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The Hayflick Limit

The Hayflick Limit PDF Author: Matthew Tierney
Publisher: Coach House Books
ISBN: 1770560912
Category : Poetry
Languages : en
Pages : 89

Book Description
To be human is to cope with knowing. In the early 1960s, Leonard Hayflick determined that healthy cells can divide only a finite number of times. Known as the Hayflick Limit, it sets an unsurpassable lifespan for our species at just over 120 years. Shifting focus between the limits of the microscope and the limits of the telescope, Matthew Tierney gives voice to a range of characters who scrape out meaning in a carnivalesque universe, one that has birthed black holes and Warner Bros. cartoons, murky market economies, murkier quantum laws, Vincent Price, Molotov cocktails, seedless grapes, Area 51 and competing Theories of Everything.

The Hayflick Limit

The Hayflick Limit PDF Author: Matthew Tierney
Publisher: Coach House Books
ISBN: 1770560912
Category : Poetry
Languages : en
Pages : 89

Book Description
To be human is to cope with knowing. In the early 1960s, Leonard Hayflick determined that healthy cells can divide only a finite number of times. Known as the Hayflick Limit, it sets an unsurpassable lifespan for our species at just over 120 years. Shifting focus between the limits of the microscope and the limits of the telescope, Matthew Tierney gives voice to a range of characters who scrape out meaning in a carnivalesque universe, one that has birthed black holes and Warner Bros. cartoons, murky market economies, murkier quantum laws, Vincent Price, Molotov cocktails, seedless grapes, Area 51 and competing Theories of Everything.

How and why We Age

How and why We Age PDF Author: Leonard Hayflick
Publisher:
ISBN: 9780345401557
Category : Aging
Languages : en
Pages : 0

Book Description
"How long can humans live? Is immortality possible? Just what is the aging process? The aging and inevitable death of the human body have inspired more myths and outrageous quackery than anything else subject to scientific inquiry. . . . Now comes a most fascinating book, insightful and scholarly, to provide what answers have emerged so far." --San Francisco Chronicle Here, at last, preeminent cell biologist Leonard Hayflick presents the truth about human aging. Based on more than thirty years of pioneering research in the field, How and Why We Age explores not only how our major biological systems change as we grow older, but also examines the intangible alterations in our modes of thinking and feeling, our moods and sexual desires, our personality traits and our memories. With the immediacy of the latest scientific discoveries, Dr. Hayflick explains how aging affects every part of the body, and dispels many of the most persistent aging myths, to show that: * Hearts do not naturally get weaker with age. * Regular exercise and a low-fat diet won't slow aging. * Curing cancer would only add two years to the average sixty-five-year-old American life. Curing heart disease, however would add fourteen years. * Only five percent of people over the age of sixty-five are in nursing homes * No human has lived--or probably can live--past 120 years. Gracefully written, clearly organized, and packed with essential facts and statistics, How and Why We Age is a landmark study of the aging process for readers of all ages. "Written in clear, nontechnical language, it is an excellent introduction to the scientific and demographic literature on this multifacetedsubject." --Nature

The Vaccine Race

The Vaccine Race PDF Author: Meredith Wadman
Publisher: Penguin
ISBN: 0143111310
Category : Science
Languages : en
Pages : 466

