Author: Brian Dean ThompsonPublisher:
ISBN:
Category :
Languages : en
Pages : 698
Book Description
The Total Synthesis of (+/- )-epoxysorbicillinol and Progress Toward the Total Synthesis of (+)-epoxysorbicillinol
Author: Brian Dean ThompsonProgress Toward the Total Synthesis of Superstolide A
Author: Jennifer A. ChampouxProgress Toward the Total Synthesis of (+)-hitachimycin (stubomycin)
Author: Thomas Anthony RanoProgress Towards the Total Synthesis of Chlorothricolide
Author: Steven Edward HallPublisher:
ISBN:
Category : Diels-Alder reaction
Languages : en
Pages : 344
Book Description
Total Synthesis of Kellermanoldione, 3-deoxyconferdione, and Progress Towards the Total Synthesis of Epi-conferdione
Author: Jesus CordovaThe First Total Synthesis of ()-lemonomycin and Progress Toward the Total Synthesis of (+)-cyanocycline A
Author: Eric Robert AshleyPublisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages : 658
Book Description
Progress Toward the Total Synthesis of the Epoxyquinoid Family of Natural Products
Author: Publisher:
ISBN:
Category :
Languages : en
Pages : 228
Book Description
Enyne metathesis is a powerful C-C bond forming reaction that combines an alkene and an alkyne and forms a conjugated 1,3-diene. The scope of enyne metathesis was expanded by combining various alkynes with vinyl ethers. Typically vinyl ethers are poor metathesis substrates, but a method was developed for the synthesis of dienol ethers utilizing ruthenium carbenes. The products of these reactions were subjected to [4+2] cycloaddition conditions to give substituted cyclohexene rings. The epoxyquinoid family is a highly targeted series of natural products. A general method for the synthesis of the core structure of these natural products has been explored. An enyne cross metathesis/ring closing metathesis step was designed as the key reaction to this synthesis. A Darzen's condensation between a chiral [alpha]-alkoxy aldehyde and a chloroacyl oxazolidinone was successfully employed to join two fragments of the molecule as well as to install an epoxide. A highly diastereoselective cuprate addition set the stereochemistry of the first stereogenic center. The early intermediates were prepared via easily scalable organic syntheses procedures including utilizing a carbohydrate as the source of chirality. Ring closing enyne metathesis to form the epoxyquinoid core was evaluated in two epimeric series.
Progress Towards the Total Synthesis of Cribrostatin 4
Author: Richard HeidNew Methods and Strategies for Heterocycle Synthesis
Author: Kurt Jay KiewelPart 1: Progress Toward the Total Synthesis of Platensimycin. Part 2: Aromatic Ions: Carbon-Based Nucleofuges and Chiral Cyclopropenones and Formamides
Author: Ethan Lawrence FisherPublisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
The third chapter describes the synthesis of chiral cyclopropenones and their use in the kinetic resolution of alcohols by chlorodehydration. Chiral formamides are also studied for their use in chlorodehydration. Transition states for enantiodifferentiation are proposed.