The Physical-Organic Chemistry of Surfaces, and Its Relevance to Molecular Recognition PDF Download
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Author: Publisher: ISBN: Category : Languages : en Pages : 22
Book Description
Understanding the interactions between liquids and the surfaces of organic solids is important for the study of molecular recognition. One method for studying these interactions is based on a physical organic approach: formation of well characterized organic surfaces and comparison of the contact angles of liquids on these surfaces. The technique of self-assembly provides an excellent route for the syntheses of organic surfaces; alkanethiols, for example, self-assemble from solutions to form monolayers on gold. Properties of these monolayers, including their thickness and their wettability by water, can be controlled by manipulating the structure and functionality of the molecules used to form the monolayer. The wettability of monolayers on gold formed from HS(CH2)(n)CH3 or HS(CH2)110(CH2)(n)CH3, where n is the number of methylene groups, depends only on the composition the outermost 5-10 A angstroms of the monolayer. The wettability of monolayers formed from mixtures of HS(CH2)11CH3 and HS(CH2)21CH3 depends both on the structure of the outermost part of the monolayer and the structure of the liquid. These and other results suggest that this physical-organic approach has and will continue to provide valuable insight into molecular recognition. Keywords: Biocompatibility, Proteins, Ligands, Biochemistry. (AW).
Author: Publisher: ISBN: Category : Languages : en Pages : 22
Book Description
Understanding the interactions between liquids and the surfaces of organic solids is important for the study of molecular recognition. One method for studying these interactions is based on a physical organic approach: formation of well characterized organic surfaces and comparison of the contact angles of liquids on these surfaces. The technique of self-assembly provides an excellent route for the syntheses of organic surfaces; alkanethiols, for example, self-assemble from solutions to form monolayers on gold. Properties of these monolayers, including their thickness and their wettability by water, can be controlled by manipulating the structure and functionality of the molecules used to form the monolayer. The wettability of monolayers on gold formed from HS(CH2)(n)CH3 or HS(CH2)110(CH2)(n)CH3, where n is the number of methylene groups, depends only on the composition the outermost 5-10 A angstroms of the monolayer. The wettability of monolayers formed from mixtures of HS(CH2)11CH3 and HS(CH2)21CH3 depends both on the structure of the outermost part of the monolayer and the structure of the liquid. These and other results suggest that this physical-organic approach has and will continue to provide valuable insight into molecular recognition. Keywords: Biocompatibility, Proteins, Ligands, Biochemistry. (AW).
Author: A.D. Buckingham Publisher: Springer Science & Business Media ISBN: 9401121680 Category : Science Languages : en Pages : 213
Book Description
The importance of molecular recognition in chemistry and biology is reflected in a recent upsurge in relevant research, promoted in particular by high-profile initiatives in this area in Europe, the USA and Japan. Although molecular recognition is necessarily microscopic in origin, its consequences are de facto macroscopic. Accordingly, a text that starts with intermolecular interactions between simple molecules and builds to a discussion of molecular recognition involving larger scale systems is timely. This book was planned with such a development in mind. The book begins with an elementary but rigorous account of the various types of forces between molecules. Chapter 2 is concerned with the hydrogen bond between pairs of simple molecules in the gas phase, with particular reference to the preferred relative orientation of the pair and the ease with which this can be distorted. This microscopic view continues in chapter 3 wherein the nature of interactions between solute molecules and solvents or between two or more solutes is examined from the experimental standpoint, with various types of spectroscopy providing the probe of the nature of the interactions. Molecular recognition is central to the catalysis of chemical reactions, especially when bonds are to be broken and formed under the severe con straint that a specific configuration is to result, as in the production of enan tiotopically pure compounds. This important topic is considered in chapter 4.
Author: Saul G. Cohen Publisher: John Wiley & Sons ISBN: 0470172029 Category : Science Languages : en Pages : 401
Book Description
Progress in Physical Organic Chemistry is dedicated to reviewing the latest investigations into organic chemistry that use quantitative and mathematical methods. These reviews help readers understand the importance of individual discoveries and what they mean to the field as a whole. Moreover, the authors, leading experts in their fields, offer unique and thought-provoking perspectives on the current state of the science and its future directions. With so many new findings published in a broad range of journals, Progress in Physical Organic Chemistry fills the need for a central resource that presents, analyzes, and contextualizes the major advances in the field. The articles published in Progress in Physical Organic Chemistry are not only of interest to scientists working in physical organic chemistry, but also scientists working in the many subdisciplines of chemistry in which physical organic chemistry approaches are now applied, such as biochemistry, pharmaceutical chemistry, and materials and polymer science. Among the topics explored in this series are reaction mechanisms; reactive intermediates; combinatorial strategies; novel structures; spectroscopy; chemistry at interfaces; stereochemistry; conformational analysis; quantum chemical studies; structure-reactivity relationships; solvent, isotope and solid-state effects; long-lived charged, sextet or open-shell species; magnetic, non-linear optical and conducting molecules; and molecular recognition.