Book Description
"A real jewel of science history...brims with suspense and now-forgotten catastrophe and intrigue...Wadman’s smooth prose calmly spins a surpassingly complicated story into a real tour de force."—The New York Times “Riveting . . . [The Vaccine Race] invites comparison with Rebecca Skloot's 2007 The Immortal Life of Henrietta Lacks.”—Nature The epic and controversial story of a major breakthrough in cell biology that led to the conquest of rubella and other devastating diseases. Until the late 1960s, tens of thousands of American children suffered crippling birth defects if their mothers had been exposed to rubella, popularly known as German measles, while pregnant; there was no vaccine and little understanding of how the disease devastated fetuses. In June 1962, a young biologist in Philadelphia, using tissue extracted from an aborted fetus from Sweden, produced safe, clean cells that allowed the creation of vaccines against rubella and other common childhood diseases. Two years later, in the midst of a devastating German measles epidemic, his colleague developed the vaccine that would one day wipe out homegrown rubella. The rubella vaccine and others made with those fetal cells have protected more than 150 million people in the United States, the vast majority of them preschoolers. The new cells and the method of making them also led to vaccines that have protected billions of people around the world from polio, rabies, chicken pox, measles, hepatitis A, shingles and adenovirus. Meredith Wadman’s masterful account recovers not only the science of this urgent race, but also the political roadblocks that nearly stopped the scientists. She describes the terrible dilemmas of pregnant women exposed to German measles and recounts testing on infants, prisoners, orphans, and the intellectually disabled, which was common in the era. These events take place at the dawn of the battle over using human fetal tissue in research, during the arrival of big commerce in campus labs, and as huge changes take place in the laws and practices governing who “owns” research cells and the profits made from biological inventions. It is also the story of yet one more unrecognized woman whose cells have been used to save countless lives. With another frightening virus--measles--on the rise today, no medical story could have more human drama, impact, or urgency than The Vaccine Race.

Intrinsic mutagenesis

Intrinsic mutagenesis PDF Author: Burnet MacFarlane
Publisher: Springer Science & Business Media
ISBN: 9401166064
Category : Medical
Languages : en
Pages : 245

Book Description
This book is something which almost accidentally has developed very differently from how it was initially planned. The intention was to elaborate the part played by the immune system in ageing with the role of the thymus as central theme. It was to be essentially an expansion of a lecture I gave in 1970 and would inevitably have been concerned with much the same material as Walford's book, The Immunologic Theory of Aging, though from a different slant. What changed its character arose from a series of attempts to find logical connection between two findings that most gerontologists regard as axiomatic: that the lifespan of a mammal is genetically determined, and that the actual process of ageing is an accumulation of genetic error, of somatic mutations. It is possible that the connection is so indirect, circuitous and multiform that generations of detailed and unattractive research will be needed to elucidate it, or, more likely, the whole matter discarded as a non-problem. But a more inspiring approach does seem possible. The working hypothesis, which halfway through its writing became the new central theme of the book, arose when I was a member of a committee appointed by the Australian Academy of Science at the request of the Australian Government to advise on the danger from French nuclear tests in the South Pacific.

The Immortal Life of Henrietta Lacks

The Immortal Life of Henrietta Lacks PDF Author: Rebecca Skloot
Publisher: Crown
ISBN: 0307589382
Category : Science
Languages : en
Pages : 386

Book Description
#1 NEW YORK TIMES BESTSELLER • “The story of modern medicine and bioethics—and, indeed, race relations—is refracted beautifully, and movingly.”—Entertainment Weekly NOW A MAJOR MOTION PICTURE FROM HBO® STARRING OPRAH WINFREY AND ROSE BYRNE • ONE OF THE “MOST INFLUENTIAL” (CNN), “DEFINING” (LITHUB), AND “BEST” (THE PHILADELPHIA INQUIRER) BOOKS OF THE DECADE • ONE OF ESSENCE’S 50 MOST IMPACTFUL BLACK BOOKS OF THE PAST 50 YEARS • WINNER OF THE CHICAGO TRIBUNE HEARTLAND PRIZE FOR NONFICTION NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • Entertainment Weekly • O: The Oprah Magazine • NPR • Financial Times • New York • Independent (U.K.) • Times (U.K.) • Publishers Weekly • Library Journal • Kirkus Reviews • Booklist • Globe and Mail Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than sixty years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave. Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of. Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah. Deborah was consumed with questions: Had scientists cloned her mother? Had they killed her to harvest her cells? And if her mother was so important to medicine, why couldn’t her children afford health insurance? Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

The Hayflick Limit

The Hayflick Limit PDF Author: Kenneth Linde
Publisher:
ISBN: 9781645166498
Category : Farm life
Languages : en
Pages : 385

Book Description
George Terrill struggles with professional enmity while trying to come to terms with a family crisis. From being a young farm boy in Waldwick, Wisconsin, to a member of one of the state’s wealthiest families, George has come a long way. Life with Amelia and three adult children is going great. But as ‘Little Spirit,’ he knows he has yet a lot to give to humanity. As he shifts his focus from the field of commerce to health and begins working on the development of Mediglove, a life-altering technology that can bring revolution in the health industry, old friends-turned-enemies step in, posing immense hurdles in his path. Meanwhile, a family crisis makes George question the consequences of too much human intervention in God’s plans. The tough as nails but also achingly vulnerable George’s goodness and humanity make readers champion his cause throughout the story.

