Author: Kathryn Ellen DavisPublisher:
ISBN:
Category :
Languages : en
Pages : 374
Book Description
The Forkhead Transcription Factors, FoxC2 and FoxO1, Regulate Adipocyte Differentiation
Author: Kathryn Ellen DavisHeterozygous Deletion of the FoxO1 Forkhead Transcription Factor Confers Protection Against High Fat Diet-induced Insulin Resistance
Author: Hayley BainesPublisher:
ISBN:
Category :
Languages : en
Pages : 21
Book Description
Objective: Forkhead box O (FoxO) transcription factors represent evolutionarily conserved targets of insulin signaling, regulating metabolism and cellular differentiation in response to changes in nutrient availability. Although the FoxO1 isoform is known to play a key role in adipogenesis, its physiologic role in differentiated adipose tissue remains unclear. Research design and methods: In this study, we analyze the phenotype of FoxO1 haploinsufficient mice to investigate the role of FoxO1 in high fat-diet-induced obesity and adipose tissue metabolism. Specific assays include glucose and insulin tolerance tests, western blots, quantitative PCR, histologic analysis, and measurement of serum cytokines. Results: We show that reduced FoxO1 expression protects mice against obesity-related insulin resistance with increased PPAR[gamma] gene expression in adipose tissue and enhanced expression of known PPAR[gamma] target genes. Moreover, treatment of mice with the PPAR[gamma] agonist rosiglitazone improves in vivo insulin sensitivity in FoxO1 haploinsufficient animals, with reductions in circulating proinflammatory cytokines. Conclusions: These findings indicate that FoxO1 negatively regulates insulin action, and that this effect may be explained, at least in part, by inhibition of PPAR[gamma] activity.
New Transcription Factors and Their Role in Diabetes and Therapy
Author: Jacob E. FriedmanPublisher: Elsevier
ISBN: 008046355X
Category : Medical
Languages : en
Pages : 331
Book Description
This book contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this book provides a comprehensive look at how transcription factors may underline the pathogenetic mechanisms of diabetes and obesity. Volume 5 provides an overview of the status of the field, while also providing valuable information of practical utility to those who do not necessarily work in this field. The integration of basic biology with physiologically and clinically relevant proteins should provide the reader with a theoretical background to understanding the strategies for new potential therapeutic targets and their application to disease. *Applies molecular biology to transcriptional regulation of metabolism and obesity*Underscores the clinical relevance of transcription factors*Provides a valuable overview of the current status of the field
Gene Regulation During Adipocyte Differentiation
Author: Lena SamuelssonPublisher:
ISBN:
Category : Adipose tissues
Languages : en
Pages : 86
Book Description
Foxf2 and Foxc2, Two Transcription Factors that Regulate Adipocyte
Author: Rickard WestergrenPublisher:
ISBN: 9789162881191
Category :
Languages : en
Pages : 50
Book Description
Mouse Models of the Nuclear Envelopathies and Related Diseases
Author: Publisher: Elsevier
ISBN: 0123984645
Category : Science
Languages : en
Pages : 359
Book Description
Volume 109 of Current Topics in Developmental Biology covers mouse models of the nuclear envelopathies and related diseases, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson’s and dystonia, muscle ageing and sarcopenia, cardiac failure and repair, ageing and prospects lifespan extension, lipodystrophy and the significance in fat regulation, also identifying developmental mutations in mammals and nuclear envelope and LINC complex in disease. Covers the area of mouse models of developmental genetic disease International board of authors Provides a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson’s, muscle aging, lipodystrophy, and more
Metabolic Syndrome and Cardiovascular Disease
Author: T. Barry LevinePublisher: John Wiley & Sons
ISBN: 1118480074
Category : Medical
Languages : en
Pages : 967
Book Description
Trends indicate that the metabolic syndrome will become the leading risk factor for heart disease. Now more than ever you need an all-in-one reference that provides the tools and practical advice you need to: Identify at-risk patients Explain individual contributing factors Aid in patient education and motivation Direct comprehensive care and Choose the most appropriate interventions Comprehensively revised to reflect leading-edge research and now organized to facilitate easy access to essential information and clinically-relevant guidance, Metabolic Syndrome and Cardiovascular Disease, 2e offers this and more. Not only will you receive a solid understanding of the pathophysiology underlying the metabolic syndrome and cardiovascular disease but also the rationale for today’s most effective treatments. What’s new? Filled with timely new content, this updated edition covers: New discoveries that have changed our understanding of the pathogenesis and interrelationship of metabolic syndrome, cardiovascular disease (CHD), and type 2 diabetes mellitus (DM) The relevance of mitochondria and telomeres Sleep and its impact on cardiometabolic health The pivotal interplay between insulin and forkhead transcriptionfactors Calorie restriction research Bariatric surgery experiences and outcomes In addition, each chapter includes essential information on comorbidities, interventions, and pharmacotherapeutic options – an exclusive feature found only in the second edition!
Differentiation and Regulation of Bone Marrow Mesenchymal Stromal Cells
Author: Xiao ChenPublisher: Frontiers Media SA
ISBN: 2889767566
Category : Science
Languages : en
Pages : 206
Book Description
mTOR in Human Diseases
Author: Olivier DormondPublisher: MDPI
ISBN: 3039210602
Category : Medical
Languages : en
Pages : 480
Book Description
The mechanistic target of rapamycin (mTOR) is a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes, including protein, lipid, and nucleotide synthesis, as well as autophagy. Over the last two decades, major molecular advances have been made in mTOR signaling and have revealed the complexity of the events implicated in mTOR function and regulation. In parallel, the role of mTOR in diverse pathological conditions has also been identified, including in cancer, hamartoma, neurological, and metabolic diseases. Through a series of articles, this book focuses on the role played by mTOR in cellular processes, metabolism in particular, and highlights a panel of human diseases for which mTOR inhibition provides or might provide benefits. It also addresses future studies needed to further characterize the role of mTOR in selected disorders, which will help design novel therapeutic approaches. It is therefore intended for everyone who has an interest in mTOR biology and its application in human pathologies.
Author: