainly ingested through food and water. This problem could be addressed by the monitoring of sentinels – organisms that accumulate trace elements and as such reflect the rate and degree of environmental pollution. Usually these are long-lived vertebrates – herbivorous, omnivorous and carnivorous birds and mammals, especially game species. This book describes the responses of the sentinels most commonly used in ecotoxicological studies to 17 trace elements.
Author: Philip D. Nelson
Author: Philip D. Nelson
Author: Wade H. Shafer
Author: United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR)
Author: 
Author: John Risher
Author: 
Author: Victor R. Preedy
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Author: Arthur L. Frank
Author: Elżbieta Kalisińska