The Hayflick Limit

The Hayflick Limit PDF Author: Matthew Tierney
Publisher: Coach House Books
ISBN: 1552452174
Category : Poetry
Languages : en
Pages : 89

Book Description
Shifting focus from the limits of the telescope to the limits of the microscope, the poems in Matthew Tierneys second collection place a premium on inventiveness while embracing extremes of fear, pain, cognition and time. With demotic verve and a humming line, he gives voice to a range of characters who scrape out meaning in a carnivalesque universe that has birthed black holes and Warner Bros. cartoons, murky market economies, murkier quantum laws, Vincent Price, Molotov cocktails, seedless grapes, Area 51 and competing Theories of Everything.To be human is to cope with knowing. In the early 60s, Leonard Hayflick determined that healthy cells can divide only a finite number of times. Known as the Hayflick Limit, it sets an unsurpassable lifespan for our species at just over 120 years. The ultimate of limits, tackled by poetry of humour, intelligence and lucidity.The Hayflick Limit concerns itself with the boundaries of the cosmic and subatomic how the mind contains both and the sadsack creatures in the nexus, human beings. What does it mean to be an intelligent species? What does it mean to be an intelligent person?

Telomeres and Telomerase in Cancer

Telomeres and Telomerase in Cancer PDF Author: Keiko Hiyama
Publisher: Springer Science & Business Media
ISBN: 1603278796
Category : Medical
Languages : en
Pages : 375

Book Description
Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

The Evolution of Senescence in the Tree of Life

The Evolution of Senescence in the Tree of Life PDF Author: Richard P. Shefferson
Publisher: Cambridge University Press
ISBN: 1108138608
Category : Science
Languages : en
Pages : 445

Book Description
The existing theories on the evolution of senescence assume that senescence is inevitable in all organisms. However, recent studies have shown that this is not necessarily true. A better understanding of senescence and its underlying mechanisms could have far-reaching consequences for conservation and eco-evolutionary research. This book is the first to offer interdisciplinary perspectives on the evolution of senescence in many species, setting the stage for further developments. It brings together new insights from a wide range of scientific fields and cutting-edge research done on a multitude of different animals (including humans), plants and microbes, giving the reader a complete overview of recent developments and of the controversies currently surrounding the topic. Written by specialists from a variety of disciplines, this book is a valuable source of information for students and researchers interested in ageing and life history traits and populations.

Chance, Development, and Aging

Chance, Development, and Aging PDF Author: Caleb Ellicott Finch
Publisher: Oxford University Press, USA
ISBN: 9780195133615
Category : Aging
Languages : en
Pages : 298

Book Description
Chance, Development, and Aging analyzes a subject that has been largelyignored until now: the sources of individual variations in development and agingthat cannot be attributed to genes or the external environment. And by doing so,this book develops new insight on aging and the individual. Gathering andscrutinizing evidence from diverse sources, the authors examine thosedifferences in individuals that arise during development and those that mightinfluence outcomes of aging. Through their research, they pose a new set ofquestions about the contribution of chance events during development, andalthough chance variations during development are well known within thesub-fields of developmental biology, there has been little recognition of theiraffects on variations in adult form and function. Here, the authors confrontthis issue with a fascinating hypothesis: chance variations in form andfunction, arising through development, affect individual base-line functions andindividual responses to the external environment and so modify outcomes ofaging. This book will undoubtedly benefit gerontologists, geneticists,reproductive biologists, and physiologists, and it will fascinate all thoseinterested in the outcomes of aging.