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Author: Navjeet Kaur Publisher: CRC Press ISBN: 1351242598 Category : Medical Languages : en Pages : 462
Book Description
This book is a compilation of the recent applications of palladium catalysts in organic synthesis. The book demonstrates that it is a highly dynamic research field. This methodology has emerged as a powerful tool for the efficient and chemoselective synthesis of heterocyclic molecules. In the past few years, several strategies have been pointed out to pursue more efficient, sustainable, and environment friendly chemical processes. Among those strategies, catalysis and the design of new processes that avoid the use of toxic reagents have been the focus of intense research.
Author: Navjeet Kaur Publisher: CRC Press ISBN: 1351242598 Category : Medical Languages : en Pages : 462
Book Description
This book is a compilation of the recent applications of palladium catalysts in organic synthesis. The book demonstrates that it is a highly dynamic research field. This methodology has emerged as a powerful tool for the efficient and chemoselective synthesis of heterocyclic molecules. In the past few years, several strategies have been pointed out to pursue more efficient, sustainable, and environment friendly chemical processes. Among those strategies, catalysis and the design of new processes that avoid the use of toxic reagents have been the focus of intense research.
Author: Wei Zhang Publisher: John Wiley & Sons ISBN: 1119288584 Category : Science Languages : en Pages : 1127
Book Description
An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.
Author: Romano V. A. Orru Publisher: Springer ISBN: 3642154557 Category : Science Languages : en Pages : 304
Book Description
Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery
Author: Árpád Molnár Publisher: John Wiley & Sons ISBN: 3527648305 Category : Science Languages : en Pages : 531
Book Description
This handbook and ready reference brings together all significant issues of practical importance in selected topics discussing recent significant achievements for interested readers in one single volume. While covering homogeneous and heterogeneous catalysis, the text is unique in focusing on such important aspects as using different reaction media, microwave techniques or catalyst recycling. It also provides a comprehensive treatment of key issues of modern-day coupling reactions having emerged and matured in recent years and emphasizes those topics that show potential for future development, such as continuous flow systems, water as a reaction medium, and catalyst immobilization, among others. With its inclusion of large-scale applications in the pharmaceutical industry, this will equally be of great interest to industrial chemists. From the contents * Palladium-Catalyzed Cross-Coupling Reactions - A General Introduction * High-turnover Heterogeneous Palladium Catalysts in Coupling Reactions: the Case of Pd Loaded on Dealuminated Y Zeolites Palladium-Catalyzed Coupling Reactions with Magnetically Separable Nanocatalysts * The Use of Ordered Porous Solids as Support Materials in Palladium-Catalyzed Cross-Coupling Reactions * Coupling Reactions Induced by Polymer-Supported Catalysts * Coupling Reactions in Ionic Liquids * Cross-Coupling Reactions in Aqueous Media * Microwave-Assisted Synthesis in C-C and C-Heteroatom Coupling Reactions * Catalyst Recycling in Palladium-Catalyzed Carbon-Carbon Coupling Reactions * Nature of the True Catalytic Species in Carbon-Carbon Coupling Reactions with * Heterogeneous Palladium Precatalysts * Coupling Reactions in Continuous Flow Systems * Large-Scale Applications of Palladium-Catalyzed Couplings in the Pharmaceutical Industry
Author: Ei-ichi Negishi Publisher: John Wiley & Sons ISBN: 0471473812 Category : Science Languages : en Pages : 1657
Book Description
Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.
Author: Andrei K. Yudin Publisher: John Wiley & Sons ISBN: 3527633405 Category : Science Languages : en Pages : 541
Book Description
Written by an experienced editor widely acclaimed within the scientific community, this book covers everything fromo9xygen to nitrogen functionalities. From the contents: Palladium-Catalyzed Syntheses of Five-Member Saturated Heterocyclic and of Aromatic Heterodynes Palladium-Catalysis for Oxidative 1, 2-Difunctionalization of Alkenes Rhodium-Catalyzed Amination of C-H-Bonds Carbon-Heteroatom Bond Formation by RH(I)-Catalyzed Ring-Opening Reactions Transition Metal-Catalyzed Synthesis of Lactones and of Monocyclic and Fused Five-Membered Aromatic heterocycles the Formation of Carbon-Sulfur and Carbon-Selenium bonds by Substitution and Addition reactions catalyzed by Transition Metal Complexes New Reactions of Copper Acetylides Gold Catalyzed Addition of Nitrogen, Sulfur and Oxygen Nucleophiles to C-C Multiple Bonds. The result is an indispensable source of information for the Strategic Planning of the Synthetic routes for organic, catalytic and medicinal chemists, as well as chemists in industry.
