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Author: Alexander G. Bearn Publisher: Oxford University Press, USA ISBN: Category : Biography & Autobiography Languages : en Pages : 258
Book Description
In this scholarly and insightful biography, Alexander G. Bearn, a physician and a scientist in the Garrodian tradition, has drawn a portrait of one of the great minds of twentieth century medicine. It is story of intellectual achievement. But the book also gives a fascinating account of the life of a talented professional family and a perspective on the practice of medicine and on medical education at the turn of the century. Archibald Garrod is chiefly remembered as the originator of the concept of inborn metabolic error, an idea which grew from his studies of families with diseases whose biochemical basis he was able to identify. He was widely recognized for this achievement in his own lifetime and held a respected position in the medical establishment, a position accorded to him on the basis of his scientific achievement rather than for any great clinical skill. But to concentrate on the concept of inborn errors is to overlook what has in time turned out to be Garrod's greatest achievement, for it was he who first saw that genetics, biochemistry, and medicine are fundamentally linked. He propounded, to all who would listen, his thesis that disease can only be properly studied in the light of an individual's genetic susceptibility, and that that in turn rests on biochemical individuality. Only by thinking of human diseases as the consequences of genetic and environmental interaction are the advances of today's and tomorrow's medicine possible.
Author: Alexander G. Bearn Publisher: Oxford University Press, USA ISBN: Category : Biography & Autobiography Languages : en Pages : 258
Book Description
In this scholarly and insightful biography, Alexander G. Bearn, a physician and a scientist in the Garrodian tradition, has drawn a portrait of one of the great minds of twentieth century medicine. It is story of intellectual achievement. But the book also gives a fascinating account of the life of a talented professional family and a perspective on the practice of medicine and on medical education at the turn of the century. Archibald Garrod is chiefly remembered as the originator of the concept of inborn metabolic error, an idea which grew from his studies of families with diseases whose biochemical basis he was able to identify. He was widely recognized for this achievement in his own lifetime and held a respected position in the medical establishment, a position accorded to him on the basis of his scientific achievement rather than for any great clinical skill. But to concentrate on the concept of inborn errors is to overlook what has in time turned out to be Garrod's greatest achievement, for it was he who first saw that genetics, biochemistry, and medicine are fundamentally linked. He propounded, to all who would listen, his thesis that disease can only be properly studied in the light of an individual's genetic susceptibility, and that that in turn rests on biochemical individuality. Only by thinking of human diseases as the consequences of genetic and environmental interaction are the advances of today's and tomorrow's medicine possible.
Author: Elizabeth Hanson Publisher: Rockefeller Univ. Press ISBN: Category : Medical Languages : en Pages : 166
Book Description
Outstanding researchers have made The Rockefeller Institute, later renamed the Rockefeller University, the home of great events in science. This small institution generated lines of research that have remained productive and important for a century.
Author: René Jules Dubos Publisher: Rockefeller Univ. Press ISBN: Category : Biography & Autobiography Languages : en Pages : 270
Book Description
Oswald Theodore Avery is little known outside of the scientific community. Yet, this extraordinary man, here brought vividly to life by a perceptive friend and sophisticated scientific colleague, was a monumental force in the development of medical research in the United States. Even among scientists, Avery is known chiefly as the senior author of a paper published in 1944 that identified DNA as the purveyor of genetic information. Two things make this highly personalized biography a landmark volume. First, its technical chapters clarify the philosophical concepts that lie behind today's understanding of the immunology of bacterial infection. Second, not a single existing textbook has ever described the laborious methods by which the men in Avery's laboratory discovered the genetic import of DNA.
Author: Beth N. Orcutt Publisher: Cambridge University Press ISBN: 1108477496 Category : Nature Languages : en Pages : 687
Book Description
A comprehensive guide to carbon inside Earth - its quantities, movements, forms, origins, changes over time and impact on planetary processes. This title is also available as Open Access on Cambridge Core.
Author: C. Hannaway Publisher: IOS Press ISBN: 1607503085 Category : Medical Languages : en Pages : 388
Book Description
Biomedicine in the Twentieth Century: Practices, Policies, and Politics is a testimony to the growing interest of scholars in the development of the biomedical sciences in the twentieth century and to the number of historians, social scientists and health policy analysts now working on the subject. The book is comprised of essays by noted historians and social scientists that offer insights on a range of subjects that should be a significant stimulus for further historical investigation. It details the NIH’s practices, policies and politics on a variety of fronts, including the development of the intramural program, the National Institute of Mental Health and mental health policy, the politics and funding of heart transplantation and the initial focus of the National Cancer Institute. Comparisons can be made with the development of other American and British institutions involved in medical research, such as the Rockefeller Institute and the Medical Research Council. Discussions of the larger scientific and social context of United States’ federal support for research, the role of lay institutions in federal funding of virus research, the consequences of technology transfer and patenting, the effects of vaccine and drug development and the environment of research discoveries all offer new insights and suggest questions for further exploration.
