The Regulatory Role of the Nervous System in Aging PDF Download

Author: Herman T. Blumenthal
Publisher: S. Karger AG (Switzerland)
ISBN:
Category : Medical
Languages : en
Pages : 140

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Author: Gerontological Society
Publisher:
ISBN:
Category :
Languages : en
Pages : 122

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Author: Stephen W. Scheff
Publisher: Springer Science & Business Media
ISBN: 1461327059
Category : Medical
Languages : en
Pages : 228

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The mammalian central nervous system is a remarkable structure which has attracted many new investigators, as evidenced by the dramatic increase in scientific publications dealing with neurobiology. Every day basic scientists conduct new and exciting experiments, resulting in remarkable discoveries des tined to help mankind. Unfortunately many of these new findings are slow to be accepted by the clinical world. This is especially true in the area of brain trauma, where the present prognosis is usually very poor. We have known for quite some time that the mammalian central nervous system is capable of compensating for severe damage in many different ways, and under some circumstances behav ioral compensation can be observed. However, much is still to be learned about the various factors and events that lead to functional recovery and those condi tions that do not. It is this challenge that originally excited a number of the contributors to this volume to explore the subject of recovery from brain damage. One factor in particular that is known to change the prognosis of recovery is the age of the organism at the time of the damage. This book is an attempt to explore this important variable. Most of the literature concerning aging deals with widespread degenerative changes and paints a grim picture for the aging central nervous system in terms of recovery of function following trauma.

Author: Jean Lauder
Publisher: Springer Science & Business Media
ISBN: 1475758766
Category : Science
Languages : en
Pages : 320

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The rapidly expanding fields of molecular and cellular neurobiology are the newest frontiers of neuroscience. This book represents the continuing efforts of the Institute of Developmental Neuroscience and Aging (IDNA) to disseminate the most recent advances on the developing and aging nervous system at the molecular and cellular levels. A group of neuroscientists presented and discussed their findings at a recent IDNA conference held in Athens, Greece, June 15-18, 1988. This meeting was sponsored by the National Hellenic Research Foundation, FIDIA, the Ministry of Research and Technology, the Tourism Organization of Greece, and the National Institute of Child Health and Human Development, NIH. The Directors of the IDNA are grateful to the local committee, Drs. Eleni Fleischer, Costas Sekeris, Michael Alexis, Theony Valcana, and Elias Kouvelas, for their efforts in organizing this meeting and for their successful integration of science and culture for the participants. This volume provides a comprehensive overview of the information presented at this conference, including in-depth discussions of each topic by the participants. The chapters are grouped into five general categories which correspond to the subject areas covered during the meeting. These include: Gene and Phenotypic Expression, Growth Factors and Oncogenes, Cytoskeletal and Extracellular Molecules, Neurotransmitters and Hormones, and Molecular Aspects of Aging and Alzheimer's Disease. The section on Gene and Phenotypic Expression includes discussions of transient gene expression in the nervous system (Herschman), developmental regulation of myelin-associated genes (Gordon et al.

Author: Maynard H. Makman
Publisher: Pergamon
ISBN:
Category : Medical
Languages : en
Pages : 232

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Aging and its associated problems are of increasing interest and concern as the life expectancy of the human population increases. The importance of continued functioning of the nervous system in cognitive and integrative processes, necessary for maintaining the quality of life during aging, is self evident. The nature and extent of the changes that occur with increasing age different considerably in different species and also in the various organs or tissues within a given species. emphasis on normal aging, as it applies to the nervous systems of man and other mammals, as well as to certain invertebrates. Changes in human brain function due to Alzheimer s disease are considered in addition to changes that may occur with normal human acing. The potential involvement of immunocytes in age-associated disorders is also discussed. nervous system, generally, due to aging, from molecular, pharmacological, electrophysiological and behavioral perspectives. This book emphasizes the attempts of recent research to understand the basic mechanisms for these changes, as well as their functional consequences and provides important insight into our understanding of the aging process and the consequences of these changes for neuronal function. Topics considered include neuropeptides systems in aging, including opioids and analgesic, cholinergic and aminergic systems, neuroendocrinology and neuroimmunology.

Author: Patrick R. Hof
Publisher: Elsevier
ISBN: 008052558X
Category : Medical
Languages : en
Pages : 989

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Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. Organized by function, making it easy to find and understand the material Addresses impairments both associated with diseases and not associated with diseases Written by leading researchers in the field Most comprehensive source of information on the neurobiology of aging

Author: David R. Riddle
Publisher: CRC Press
ISBN: 9781420005523
Category : Medical
Languages : en
Pages : 408

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Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Author: Vladimir Veniaminovich Frolʹkis
Publisher: S. Karger AG (Switzerland)
ISBN:
Category : Aging
Languages : en
Pages : 146

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Author: National Research Council
Publisher: National Academies Press
ISBN: 0309172195
Category : Social Science
Languages : en
Pages : 285

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Possible new breakthroughs in understanding the aging mind that can be used to benefit older people are now emerging from research. This volume identifies the key scientific advances and the opportunities they bring. For example, science has learned that among older adults who do not suffer from Alzheimer's disease or other dementias, cognitive decline may depend less on loss of brain cells than on changes in the health of neurons and neural networks. Research on the processes that maintain neural health shows promise of revealing new ways to promote cognitive functioning in older people. Research is also showing how cognitive functioning depends on the conjunction of biology and culture. The ways older people adapt to changes in their nervous systems, and perhaps the changes themselves, are shaped by past life experiences, present living situations, changing motives, cultural expectations, and emerging technology, as well as by their physical health status and sensory-motor capabilities. Improved understanding of how physical and contextual factors interact can help explain why some cognitive functions are impaired in aging while others are spared and why cognitive capability is impaired in some older adults and spared in others. On the basis of these exciting findings, the report makes specific recommends that the U.S. government support three major new initiatives as the next steps for research.

Author: Ayanna K. Thomas
Publisher: Cambridge University Press
ISBN: 1108690742
Category : Psychology
Languages : en
Pages : 1019

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Decades of research have demonstrated that normal aging is accompanied by cognitive change. Much of this change has been conceptualized as a decline in function. However, age-related changes are not universal, and decrements in older adult performance may be moderated by experience, genetics, and environmental factors. Cognitive aging research to date has also largely emphasized biological changes in the brain, with less evaluation of the range of external contributors to behavioral manifestations of age-related decrements in performance. This handbook provides a comprehensive overview of cutting-edge cognitive aging research through the lens of a life course perspective that takes into account both behavioral and neural changes. Focusing on the fundamental principles that characterize a life course approach - genetics, early life experiences, motivation, emotion, social contexts, and lifestyle interventions - this handbook is an essential resource for researchers in cognition, aging, and gerontology.