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Author: Richard Gordon Publisher: World Scientific ISBN: 9789810222680 Category : Science Languages : en Pages : 936
Book Description
Over the past few decades numerous scientists have called for a unification of the fields of embryo development, genetics, and evolution. Each field has glaring holes in its ability to explain the fundamental phenomena of life. In this book, the author shows how the phenomenon of cell differentiation, considered in its temporal and spatial aspects during embryogenesis, provides a starting point for a unified theory of multicellular organisms (plants, fungi and animals), including their evolution and genetics. This unification is based on the recent discovery of differentiation waves by the author and his colleagues, described in the appendices, and illustrated by a flip movie prepared by a medical artist. To help the reader through the many fields covered, a glossary is included.This book will be of great value to the researcher and practicing doctors/scientists alike. The research students will receive an in-depth tutorial on the topics covered. The seasoned researcher will appreciate the applications and the gold mine of other possibilities for novel research topics.
Author: Richard Gordon Publisher: World Scientific ISBN: 9789810222680 Category : Science Languages : en Pages : 936
Book Description
Over the past few decades numerous scientists have called for a unification of the fields of embryo development, genetics, and evolution. Each field has glaring holes in its ability to explain the fundamental phenomena of life. In this book, the author shows how the phenomenon of cell differentiation, considered in its temporal and spatial aspects during embryogenesis, provides a starting point for a unified theory of multicellular organisms (plants, fungi and animals), including their evolution and genetics. This unification is based on the recent discovery of differentiation waves by the author and his colleagues, described in the appendices, and illustrated by a flip movie prepared by a medical artist. To help the reader through the many fields covered, a glossary is included.This book will be of great value to the researcher and practicing doctors/scientists alike. The research students will receive an in-depth tutorial on the topics covered. The seasoned researcher will appreciate the applications and the gold mine of other possibilities for novel research topics.
Author: Matthew He Publisher: World Scientific ISBN: 9814481017 Category : Science Languages : en Pages : 633
Book Description
This unique volume presents major developments and trends in bioinformatics and its applications. Comprising high-quality scientific research papers and state-of-the-art survey articles, the book has been divided into five main sections: Microarray Analysis and Regulatory Networks; Machine Learning and Statistical Analysis; Biomolecular Sequence and Structure Analysis; Symmetry in Sequences; and Signal Processing, Image Processing and Visualization. The results of these investigations help the practicing biologist in many ways: in identifying unknown connections, in narrowing down possibilities for a search, in suggesting new hypotheses, designing new experiments, validating existing models or proposing new ones. It is an essential source of reference for researchers and graduate students in bioinformatics, computer science, mathematics, statistics, and biological sciences based on select papers from the “The International Conference on Bioinformatics and Its Application” (ICBA), held December 16-19, 2004 in Fort Lauderdale, Florida, USA.
Author: Andrej Yu Yakovlev Publisher: World Scientific ISBN: 9810218311 Category : Medical Languages : en Pages : 287
Book Description
This research monograph discusses newly developed mathematical models and methods that provide biologically meaningful inferences from data on cancer latency produced by follow-up and discrete surveillance studies. Methods for designing optimal strategies of cancer surveillance are systematically presented for the first time in this book. It offers new approaches to the stochastic description of tumor latency, employs biologically-based models for making statistical inference from data on tumor recurrence and also discusses methods of statistical analysis of data resulting from discrete surveillance strategies. It also offers insight into the role of prognostic factors based on the interpretation of their effects in terms of parameters endowed with biological meaning, as well as methods for designing optimal schedules of cancer screening and surveillance. Last but not least, it discusses survival models allowing for cure rates and the choice of optimal treatment based on covariate information, and presents numerous examples of real data analysis.
Author: P Combe Publisher: World Scientific ISBN: 981449514X Category : Computers Languages : en Pages : 228
Book Description
Recent developments in the neurosciences have considerably modified our knowledge of both the operating modes of neurons and information processing in the cortex. Multi-unit recordings have enabled temporal correlations to be detected, within temporal windows of the order of 1ms. Oscillations corresponding to a quasi-periodic spike-giving, synchronized over several visual cortical areas, have been observed in anaesthesized cats and monkeys. Recent studies have also focused on the role played by the dendritic arborization.These developments have led to considerable interest in a coding scheme which relies on precise spatio-temporal patterns from both the theoretical and experimental points of view. This prompts us to look into new models for information processing which will proceed, for example, from a synchronous detection of correlated spike giving, and is particularly robust against noise. Such models could bring about original technical applications for information processing and control.Further developments in this field may be of major importance for our understanding of the basic mechanisms of perception and cognition. They could also lead to new concepts in applications directed towards artificial perception and pattern recognition. Up to now, artificial systems for pattern recognition are far from reaching the standards of human vision. Systems based on a temporal coding by spikes may now be expected to bring about major improvements in this field.This book covers the lectures delivered at a summer school on neuronal information processing. It includes information on all the above-mentioned developments, and also provides the reader with the state-of-the-art in every relevant field, including the neurosciences, physics, mathematics, and information and control theory.