Author: Stanley M. Roberts Publisher: ISBN: Category : Science Languages : en Pages : 308
Book Description
This book consists of articles which describe work involved in determining small molecule/large molecule interactions. It highlights the interactions of an enzyme with a substrate, and gives a detailed understanding of this recognition. More specifically it covers the importance of understanding the energetics of intra- and inter- molecular interactions using molecular mechanics calculations, plus the importance in the understanding of the mechanism of action and improvement of heterogenous catalysts. No index. Annotation copyrighted by Book News, Inc., Portland, OR
Author: Vincent Rotello Publisher: John Wiley & Sons ISBN: 0470384042 Category : Science Languages : en Pages : 492
Book Description
State-of-the-art techniques for tapping the vast potential of polymers The use of specific non-covalent interactions to control polymer structure and properties is a rapidly emerging field with applications in diverse disciplines. Molecular Recognition and Polymers covers the fundamental aspects and applications of molecular recognition—in the creation of novel polymeric materials for use in drug delivery, sensors, tissue engineering, molecular imprinting, and other areas. This reference begins by explaining the fundamentals of supramolecular polymers; it progresses to cover polymer formation and self-assembly with a wide variety of examples, and then includes discussions of biomolecular recognition using polymers. With chapters contributed by the foremost experts in their fields, this resource: Provides an integrated resource for supramolecular chemistry, polymer science, and interfacial science Covers advanced, state-of-the-art techniques used in the design and characterization of non-covalent interactions in polymers Illustrates how to tailor the properties of polymeric materials for various applications Stand-alone chapters address specific applications independently for easy reference. This is a premier resource for graduate students and researchers in polymer chemistry, supramolecular chemistry, materials science, and physical organic chemistry.
Author: Zerong Wang Publisher: John Wiley & Sons ISBN: 1118470451 Category : Science Languages : en Pages : 4542
Book Description
Winner of 2018 PROSE Award for MULTIVOLUME REFERENCE/SCIENCE This encyclopedia offers a comprehensive and easy reference to physical organic chemistry (POC) methodology and techniques. It puts POC, a classical and fundamental discipline of chemistry, into the context of modern and dynamic fields like biochemical processes, materials science, and molecular electronics. Covers basic terms and theories into organic reactions and mechanisms, molecular designs and syntheses, tools and experimental techniques, and applications and future directions Includes coverage of green chemistry and polymerization reactions Reviews different strategies for molecular design and synthesis of functional molecules Discusses computational methods, software packages, and more than 34 kinds of spectroscopies and techniques for studying structures and mechanisms Explores applications in areas from biology to materials science The Encyclopedia of Physical Organic Chemistry has won the 2018 PROSE Award for MULTIVOLUME REFERENCE/SCIENCE. The PROSE Awards recognize the best books, journals and digital content produced by professional and scholarly publishers. Submissions are reviewed by a panel of 18 judges that includes editors, academics, publishers and research librarians who evaluate each work for its contribution to professional and scholarly publishing. You can find out more at: proseawards.com Also available as an online edition for your library, for more details visit Wiley Online Library
Author: Publisher: Academic Press ISBN: 0124078311 Category : Science Languages : en Pages : 235
Book Description
Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid-state physics. Reviews the application of quantitative and mathematical methods toward understanding chemical problems Covers organic, organometallic, bioorganic, enzymes and materials topics
Author: Publisher: Elsevier ISBN: 0080471862 Category : Science Languages : en Pages : 325
Book Description
Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics.
Author: Mohammed Zourob Publisher: Springer Science & Business Media ISBN: 1441909192 Category : Technology & Engineering Languages : en Pages : 864
Book Description
Recognition receptors play a key role in the successful implementation of chemical and biosensors. Molecular recognition refers to non-covalent speci?c binding between molecules, one of which is typically a macromolecule or a molecular assembly, and the other is the target molecule (ligand or analyte). Biomolecular recognition is typically driven by many weak interactions such as hydrogen bo- ing, metal coordination, hydrophobic forces, van der Waals forces, pi-pi interactions and electrostatic interaction (due to permanent charges, dipoles, and quadrupoles) the polarization of charge distributions by the interaction partner leading to ind- tion and dispersion forces, and Pauli-exclusion-principle-derived inter-atomic repulsion, and a strong, “attractive” force arising largely from the entropy of the solvent and termed the hydrophobic effect. In recent years, there has been much progress in understanding the forces that drive the formation of such complexes, and how these forces are relate to the physical properties of the interacting molecules and their environment allows rational design of molecules and materials that interact in speci?c and desired ways. This book presents a signi?cant and up-to-date review of the various recognition elements, their immobilization, characterization techniques by a panel of dist- guished scientists. This work is a comprehensive approach to the recognition receptors area presenting a thorough knowledge of the subject and an effective integration of these receptors on sensor surfaces in order to appropriately convey the state-of the-art fundamentals and applications of the most innovative approaches.
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Author: A.D. Buckingham
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Author: Saul G. Cohen
Author: Stanley M. Roberts
Author: Vincent Rotello
Author: Zerong Wang
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Author: Mohammed Zourob