The Innate Immune Response to Noninfectious Stressors PDF Download

Author: Massimo Amadori
Publisher: Academic Press
ISBN: 0128019743
Category : Medical
Languages : en
Pages : 278

View

Book Description
The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans Covers the crucial issue of the immune response to endocrine disruptors Includes immunological parameters as reporter system of environmental adaptation Provides many illustrative examples to foster reader understanding

Author: Alexander Choukèr
Publisher: Springer Nature
ISBN: 3030169960
Category : Medical
Languages : en
Pages : 756

View

Book Description
This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author: Ronald Glaser
Publisher: Academic Press
ISBN: 1483295125
Category : Medical
Languages : en
Pages : 436

View

Book Description
In 1964, George Solomon coined the term psychoneuroimmunology. In the intervening 30 years, this term has emerged into a dynamic field of study which investigates the unique interactions between the nervous, endocrine, and immune systems. The Handbook of Human Stress and Immunity is a comprehensive reference for this dynamic new field. Focusing on how stressors impact the central nervous system and the resulting changes in immune responses, the Handbook is the first to describehow stress specifically affects human immune systems. It discusses how stress generally makes people more susceptible to infection, how personal support systems can counteract the physiological effects of stress, and how stress, or lack of stress, affects the aging process. Chapters are authored by the leading names in the field and cover such diseases as autoimmune disease, viral pathogenesis, herpes, HIV, and AIDS.

Author: G. Hartmann
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318023477
Category : Science
Languages : en
Pages : 140

View

Book Description
Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art‘ in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.

Author: Inna B. Mertsalova
Publisher: FriesenPress
ISBN: 1525501860
Category : Self-Help
Languages : en
Pages : 202

View

Book Description
More Than a Book About Stress – A Self-Help Tool That Gathers All You Need to Know to Stay Healthy In recent years, we have gained increasing knowledge of the roles stress and stress hormones play in our health. It is amazing how the presentation of a stressor—whether in one event or a series of events—might involve us in appraising the environmental challenge and lead us to the “fight-or-flight” response on a physiological level. The idea that stress has only harmful effects does not draw a full picture of its role in our health and well-being. It is scientifically proven that stress and stress hormones not only have a negative impact on our bodies, but they also have potentially beneficial properties, aimed at mobilizing our immune system for fighting immunologic confrontations. How does this work? In Stress and Immunity, Dr. Inna B. Mertsalova illustrates how our immune system functions under exposure to stress. Understanding these processes can help us cope with stress and stay healthy. The book also includes a test to check how you cope with stress and the information about sleep habits, physical activities, and nutrition that are necessary for reducing your stress level. This book is a valuable empirically proven source of information about the bi-directional effects of stress on our immune system. This book is written for everyone who wants to understand how stress modifies our body causing illness. Also, this volume has a great potential as a supplemental reading material for graduate students in the broad range of medical education.

Author: Bruce S. Rabin
Publisher: Wiley-Liss
ISBN:
Category : Medical
Languages : en
Pages : 368

View

Book Description
Written by a renowned figure in the field of immunology and compiling a wealth of scientific information, Stress, Immune Function, and Health: The Connection looks at the long-term effects of stress on human health from a psychoneuroimmunological approach. The recent changes in dietary modifications, clinical applications, and evolution in the field of immunology have created the need for a book which addresses the growing awareness of health benefits that can be achieved by buffering the effects of stress on the immune system. Emphasizing the importance of the interaction among the mind, the body, and physical health, this reference includes important developmental procedures that can be used to resist stress on the immune system. By examining components of the immune system, along with the effects of psychological stress and the capacity for hormonal response, author Bruce Rabin demonstrates, in a concise, accessible manner, the ability of an individual's immune system to alter susceptibility to immune-mediated diseases. In addition, the book examines several key issues in this rapidly expanding field, including: * Information and examples that illustrate how distinct areas of the brain that perceive the presence of a stressor are able to communicate with the cells of the immune system * The correlation between stress-related changes in health practices and stressor-induced risks of disease development * The effect on the immune system due to stress from an increased concentration of neuropeptides and hormones * Behaviors and beliefs that can reduce the harmful effects of stress on the immune system by interfering with the stress-responsive areas of the brain * The issue of stress during pregnancy and the early period of development on behaviors and immune functions in children An authoritative guide for all researchers and students in the fields of immunology, neuroscience, and psychology, Stress, Immune Function, and Health: The Connection is also an essential reference for physicians and nurses concerned with stress and immune-related diseases.

Author: Nicholas P. Plotnikoff
Publisher: CRC Press
ISBN: 9780849388453
Category : Medical
Languages : en
Pages : 572

View

Book Description
Stress and Immunity introduces and updates the status of research on stress and immunity. Clinical aspects of stress and immunity are presented in the first 17 chapters and include discussions regarding the influence of depression disorders on immune functions and stress interrelationships with cancer, AIDS, Chronic Fatigue Syndrome, and Herpes Simplex infections. There is also a review of physical exercise and immunity. The second half of the book is devoted to discussions regarding basic research being conducted in the field of stress and immunity. This includes discussions on the interrelationships of the central nervous system and the immune system and research on stress hormones (e.g., enkephalins, endorphins) as they interrelate with the immune system. In addition, animal models for the study of stress and immunity are discussed. Psychiatrists, neurologists, psychologists, clinical psychologists, internists, immunologists, and researchers in psychosomatic disorders should consider this an essential reference volume.

Author: Julie R. Hoye
Publisher:
ISBN: 9780438931985
Category :
Languages : en
Pages : 84

View

Book Description
Early life stress is associated with numerous diseases in adulthood that may be caused by dysregulation of pro-inflammatory and anti-inflammatory immune responses. The current study investigated contributions of early life stress, acute stress, and parental nurturance on innate immune functioning after the administration of the influenza vaccine. The influenza vaccine produced an elevation in CRP and IL-10 levels in children aged 8 to 11 years, but no significant elevation in IL-6 levels was observed. Early life stress did not significantly affect the trajectory of any cytokine after the influenza vaccine. Likewise, acute stress, or daily hassles, did not significantly affect cytokine production following the vaccine among children regardless of exposure to early life stress. In addition, parental nurturance did not significantly alter the innate immune system response following the influenza vaccine for either risk group. Among children who experienced high levels of early life stress, cytokine trajectory after receiving the influenza vaccine did not differ significantly between children who received an attachment based intervention, Attachment and Biobehavioral Catch-Up, and those who received a control intervention.

Author: R. Ahmed
Publisher: Wiley-Blackwell
ISBN:
Category : Medical
Languages : en
Pages : 754

View

Book Description
Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309173183
Category : Medical
Languages : en
Pages : 722

View

Book Description
Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.