Author: Natalie K Gordon Publisher: World Scientific ISBN: 9814740691 Category : Science Languages : en Pages : 784
Book Description
The greatest mystery of life is how a single fertilized egg develops into a fully functioning, sometimes conscious multicellular organism. Embryogenesis Explained offers a new theory of how embryos build themselves, and combines simple physics with the most recent biochemical and genetic breakthroughs, based on the authors' prediction and then discovery of differentiation waves. They explain their ideas in a form accessible to the lay person and a broad spectrum of scientists and engineers. The diverse subjects of development, genetics and evolution, and their physics, are brought together to explain this major, previously unanswered scientific question of our time.As a follow up on The Hierarchical Genome, this book is a shorter but conceptually expanded work for the reader who is interested in science. It is useful as a starting point for the curious layman or the scientist or professional encountering the problem of embryogenesis without the formal biology background. There is also material useful for the seasoned biologist caught up in the new rush of information about the role of mechanics in developmental biology and cellular level mechanics in medicine.
Author: Joseph Seckbach Publisher: John Wiley & Sons ISBN: 1119488192 Category : Science Languages : en Pages : 448
Book Description
DIATOM MORPHOGENESIS A unique book presenting the range of silica structures formed by diatoms, theories and hypotheses of how they are made, and applications to nanotechnology by use or imitation of diatom morphogenesis. There are up to 200,000 species of diatoms, each species of these algal cells bearing an ornate, amorphous silica glass shell. The silica is structured at 7 orders of magnitude size range and is thus the most complex multiscalar solid structure known. Recent research is beginning to unravel how a single cell marshals chemical, physical, biochemical, genetic, and cytoskeletal processes to produce these single-cell marvels. The field of diatom nanotechnology is advancing as this understanding matures. Diatoms have been actively studied over the recent 10-20 years with various modern equipment, experimental and computer simulation approaches, including molecular biology, fluorescence-based methods, electron, confocal, and AFM microscopy. This has resulted in a huge amount of information but the key stages of their silica morphogenesis are still not clear. This is the time to reconsider and consolidate the work performed so far and to understand how we can go ahead. The main objective of this book is to describe the actual situation in the science of diatom morphogenesis, to specify the most important unresolved questions, and to present the corresponding hypotheses. The following areas are discussed: A tutorial chapter, with a glossary for newcomers to the field, who are often from outside of biology, let alone phycology; Diatom Morphogenesis: general issues, including symmetry and size issues; Diatom Morphogenesis: simulation, including analytical and numerical methods for description of the diatom valve shape and pore structure; Diatom Morphogenesis: physiology, biochemistry, and applications, including the relationship between taxonomy and physiology, biosilicification hypotheses, and ideas about applications of diatoms. Audience Researchers, scientists, and graduate students in the fields of phycology, general biology, marine sciences, the chemistry of silica, materials science, and ecology.
Author: Alexei A. Sharov Publisher: John Wiley & Sons ISBN: 1119865093 Category : Science Languages : en Pages : 516
Book Description
Pathways to the Origin and Evolition of Meanings in the Universe The book explains why meaning is a part of the universe populated by life, and how organisms generate meanings and then use them for creative transformation of the environment and themselves. This book focuses on interdisciplinary research at the intersection of biology, semiotics, philosophy, ethology, information theory, and the theory of evolution. Such a broad approach provides a rich context for the study of organisms and other semiotic agents in their environments. This methodology can be applied to robotics and artificial intelligence for developing robust, adaptable learning devices. In this book, leading interdisciplinary scholars reveal their vision on how to integrate natural sciences with semiotics, a theory of meaning-making and signification. Developments in biology indicate that the capacity to create and understand signs is not limited to humans or vertebrate animals, but exists in all living organisms - the fact that inspired the integration of biology and semiotics into biosemiotics. The authors discuss the nature of semiotic agents (organisms and other autonomous goal-directed units), meaning, signs, information, memory, evolution, and consciousness. Also discussed are issues including the origin of life, potential meaning and its actualization, top-down causality in physics and biology, capacity of organisms to encode their functions, the strategy of organisms to combine homeostasis with direct adaptation to new life-cycle phases or new environments, multi-level memory systems, increase of freedom via enabling constraints, creative modeling in evolution and learning, communication in animals and humans, the origin and function of language, and the distribution and transfer of life in space. This is the first book on biosemiotics in its global conceptual and spatial scope. Biosemiotics is presented using the language of natural sciences, which supports the scientific grounding of semiotic terms. Finally, the cosmic dimension of life and meaning-making leads to a reconsideration of ethical principles and ecological mentality here on earth and in space exploration. Audience Theoretical biologists, ethologists, astrobiologists, ecologists, evolutionary biologists, philosophers, phenomenologists, semioticians, biosemioticians, molecular biologists, linguists, system scientists and engineers.
