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Author: David M. Paton Publisher: Elsevier ISBN: 1483136523 Category : Science Languages : en Pages : 406
Book Description
The Release of Catecholamines from Adrenergic Neurons focuses on the processes involved in determining the release of catecholamines from neurons, noting the influence of alcohols, analgesics, and acids in the release. The selection first discusses biochemical and ultrastructural studies of the mechanism of release, as well as release of constituents of noradrenergic vesicles upon nerve stimulation; constituents of noradrenergic vesicles; and mechanism of release. The book then takes a look at the role of calcium in catecholamine release from adrenergic nerve terminals and presynaptic adrenoceptors and regulation of release. Topics include calcium-dependent versus calcium-independent noradrenaline release; differences between the presynaptic and postsynaptic alpha-adrenoceptors; and influence of neuronal uptake of noradrenaline on the negative feedback mechanism mediated by presynaptic alpha-adrenoceptors. The publication reviews presynaptic muscarine receptors and inhibition of release, including muscarinic inhibition of noradrenaline release evoked by electrical stimulation of sympathetic nerves; effect of muscarinic agonists on noradrenaline releasing procedures independent of calcium ions; and possible physiological and pharmacological significance of the muscarinic inhibitory mechanism. The text also ponders on the role of prostaglandins, cyclic adenosine monophate, analgesics, peptides, acids, anesthetics, and alcohols in the release. The selection is a dependable reference for readers interested in the study of the release of catecholamines from adrenergic neurons.
Author: David M. Paton Publisher: Elsevier ISBN: 1483136523 Category : Science Languages : en Pages : 406
Book Description
The Release of Catecholamines from Adrenergic Neurons focuses on the processes involved in determining the release of catecholamines from neurons, noting the influence of alcohols, analgesics, and acids in the release. The selection first discusses biochemical and ultrastructural studies of the mechanism of release, as well as release of constituents of noradrenergic vesicles upon nerve stimulation; constituents of noradrenergic vesicles; and mechanism of release. The book then takes a look at the role of calcium in catecholamine release from adrenergic nerve terminals and presynaptic adrenoceptors and regulation of release. Topics include calcium-dependent versus calcium-independent noradrenaline release; differences between the presynaptic and postsynaptic alpha-adrenoceptors; and influence of neuronal uptake of noradrenaline on the negative feedback mechanism mediated by presynaptic alpha-adrenoceptors. The publication reviews presynaptic muscarine receptors and inhibition of release, including muscarinic inhibition of noradrenaline release evoked by electrical stimulation of sympathetic nerves; effect of muscarinic agonists on noradrenaline releasing procedures independent of calcium ions; and possible physiological and pharmacological significance of the muscarinic inhibitory mechanism. The text also ponders on the role of prostaglandins, cyclic adenosine monophate, analgesics, peptides, acids, anesthetics, and alcohols in the release. The selection is a dependable reference for readers interested in the study of the release of catecholamines from adrenergic neurons.
Author: A. Amery Publisher: Springer Science & Business Media ISBN: 9400974760 Category : Medical Languages : en Pages : 1002
Book Description
Hypertension is a major world-wide health problem. With high blood pressure there is a greater risk of stroke, heart attack, heart failure, kidney disease and renal failure. Far too few people realize what the risks are and what can be done to prevent these risks even in the countries where pro grams in hypertension research are active and the full significance of hyper tension is best understood. Some studies of the known hypertensive popu lation indicate that one-half or less are receiving adequate treatment, and, of those on therapy, only half have their high blood pressure satisfactorily controlled. These realizations emphasize the need to inform all segments of society throughout the world on the importance of detection and control of high blood pressure. The great incidence of hypertension makes it of para mount importance that all practicing physicians have available the latest information on diagnosis and treatment of hypertensive cardiovascular dis ease. This treatise on hypertension arrives at a time when there is an increasing recognition the world over of the importance of detecting and treating high blood pressure. The book has been edited by Dr. A. Amery and his asso ciates in the University of Leuven. Professor Amery is one of the leaders in the field of hypertension and serves on the Council of the International Society of Hypertension.
Author: Alan A. Boulton Publisher: Humana ISBN: Category : Medical Languages : en Pages : 616
Book Description
Techniques in the neurosciences are evolving rapidly. There are currently very few volumes dedicated to the methodology - ployed by neuroscrentists, and those that are available often seem either out of date or limited in scope. This series is about the methods most widely used by modern-day neuroscientists and 1s written by their colleagues who are practicing experts. Volume 1 will be useful to all neuroscientists since it concerns those procedures used routinely across the widest range of s- drsciplines. Collecting these general techniques together in a single volume stnkes us not only as a service, but will no doubt prove of exceptional utilitarian value as well. Volumes 2 and 3 describe all current procedures for the analyses of ammes and theirmetabolites and of amino acrds, respectively. These collections will clearly be of value to all neuroscientists working in or contemplating research in these fields. Similar reasons exist for Volume 4 on receptor binding techniques since experimental details are provided for many types of ligand-receptor binding, including chapters on general prin- ples, drug discovery and development, and a most useful app- dix on computer programs for Scatchard, nonlinear, and compe- tive displacement analyses. Volume 5 provides procedures for the assessment of enzymes involved in biogenic amine synthesis and catabolism. Volumes in the NEUROMETHODS series will be useful to neurochemists, -pharmacologists, -physrologists, -anatomists, psychopharmacologists, psychiatrists, neurologists, and chemists (organic, analytical, pharmaceutical, medicinal); in fact, everyone involved in the neurosciences, both basic and clinical.
Author: Robert Vink Publisher: University of Adelaide Press ISBN: 0987073052 Category : Medical Languages : en Pages : 354
Book Description
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Author: Federico Bermudez-Rattoni Publisher: CRC Press ISBN: 1420008412 Category : Psychology Languages : en Pages : 368
Book Description
A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Author: Yogesh Dwivedi Publisher: CRC Press ISBN: 143983881X Category : Medical Languages : en Pages : 485
Book Description
With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.
Author: David M. Paton
Author: David M. Paton
Author: Hans-Joachim Schümann
Author: Geoffrey Burnstock and Marcello Costa
Author: David Murray Paton
Author: A. Amery
Author: Alan A. Boulton
Author: Earl Usdin
Author: Robert Vink
Author: Federico Bermudez-Rattoni
Author: Yogesh Dwivedi