Author: New York University. Medical CenterPublisher:
ISBN:
Category : Cancer
Languages : en
Pages : 53
Book Description
The Fifth Conference on DNA Topoisomerases in Therapy
Author: New York University. Medical CenterPublisher:
ISBN:
Category : Cancer
Languages : en
Pages : 53
Book Description
First Conference on DNA Topoisomerases in Cancer Chemotherapy
Author: Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 162
Book Description
Journal of the National Cancer Institute
Author: Biomedical Index to PHS-supported Research: pt. A. Subject access A-H
Author: Biomedical Index to PHS-supported Research
Author: DNA Topoisomerases in Cancer Therapy
Author: Toshiwo AndohPublisher: Springer Science & Business Media
ISBN: 9780306477447
Category : Medical
Languages : en
Pages : 224
Book Description
This volume commemorates the 30th anniversary of the discovery in 1971 of the first DNA topoisomerases, i.e topoisomerase I in E. coli, then provisionally named `omega' protein, by the pioneering work of Jim Wang at Harvard University, who has contributed an article to this volume: `Reflections on an accidental discovery' of the enzyme. Many kinds of topoisomerase have since been found from type I through to type VI in a variety of organisms ranging from viruses to higher eukaryote mammals. The wide distribution of enzymes in various forms of life implies that the DNA topoisomerase is essential for life. In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.
Advances in DNA Sequence-specific Agents
Author: M. PalumboPublisher: Elsevier
ISBN: 008054455X
Category : Science
Languages : en
Pages : 297
Book Description
In this volume the entire focus is devoted to the macromolecule target specificity of DNA interactive developmental therapeutic agents of current interest. A brief introduction to DNA interactive anticancer agents is included for readers who may benefit from an overview surrounding the developments that have contributed to our general understanding of this field. The following nine chapters have been carefully chosen so that they describe topics which are at the forefront of development in DNA-targeted cancer chemotherapy. Issues that have been addressed include the mechanisms of selective DNA topoisomerase I and II poisoning by antitumor agents (Chapters 1 and 2), sequence-specific recognition of DNA by groove-binding drugs and drug-conjugates (Chapters 3 and 4), recent developments in nitrogen mustard alkylating agents and their potential use for antibody-directed enzyme-prodrug therapy (Chapter 5), nonclassical platinum anticancer complexes, including dinuclear and trans-platinum derivatives (Chapter 6), DNA cleaving antitumor chromoproteins containing reactive enediyne moieties, which exhibit interesting free-radical chemistry along with selective targeting (Chapter 7), the potential of new sequence-specific antisense and antigene therapy in oncology (Chapter 8), and finally the conceivable chemotherapeutic use of mimetics of the DNA structure, obtained by substitution of the sugar-phosphate natural chain with a peptide backbone, the so-called peptide nucleic acids (Chapter 9). Important approaches being currently investigated for selective cancer treatment, such as gene therapy and immunochemotherapy, are not discussed in this volume since they fall beyond its scope.
First Conference on DNA Topoisomerases in Cancer Chemotherapy
Author: National Library of Medicine Current Catalog
Author: National Library of Medicine (U.S.)Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1332
Book Description
Current Catalog
Author: National Library of Medicine (U.S.)Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1144
Book Description
First multi-year cumulation covers six years: 1965-70.