The Thyroid Gland and Tail Regeneration in the Lizard, Anolis Carolinensis PDF Download

Author: James Eldridge Turner
Publisher:
ISBN:
Category :
Languages : en
Pages : 74

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Author: Mary Cabrini Angelli
Publisher:
ISBN:
Category :
Languages : en
Pages : 56

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Author: John Patrick Card
Publisher:
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Category : Biological control systems
Languages : en
Pages : 60

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Author: Jeffrey S. Scehnet
Publisher:
ISBN:
Category :
Languages : en
Pages : 78

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Author: Elizabeth Hutchins
Publisher:
ISBN:
Category : Bioinformatics
Languages : en
Pages : 119

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Damage to the central nervous system due to spinal cord or traumatic brain injury, as well as degenerative musculoskeletal disorders such as arthritis, drastically impact the quality of life. Regeneration of complex structures is quite limited in mammals, though other vertebrates possess this ability. Lizards are the most closely related organism to humans that can regenerate de novo skeletal muscle, hyaline cartilage, spinal cord, vasculature, and skin. Progress in studying the cellular and molecular mechanisms of lizard regeneration has previously been limited by a lack of genomic resources. Building on the release of the genome of the green anole, Anolis carolinensis, we developed a second generation, robust RNA-Seq-based genome annotation, and performed the first transcriptomic analysis of tail regeneration in this species. In order to investigate gene expression in regenerating tissue, we performed whole transcriptome and microRNA transcriptome analysis of regenerating tail tip and base and associated tissues, identifying key genetic targets in the regenerative process. These studies have identified components of a genetic program for regeneration in the lizard that includes both developmental and adult repair mechanisms shared with mammals, indicating value in the translation of these findings to future regenerative therapies.

Author: Lorenzo Alibardi
Publisher: Springer Science & Business Media
ISBN: 364203733X
Category : Medical
Languages : en
Pages : 117

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The present review covers a very neglected field in regeneration studies, namely, tissue and organ regeneration in reptiles, especially represented by the lizard model of regeneration. The term “regeneration” is intended here as “the ability of an adult organism to recover damaged or completely lost body parts or organs.” The process of recovery is further termed “restitutive regeneration” when the lost part is reformed and capable of performing the complete or partial physiological activity performed by the original, lost body part. Lizards represent the only amniotes that at the same time show successful organ regeneration, in the tail, and organ failure, in the limb (Marcucci 1930a, b; Simpson 1961, 1970, 1983). This condition offers a unique opportunity to study at the same time mechanisms that in different regions of the same animal control the success or failure of regeneration. The lizard model is usually neglected in the literature despite the fact that the lizard is an amniote with a basic histological structure similar to that of mammals, and it is therefore a better model than the salamander (an a- mniote) model to investigate regeneration issues.

Author: Michael John Maher
Publisher:
ISBN:
Category : Thyroid gland
Languages : en
Pages : 148

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Author: Prentiss Gwendolyn Cox
Publisher:
ISBN:
Category :
Languages : en
Pages : 392

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Author: Carl Gans
Publisher: Wiley-Interscience
ISBN:
Category : Nature
Languages : en
Pages : 760

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Volume 15 concentrates on the Squamata (lizards and snakes) and includes reproductive patterns, caudal autotomy and regeneration, limb development and reduction, the development of reproductive patterns, parthenogenesis, viviparity and placentation.

Author:
Publisher:
ISBN:
Category : Anatomy, Comparative
Languages : en
Pages : 304

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