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Author: Rogier Willem Sanders Publisher: Amsterdam University Press ISBN: 9789053566671 Category : Medical Languages : en Pages : 342
Book Description
The need for a vaccine against HIV is obvious, but the development of an effective vaccine has met with frustrations. The HIV envelope glycoproteins, residing in the viral membrane, are the sole viral proteins exposed on the outside of virus particles and.
Author: Rogier Willem Sanders Publisher: Amsterdam University Press ISBN: 9789053566671 Category : Medical Languages : en Pages : 342
Book Description
The need for a vaccine against HIV is obvious, but the development of an effective vaccine has met with frustrations. The HIV envelope glycoproteins, residing in the viral membrane, are the sole viral proteins exposed on the outside of virus particles and.
Author: Ralph Pantophlet Publisher: Springer Science & Business Media ISBN: 1461488729 Category : Medical Languages : en Pages : 226
Book Description
Glycosylation is a common and extremely important modification in biological molecules, particularly of proteins. HIV Glycans in Infection and Immunity provides an overview of the roles of glycans in the transmission/infection, antigenicity, and immunogenicity of HIV and the HIV envelope glycoprotein. It explores recent advances in the understanding of the impact of HIV glycans in infection and their promise for immunological and therapeutic intervention. Novel collaborations between glycobiologists and immunologists in recent years have led to key advances in the understanding of HIV glycans. These cross-disciplinary endeavors, their achievements and their impact on the field are all addressed, herein.
Author: Publisher: ISBN: Category : Languages : en Pages :
Book Description
The HIV-1 envelope glycoproteins gp120 and gp41 mediate binding and fusion of the virus to target cells. The envelope glycoproteins are exposed on the surface of the virus as trimeric spikes and are the major targets for neutralizing antibodies. The design of envelope glycoprotein-based subunit vaccines has been frustrated by many viral immune escape mechanisms. Trimeric envelope glycoprotein formulations hold promise to overcome limitations of monomeric envelope glycoproteins as immunogens. The generation of native, trimeric envelope glycoprotein complexes, however, remains a major challenge. Here, solid-phase proteoliposomes containing native, trimeric HIV-1 envelope glycoprotein complexes that mimic the trimeric complex as it is found on the viral surface have been designed. In a comparative immunogenicity study, these proteoliposomes were shown to better elicit broadly neutralizing antibodies than gp120. A second trimeric envelope glycoprotein formulation, soluble YU2 gp140-GCN4 constructs, were also shown to better elicit broadly neutralizing antibodies in rabbits, extending a previous study in mice. These data support the hypothesis that trimeric envelope glycoprotein formulations are an advance over gp120-based immunogens. To date, only four broadly neutralizing antibodies against the HIV-1 envelope glycoproteins have been identified. Here, three novel Fab antibody fragments binding to the CD4 binding site of gp120 have been identified from phage-displayed antibody libraries with proteoliposomes. These Fab antibodies display some breadth and potency in neutralizing HIV-1. Comparison of the neutralizing activity of Fab antibodies and whole antibodies directed to the CD4 binding site suggests that these Fab antibodies may significantly gain neutralizing potency as whole antibodies. Many HIV-1 immune escape mechanisms complicate the elicitation of broadly neutralizing antibodies. Core gp120 envelope glycoproteins derived from primary isolate viruses were found t.
Author: Joseph Bentz Publisher: CRC Press ISBN: 9780849356063 Category : Science Languages : en Pages : 548
Book Description
Viral Fusion Mechanisms presents the first comprehensive review on this exciting topic. The book focuses on molecular mechanisms rather than phenomonology and examines a wide range of viruses, including influenza, HIV, Sendai, SFV, Vaccinia, VSV, and RSV. Recent theoretical work on dissecting protein-mediated membrane fusion is discussed, and the most promising new technologies for elucidating mechanisms are highlighted. Viral Fusion Mechanisms is an essential reference for biophysicists, cell biologists, colloid chemists, immunologists, microbiologists, molecular biologists, and virologists.
Author: Publisher: Academic Press ISBN: 0128033274 Category : Science Languages : en Pages : 393
Book Description
Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains. Written by leading experts Contains original material, both textual and illustrative, that should become a very relevant reference material The material is presented in a very comprehensive manner Both researchers in the field and general readers should find relevant and up-to-date information
Author: Rogier Willem Sanders
Author: Rogier Willem Sanders
Author: Thomas J. Hope
Author: Carol D. Weiss
Author: Shiow-Her Chiou
Author: Daniel Sung Nam
Author: Ralph Pantophlet
Author: 
Author: Joseph Bentz
Author: Ngoc Thi Phan
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