The Unblinding PDF Download

Author: Laurence Lieberman
Publisher: New York : Macmillan
ISBN:
Category : American poetry
Languages : en
Pages : 104

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Author: Traci Medford-Rosow
Publisher: Morgan James Publishing
ISBN: 1683507835
Category : Biography & Autobiography
Languages : en
Pages : 179

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Book Description
The USA Today–bestselling biography of a man who lost his sight as an adult and regained it twenty years later without any medical intervention. Unblinded is the true story of New Yorker Kevin Coughlin, who became blind at age thirty-six due to a rare genetic disorder known as Leber’s Hereditary Optic Neuropathy. Twenty years later, without medical intervention, Kevin’s sight miraculously started to return. He is the only known person in the world who has experienced a spontaneous, non-medically assisted, regeneration of the optic nerve. Unblinded follows Kevin’s descent into darkness, and his unexplained reemergence to sight. Praise for Unblinded “A remarkable story of sudden blindness, new vision, and sight regained. It offers great insight into the nature of reality—that which we perceive and that which we create for ourselves.”—Isaac Lidsky, New York Times–bestselling author of Eyes Wide Open “Its pages take us, at once, on a remarkable true adventure and into the heart and mind of a most extraordinary individual. A beautifully written and inspiring tale, and a reminder to us all about what really matters.”—Robert Kurson, New York Times–bestselling author of Rocket Men “Unblinded provides honest, profound insight into the emotional trauma that occurs when vision is lost and the path forward in life cannot be seen.”—Lissa Poincenot, National Leber’s Hereditary Optic Neuropathy Advocate “A fascinating, behind-the-scenes tour of what went on during those years of darkness and how Kevin Coughlin, after battling alcoholism, loneliness, prejudice, and perhaps most of all himself, emerges as a man of wisdom and sight.”—Ann Campanella, award-winning and bestselling author of Motherhood: Lost and Found

Author: Anton Bespalov
Publisher: Springer Nature
ISBN: 3030336565
Category : Cardiology
Languages : en
Pages : 424

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Book Description
This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

Author: Robert A. Parker
Publisher: Cambridge University Press
ISBN: 0521840635
Category : Mathematics
Languages : en
Pages : 445

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Book Description
Planning clinical research requires many decisions. The authors of this book explain key decisions with examples showing what works and what does not.

Author: National Research Council
Publisher: National Academies Press
ISBN: 030918651X
Category : Medical
Languages : en
Pages : 163

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Book Description
Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.

Author: Peter G. Smith
Publisher:
ISBN: 0198732864
Category : Health & Fitness
Languages : en
Pages : 479

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Book Description
This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309316324
Category : Medical
Languages : en
Pages : 236

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Book Description
Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.

Author: Susanne Prokscha
Publisher: CRC Press
ISBN: 1040042112
Category : Medical
Languages : en
Pages : 266

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Book Description
The management of clinical data, from its collection during a trial to its extraction for analysis, has become critical in preparing a regulatory submission and obtaining approval to market a treatment. Groundbreaking on its initial publication nearly 14 years ago, and evolving with the field in each iteration since then, this latest volume includes revisions to all chapters to reflect the recent updates to ICH E6, good clinical practices, electronic data capture, and interactive response technologies. Keeping the coverage practical, the author focuses on the most critical information that impacts clinical trial conduct, providing a full end-to-end overview for clinical data managers. Features: Provides an introduction and background information for the spectrum of clinical data management tasks. Outstanding text in the industry and has been used by the Society for Clinical Data Management in creating its certification exam. Explains the high-level flow of a clinical trial from creation of the protocol through study lock. Reflects electronic data capture and interactive response technologies. Discusses using the concept of three phases in the clinical data management of a study: study startup, study conduct, and study closeout, to write procedures and train staff.

Author: Matt Blaze
Publisher: Springer Science & Business Media
ISBN: 3540365044
Category : Computers
Languages : en
Pages : 310

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Book Description
The Sixth International Financial Cryptography Conference was held during March 11-14, 2002, in Southampton, Bermuda. As is customary at FC, these proceedings represent "final" versions of the papers presented, revised to take into account comments and discussions from the conference. Submissions to the conference were strong, with 74 papers submitted and 19 accepted for presentation and publication. (Regrettably, three of the submit ted papers had to be summarily rejected after it was discovered that they had been improperly submitted in parallel to other conferences.) The small program committee worked very hard under a tight schedule (working through Christmas day) to select the program. No program chair could ask for a better committee; my thanks to everyone for their hard work and dedication. In addition to the refereed papers, the program included a welcome from the Minister of Telecommunications and e-Commerce, Renee Webb, a keynote address by Nigel Hickson, and a panel on privacy tradeoffs cheiired by Rebecca Wright (with panelists Ian Goldberg, Ron Rivest, and Graham Wood). The traditional Tuesday evening "rump session" was skillfully officiated by Markus Jakobsson. My job as program chair was made much, much easier by the excellent work of our general chair, Nicko van Someren, who performed the miracle of hiding from me any evidence of the innumerable logistical nightmares associated with conducting this conference. I have no idea how he did it, but it must have involved many sleepless nights.

Author: Liqun Chen
Publisher: Springer
ISBN: 3319991361
Category : Computers
Languages : en
Pages : 520

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Book Description
This book constitutes the proceedings of the 21st International Conference on Information Security, ISC 2018, held in Guildford, UK, in September 2018. The 26 full papers presented in this volume were carefully reviewed and selected from 59 submissions. The book also includes one invited talk in full-paper length. The papers were organized in topical sections named: software security; symmetric ciphers and cryptanalysis; data privacy and anonymization; outsourcing and assisted computing; advanced encryption; privacy-preserving applications; advanced signatures; and network security.