Author: Inderjeet Parmar Publisher: Columbia University Press ISBN: 0231517939 Category : History Languages : en Pages : 369
Book Description
Inderjeet Parmar reveals the complex interrelations, shared mindsets, and collaborative efforts of influential public and private organizations in the building of American hegemony. Focusing on the involvement of the Ford, Rockefeller, and Carnegie foundations in U.S. foreign affairs, Parmar traces the transformation of America from an "isolationist" nation into the world's only superpower, all in the name of benevolent stewardship. Parmar begins in the 1920s with the establishment of these foundations and their system of top-down, elitist, scientific giving, which focused more on managing social, political, and economic change than on solving modern society's structural problems. Consulting rare documents and other archival materials, he recounts how the American intellectuals, academics, and policy makers affiliated with these organizations institutionalized such elitism, which then bled into the machinery of U.S. foreign policy and became regarded as the essence of modernity. America hoped to replace Britain in the role of global hegemon and created the necessary political, ideological, military, and institutional capacity to do so, yet far from being objective, the Ford, Rockefeller, and Carnegie foundations often advanced U.S. interests at the expense of other nations. Incorporating case studies of American philanthropy in Nigeria, Chile, and Indonesia, Parmar boldly exposes the knowledge networks underwriting American dominance in the twentieth century.
Author: Conrad Keating Publisher: Rutgers University Press ISBN: 1978801408 Category : Biography & Autobiography Languages : en Pages : 219
Book Description
Since the turn of the new millennium, ‘translational research’, the scientific process of bringing disease-targeted knowledge from the laboratory to treat patients in the clinic, has gone mainstream and is now practiced by large universities and institutes across the globe. Into this dynamic of the rapidly changing world of translational medical research this book sets the life of one of the discipline’s most influential practitioners, Anthony Cerami. His work spans more than five decades and culminated in the discovery, invention and development of diagnostics and therapeutics used daily by millions of people. Students in molecular medicine and investigators pursuing basic science in the hope of improving human health will find inspiration in examining the sacrifices and achievements of Cerami’s career in translational medicine. During his three decades at Rockefeller University his cross-disciplinary and laboratory-without-wall approach established ‘rational drug design’ as the most effective means of advancing the fields of parasitology, hematology, immunology, metabolism, therapeutics and molecular medicine. Cerami’s story and that of the evolution of translation are intimately entwined: the contours of Cerami’s career shaped by developments in translation, and in exchange, the field itself molded by Cerami’s work. To understand one is to understand the other. By examining the life of this often overlooked biochemist it is possible to intimately focus on the ideas and thought processes of a scientist who has helped to define the great acceleration in translational research over the past half century – research that, knowingly or otherwise, has most likely affected the life of almost everyone on the planet. We also gain a better understanding of the febrile creative atmosphere that percolated through the laboratories leading the way in translational medicine, and gain insight into the art, science, successes, failures and providence that underlie major scientific breakthroughs. Anybody interested in the questions of where modern medicines come from, how health outcomes around the globe are affected by research and imagination, and where the future of drug discovery is leading, will be rewarded by exploring Cerami’s life in translation. This book is not restricted to those with a professional interest in science, because anyone dedicated to living a life of creativity and discovery will be rewarded by reading this book. In many respects, Cerami’s life reflects the modern metaphor of the ‘American dream’ with his journey from humble beginnings on a chicken farm in rural New Jersey, to occupying a place in the highest echelons of the US scientific establishment. His journey in translational medicine was propelled forward by two obsessions; the idea that he could help people who were sick, and the excitement of discovery. In following his two great passions, he trained a generation of specialists in translational medicine that continue to transform our understanding of, and treatments for, human disease. Anthony Cerami’s work has shown how science has become an important force for social change by laying the foundations of modern translational medicine.
Author: Robert Lefkowitz Publisher: Simon and Schuster ISBN: 1643136399 Category : Biography & Autobiography Languages : en Pages : 304
Book Description
The rollicking memoir from the cardiologist turned legendary scientist and winner of the Nobel Prize that revels in the joy of science and discovery. Like Richard Feynman in the field of physics, Dr. Robert Lefkowitz is also known for being a larger-than-life character: a not-immodest, often self-deprecating, always entertaining raconteur. Indeed, when he received the Nobel Prize, the press corps in Sweden covered him intensively, describing him as “the happiest Laureate.” In addition to his time as a physician, from being a "yellow beret" in the public health corps with Dr. Anthony Fauci to his time as a cardiologist, and his extraordinary transition to biochemistry, which would lead to his Nobel Prize win, Dr. Lefkowitz has ignited passion and curiosity as a fabled mentor and teacher. But it's all in a days work, as Lefkowitz reveals in A Funny Thing Happened on the Way to Stockholm, which is filled to the brim with anecdotes and energy, and gives us a glimpse into the life of one of today's leading scientists.
Author: Alexander G. Bearn
Author: Alexander G. Bearn
Author: Elizabeth Hanson
Author: René Jules Dubos
Author: 
Author: Suzanne Grant Lewis
Author: Beth N. Orcutt
Author: C. Hannaway
Author: Inderjeet Parmar
Author: Conrad Keating
Author: Robert Lefkowitz