The journal of experimental biology. 196. Transporters PDF Download

Author: William Royal Harvey
Publisher:
ISBN: 9780948601477
Category :
Languages : en
Pages :

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Author:
Publisher:
ISBN:
Category : Biology
Languages : en
Pages : 312

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Author: Han van de Waterbeemd
Publisher: John Wiley & Sons
ISBN: 3527623876
Category : Medical
Languages : en
Pages : 649

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The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit from the key working knowledge of today's leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the factors governing drug bioavailability, complete with practical examples and real-life data. Part I focuses on in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and ionization. Part II discusses solubility and gastrointestinal absorption, while the third part is devoted to metabolism and excretory mechanisms. The much revised and expanded part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows how poor bioavailability may be improved by various approaches during the development process. No other publication offers the same level of treatment on this crucial topic in modern drug development.

Author: David Halton
Publisher: Cambridge University Press
ISBN: 9780521576376
Category : Medical
Languages : en
Pages : 248

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This collection of articles, edited by D. W. Halton, is the specially commissioned supplement to the journal Parasitology, volume 113.

Author:
Publisher:
ISBN:
Category : Biology
Languages : en
Pages : 472

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Author: Martha H. Stipanuk
Publisher: Elsevier Health Sciences
ISBN: 0323266959
Category : Medical
Languages : en
Pages : 968

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Covering advanced nutrition with a comprehensive, easy-to-understand approach, Biochemical, Physiological, and Molecular Aspects of Human Nutrition, 3rd Edition focuses on the biology of human nutrition at the molecular, cellular, tissue, and whole-body levels. It addresses nutrients by classification, and describes macronutrient function from digestion to metabolism. This edition includes the new MyPlate dietary guide and recommendations from the Dietary Guidelines for Americans 2010, plus coverage of the historical evolution of nutrition and information on a wide range of vitamins, minerals, and other food components. In Biochemical, Physiological, and Molecular Aspects of Human Nutrition, lead authors Martha H. Stipanuk and Marie A. Caudill are joined by a team of nutrition experts in providing clear, concise, coverage of advanced nutrition. 55 expert contributors provide the latest information on all areas of the nutrition sciences. Nutrition Insight boxes discuss hot topics and take a closer look at basic science and everyday nutrition. Clinical Correlation boxes show the connection between nutrition-related problems and their effects on normal metabolism. Food Sources boxes summarize and simplify data from the USDA National Nutrient Database on the amount and types of foods needed to reach the recommended daily allowances for vitamins and minerals. DRIs Across the Life Cycle boxes highlight the latest data from the Institute of Medicine on dietary reference intakes for vitamins and minerals, including coverage of infants, children, adult males and females, and pregnant and lactating women. Life Cycle Considerations boxes highlight nutritional processes or concepts applicable to individuals of various ages and in various stages of the life span. Thinking Critically sections within boxes and at the end of chapters help in applying scientific knowledge to "real-life" situations. Lists of common abbreviations provide an overview of each chapter's content at a glance. Comprehensive cross-referencing by chapters and illustrations is used throughout. Current references and recommended readings connect you to nutrition-related literature and provide additional tools for research. Coverage of the USDA's MyPlate dietary guide reflects today's new approach to diet and nutrition. Recommendations outlined in the Dietary Guidelines for Americans 2010 are incorporated throughout the book. Updated format features more subheadings, tables, and bullets, making it easier to learn and recall key points. Updates of key chapters and boxes reflect significant changes within the fields of nutrition, biology, molecular biology, and chemistry. NEW illustrations simplify complex biochemical, physiological, and molecular processes and concepts.

Author: George A. Gerencser
Publisher: Springer Science & Business Media
ISBN: 1603272291
Category : Science
Languages : en
Pages : 493

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Biological cell membranes regulate the transfer of matter and information between the intracellular and extracellular compartments as basic survival and maintenance functions for an organism. This volume contains a series of reviews that are c- cerned with how epithelial plasma membranes regulate the transport of solutes between the intracellular and extracellular compartments of a cell. This book is also an attempt to analyze the molecular basis for the movement of various solutes across an epithelial cell membrane. This volume is devoted to a diversity of epithelial transport mechanisms in rep- sentative cell membranes of a variety of living things. The ?rst section of the book (Chapters 1–6) focuses on mechanisms of solute transport in epithelia of inver- brates. The last section which comprises ten chapters (Chapters 7–16) deals with solute transporters in epithelial cell membranes of vertebrates. It is hoped that with this particular ordering the reader can glean a telescopic view of the evolutionary history of the various epithelial solute transporters.

Author: Asim K. Duttaroy
Publisher: CRC Press
ISBN: 1482254298
Category : Medical
Languages : en
Pages : 432

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Human Placental Trophoblasts: Impact of Maternal Nutrition explores the vital roles of trophoblasts play in fetal growth and pregnancy, giving you new insight into the modulation of placental trophoblast functions by nutrients. It also reviews the role of fatty acids, folic acids, and specific vitamins in this aspect. The book highlights the critic

Author: Colin R Martin
Publisher: Academic Press
ISBN: 0128179872
Category : Psychology
Languages : en
Pages : 686

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Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. In addition, the book examines in vitro and in vivo modeling of development with stem cells and model systems. Provides the most comprehensive coverage of a broad range of topics relating to the neuroscience of development Features sections on the genetics of developmental conditions and accompanying behavior Contains an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding in each chapter Focuses on neurodevelopmental disorders and environmental factors that influence neural development Includes more than 500 illustrations and tables

Author:
Publisher: Elsevier
ISBN: 0080561799
Category : Technology & Engineering
Languages : en
Pages : 495

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Book Description
Advances in Botanical Research is a multi-volume publication that brings together reviews by recognized experts on subjects of importance to those involved in botanical research. For more than thirty years, Advances in Botanical Research has earned a reputation for excellence in the field. For those working on plant pathology, Advances in Plant Pathology has also carved a niche in the plant sciences during its decade of publication.Academic Press has merged Advances in Plant Pathology into Advances in Botanical Research. The plant science community will find that the merger of these two serials will provide one comprehensive resource for the field. To ensure complete coverage, John Andrews and Inez Tommerup, the editors of Advances in Plant Pathology, have joined the editorial board of the new series, which will include equal coverage of plant pathology and botany in both thematic and mixed volumes. The first few volumes of the new series will be slanted toward botany or plant pathology; however, future eclectic volumes will be fully integrated.The resulting synergy of these two serials greatly benefits the plant science community by providing a more comprehensive resource under one roof. The joint aim is to continue to include the very best articles, thereby maintaining the status of a high impact factor review series.