Molecular Biology of the Cell PDF Download

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Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0

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Author: Paula B. Andrade
Publisher: John Wiley & Sons
ISBN: 3527342052
Category : Medical
Languages : en
Pages : 348

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The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.

Author: Walter Wainio
Publisher: Elsevier
ISBN: 0323147607
Category : Science
Languages : en
Pages : 510

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The Mammalian Mitochondrial Respiratory Chain provides the vocabulary related to the mitochondrial respiratory chain in mammalian species. It explores the heterogeneous nature of mitochondria, the mammalian mitochondrial cytochromes, the concept of a respiratory chain for the oxidation of substrates, the cytochrome and non-cytochrome components of the chain, and the role of the respiratory chain in energy conservation. Organized into five chapters, this volume begins with an overview of the structure and composition of mitochondria in heart, liver, kidney, and brain before turning to the NADH oxidase system and its ability to generate one additional high-energy bond for every pair of electrons transferred compared to the succinate oxidase system. It also describes electron transfer in the respiratory chain and inhibitors of the respiratory chain such as antimycin A, along with differences in the pathways of electrons from succinate, choline, and NADH to oxygen as well as systems mediated by electron-transferring flavoprotein. The reader is also introduced to the processes involved in the fragmentation, extraction, and recombination of mitochondria; artificial electron acceptors such as phenazine methosulfate and artificial electron donors such as ascorbate and tetramethyl-p-phenylenediamine; and the role of flavoproteins, including flavin mononucleotide and flavin adenine dinucleotide, in electron transport. The book concludes with a chapter that explains how the oxidation-reductions of the respiratory chain release energy in discrete packets. Graduate students and beginning researchers in biology will find this book extremely helpful.

Author:
Publisher:
ISBN: 9781071608340
Category : Gene expression
Languages : en
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Author: Asha Kumari
Publisher: Elsevier
ISBN: 0443153493
Category : Science
Languages : en
Pages : 243

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Sweet Biochemistry: Remembering Structures, Cycles, and Pathways by Mnemonics, Second Edition makes biochemistry lively, interesting and memorable by connecting objects, images and stories to biochemistry concepts. Here, Dr. Asha Kumari has converted cycles and difficult pathways into very simple formula and short stories and images to help readers see things in complicated cycles and better visualize biochemistry. As biochemistry is evolving steadily, with new and impactful topics, this new edition has been fully updated to include mnemonics on timely topics in biochemistry such as DNA replication, RNA, transcription, translation, and CRISPR technology, as well as fundamentals of immunity. - Provides quick, indigenous formula, mnemonics, figures, poems and short stories to absorb key concepts in biochemistry - Presents original diagrams that are easy to recall - Features simplified tables for remembering distinguishing features - Updated to address evolving topics in basic and medical biochemistry, including DNA replication, RNA transcription and translation and immunity fundamentals

Author: Leonid Sazanov
Publisher: Springer Science & Business Media
ISBN: 9400741383
Category : Medical
Languages : en
Pages : 281

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The book contains chapters written by leaders in the research on the structure and function of respiratory complex I. It will provide a concise and authoritative summary of the current knowledge on complex I of respiratory chains. This enzyme is central to energy metabolism and is implicated in many human neurodegenerative diseases, as well as in aging. Until recently it was poorly understood on a structural level, and this book will provide a timely reference resource. Such a book was not published previously. The last time a minireview series on complex I were published was in 2001, and since then complex I field changed quite dramatically.

Author: Larry Engelking
Publisher: Academic Press
ISBN: 012391910X
Category : Technology & Engineering
Languages : en
Pages : 789

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Bridging the gap between basic and clinical science concepts, the Textbook of Veterinary Physiological Chemistry, Third Edition offers broad coverage of biochemical principles for students and practitioners of veterinary medicine. The only recent biochemistry book written specifically for the veterinary field, this text covers cellular-level concepts related to whole-body physiologic processes in a reader-friendly, approachable manner. Each chapter is written in a succinct and concise style that includes an overview summary section, numerous illustrations for best comprehension of the subject matter, targeted learning objectives, and end of the chapter study questions to assess understanding. With new illustrations and an instructor website with updated PowerPoint images, the Textbook of Veterinary Physiological Chemistry, Third Edition, proves useful to students and lecturers from diverse educational backgrounds. Sectional exams and case studies, new to this edition, extend the breadth and depth of learning resources. - Provides newly developed case studies that demonstrate practical application of concepts - Presents comprehensive sectional exams for self-assessment - Delivers instructor website with updated PowerPoint images and lecture slides to enhance teaching and learning - Employs a succinct communication style in support of quick comprehension

Author: Roberto Scatena
Publisher: Springer Science & Business Media
ISBN: 9400728697
Category : Medical
Languages : en
Pages : 459

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Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.

Author: Gerhard Heldmaier
Publisher: Springer Science & Business Media
ISBN: 9783540674108
Category : Medical
Languages : en
Pages : 568

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This book gives an up-to-date account of the current knowledge of cold adaptation in animals, including phenomena like hibernation, daily torpor, thermoregulation and thermogenesis, metabolic regulation, freeze tolerance, anaerobiosis, metabolic depression and related processes. For the next four years - until the 12th International Hibernation Symposium - it will serve as a state-of-the-art reference source for every scientist and graduate student working in these areas of physiology and zoology.

Author: S. Fleischer
Publisher: Springer Science & Business Media
ISBN: 1468424637
Category : Science
Languages : en
Pages : 354

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On February 14, 1977, a symposium entitled "The Molecular Biology of Membranes" was held in New Orleans in honor of Professor David E. Green, whose many contributions in mitochondrial structure and metabolism have influenced and guided research in this important area of biochemistry for many years. The symposium was attended by many former and present-day colleagues, friends, and interested scientists. The contents of this volume represent papers that were delivered at the symposium and other contributions from individuals who have been associates of Professor Green. We wish to thank Plenum Press for their help in making the symposium and publication of this book possible. Sidney Fleischer Youssef Hatefi David MacLennan Alexander Tzagoloff vii Contents Impressions of David E. Green by His Colleagues . . . . . . . . . . . . . . 1 Enzyme Institute Days 13 F. M. Huennekens Perspective for the Mitochondrion 17 David E. Green Chapter 1 Organization of Protein and Lipid Components in Membranes 29 Garret Vanderkooz Chapter 2 Structure of the Mitochondrion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 Robert A. Haworth and Douglas R. Hunter Chapter 3 Permeability of Membrane as a Factor Determining the Rate of Mitochondrial Respiration: Role of Ultrastructure . . . . . . . . . . . . . . 75 Jerzy Popinigis Chapter 4 Chemistry of Intrinsic Membrane Protein Complexes: Studies on Complex III and Cytochrome c Oxidase . . . . . . . . . . . . . . . . . . . . . . . 103 Roderick A. Capaldi ix x Contents Chapter 5 Reversible Mitochondrial ATPase as a Model for the Resolution of a 121 Membrane Complex A. E.