Author: Navjeet Kaur Publisher: Elsevier ISBN: 0443134243 Category : Science Languages : en Pages : 442
Book Description
Synthesis of Five-Membered Heterocycles: Role of DMF as Solvent, Reagent, Catalyst, and Stabilizer helps readers quickly assess possible synthetic approaches. The book's audience, researchers, academic professionals and synthetic chemists both in industry and academia will find detailed information about the synthesis of five-membered heterocyclic compounds using dimethylformamide. Over the years, heterocyclic compounds, especially five-membered, have drawn more attention of pharmaceutical community because of their therapeutic value. The formation of heterocyclic compounds has turned out to be the keystone of synthetic organic chemistry. Dimethylformamide has played an important role in organic synthesis for a long time, and it is frequently utilized as a common solvent for chemical reactions and broadly used in industry as a reagent. It is a unique chemical and can play three other roles in organic chemistry, i.e., as stabilizer, reagent and catalyst. Due to its structure, DMF can participate in several reactions as a versatile building block for several units. - Includes comprehensive descriptions of heterocycle synthesis - Highlights many methods for the synthesis of five-membered heterocyclic compounds using dimethylformamide - Helps readers quickly assess possible synthetic approaches
Author: Daniel Sole Publisher: Academic Press ISBN: 0128116528 Category : Science Languages : en Pages : 368
Book Description
Advances in Transition-Metal Mediated Heterocyclic Synthesis provides an overview of recent catalytic reactions involving transition metals to produce heterocyclic compounds. The book is organized according to the type of transformation used to achieve the synthesis of the heterocyclic systems (mainly aza- and oxa-heterocycles). As such, it covers recent applications on the synthesis of heterocycles, also describing the details of the novel transformations in a didactic manner to motivate readers in search of new catalytic processes. The editors have included state-of-the-art strategies, including transition-metal reactions involving unsaturated systems (reactions of allenes, new gold(I)-catalyzed reactions, and Prins reaction). Chapters highlight the versatility of organopalladium chemistry dealing with carbonylative transformations, C-H activation reactions, coupling processes, and the control of the ambiphilic character of organopalladium species. Finally, the book discusses new reactions leading to heterocycles based on C-H activation processes catalyzed by other metals (Rh, Ru, Co). Written by an outstanding team of authors who are leading experts in organometallic chemistry and organic synthesis, this book is a valuable resource not only for chemists mainly focused on synthesis, but also for those interested in reaction mechanisms involving transition metals. - Helpfully organized by transformation type to stimulate the search for new synthetic processes - Completely illustrated and written by global experts - Includes thoughtfully selected strategies chosen by the editors to exemplify the state-of-the-art of the subject, including transition-metal reactions involving unsaturated systems, organopalladium chemistry, and metal-catalyzed C-H activation
Author: Navjeet Kaur Publisher: Elsevier ISBN: 0443189420 Category : Science Languages : en Pages : 502
Book Description
5-Membered Heterocycle Synthesis Using Iodine presents both old and new methods for the synthesis of various five-membered heterocycles using iodine, providing information for making specific compounds using particular reagents. Heterocyclic frameworks represent the main structural subunits of many biologically active compounds and natural products, and the ability of heterocycles to act both as reactive pharmacophores and biomimetics has greatly contributed to their unique value as traditional key elements of various drugs. Contemporary developments in process chemistry and discovery emphasize novel sustainable synthetic pathways as fast and ecologically acceptable alternatives to the traditional protocols. This book serves as a guide for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals to obtain easy access to synthetic protocols for different five-membered heterocycles using iodine. - Covers the applications of five-membered heterocycles - Highlights methodologies for the synthesis of five-membered heterocycles using iodine - Contains the most up-to-date information in this fast-moving field
Author: Navjeet Kaur
Author: Navjeet Kaur
Author: Wei Zhang
Author: Romano V. A. Orru
Author: Jiro Tsuji
Author: Árpád Molnár
Author: Ei-ichi Negishi
Author: Andrei K. Yudin
Author: Navjeet Kaur
Author: Daniel Sole
Author: Navjeet Kaur