Author: Richard Gordon Publisher: John Wiley & Sons ISBN: 1119901022 Category : Science Languages : en Pages : 1268
Book Description
This book surveys the models for the origin of life and presents a new model starting with shaped droplets and ending with life as polygonal Archaea; it collects the most published micrographs of Archaea (discovered only in 1977), which support this conclusion, and thus provides the first visual survey of Archaea. Origin of Life via Archaea’s purpose is to add a new hypothesis on what are called “shaped droplets”, as the starting point, for flat, polygonal Archaea, supporting the Vesicles First hypothesis. The book contains over 6000 distinct references and micrographs of 440 extant species of Archaea, 41% of which exhibit polygonal phenotypes. It surveys the intellectual battleground of the many ideas of the origin of life on earth, chemical equilibrium, autocatalysis, and biotic polymers. This book contains 17 chapters, some coauthored, on a wide range of topics on the origin of life, including Archaea’s origin, patterns, and species. It shows how various aspects of the origin of life may have occurred at chemical equilibrium, not requiring an energy source, contrary to the general assumption. For the reader’s value, its compendium of Archaea micrographs might also serve many other interesting questions about Archaea. One chapter presents a theory for the shape of flat, polygonal Archaea in terms of the energetics at the surface, edges and corners of the S-layer. Another shows how membrane peptides may have originated. The book also includes a large table of most extant Archaea, that is searchable in the electronic version. It ends with a chapter on problems needing further research. Audience This book will be used by astrobiologists, origin of life biologists, physicists of small systems, geologists, biochemists, theoretical and vesicle chemists.
Author: Joseph Seckbach Publisher: John Wiley & Sons ISBN: 1119640938 Category : Science Languages : en Pages : 354
Book Description
An in-depth view of the panspermia hypothesis examined against the latest knowledge of planetary formation and related processes. Panspermia is the concept that life can be passively transported through space on various bodies and seed, habitable planets and moons, which we are beginning to learn may exist in large numbers. It is an old idea, but not popular with those who prefer that life on Earth started on Earth, an alternative, also unproven hypothesis. This book updates the concept of panspermia in the light of new evidence on planet formation, molecular clouds, solar system motions, supernovae ejection mechanisms, etc. Thus, it is to be a book about newly understood prospects for the movement of life through space. The novel approach presented in this book gives new insights into the panspermia theory and its connection with planetary formation and the evolution of galaxies. This offers a good starting point for future research proposals about exolife and a better perspective for empirical scrutiny of panspermia theory. Also, the key to understanding life in the universe is to understand that the planetary formation process is convolved with the evolution of stellar systems in their galactic environment. The book provides the synthesis of all these elements and gives the readers an up-to-date insight on how panspermia might fit into the big picture. Audience Given the intrinsic interdisciplinary nature of the panspermia hypothesis the book will have a wide audience across various scientific disciplines covering astronomy, biology, physics and chemistry. Apart from scientists, the book will appeal to engineers who are involved in planning and realization of future space missions.
Author: Janice L. Pappas Publisher: John Wiley & Sons ISBN: 1119750431 Category : Science Languages : en Pages : 484
Book Description
THE MATHEMATICAL BIOLOGY OF DIATOMS This book contains unique, advanced applications using mathematics, algorithmic techniques, geometric analysis, and other computational methods in diatom research. Historically, diatom research has centered on taxonomy and systematics. While these topics are of the utmost importance, other aspects of this important group of unicells have been increasingly explored in the biological sciences. While mathematical applications are still rare, they are starting take hold and provide an extensive avenue of new diatom research, including applications in multidisciplinary fields. The work contained in this volume is an eclectic mix of analytical studies on diatoms. Mathematical treatment of the various biological disciplines covered in this book range from implicit, but succinct studies to more elaborate detailed computational studies. Topics include growth models, nanostructure, nanoengineering, cell growth, araphid diatoms, valve ontogeny, diatom metabolism, diatom motility, synchronization, diatom kinematics, photonics, biogenic sensors, photochemistry, diatom light response, colony growth, siliceous unicells, algal kinetics, diatom structure, diatom imaging, functional morphology, geometric structure, biomineralization, high-resolution imaging, non-destructive imaging, and 3D structure. This wide-ranging volume provides an introductory as well as an advanced treatment of recent interests in diatom research. The mathematical research in this volume may be applicable to studies of other unicells, biomechanics, biological processes, physio-chemical analyses, or nanoscience.
Author: Richard Gordon
Author: Richard Gordon
Author: Matthew He
Author: Andrej Yu Yakovlev
Author: P Combe
Author: Natalie K Gordon
Author: Joseph Seckbach
Author: Alexei A. Sharov
Author: Richard Gordon
Author: Joseph Seckbach
Author: Janice L. Pappas