The Fibroblast Growth Factor Family in the Early Development of Xenopus Laevis PDF Download

Author: Harry Victor Isaacs
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: Michael V. Zuck
Publisher:
ISBN:
Category : Fibroblast growth factors
Languages : en
Pages : 244

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Author: Gordon W. Nash
Publisher:
ISBN:
Category : Fibroblast growth factors
Languages : en
Pages : 212

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Author: Wendy Winsor
Publisher:
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Category :
Languages : en
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In a search for fibroblast growth factor (FGF)-regulated early response genes, four cDNA fragments were isolated via a polymerase chain reaction-based differential display procedure. The cDNA fragments represent portions of genes that were either activated or repressed in Stage 8 Xenopus laevis explants after a 30 minute treatment with lOOng/ml XFGF-2. One 498bp cDNA fragment, named Band V, represents a gene that is downregulated by FGF treatment. This gene is expressed at Stages 8, 9 and 15 in the developing Xenopus embryo. A Genbank homology search program revealed similarity of Band V to distinct regions in an alternatively spliced myocyte enhancer factor, the v-j- c region of a T-cell receptor gamma chain, a Meprin A beta-subunit precursor and a myosin I heavy chain-like protein. The three other cDNA bands isolated from the differential display were chosen due to apparent upregulation by FGF. The 449bp Band VIA/B cDNA fragment possesses regions of similarity to the reactive centre of murine serine proteinase inhibitor 2.4 and a contrapsin-related MC-7 precursor. Upregulation of Band VIA/B was not confirmed because gene expression could not be detected via PCR in Xenopus explants or throughout development. The third Band 11/12, is a 636bp cDNA fragment whose gene is only expressed at Stage 8 of the developing embryo and was upregulated by FGF-2, in a PCR reaction. A database homology search showed that Band 11/12 was similar to a hypothetical protein. A second, 190bp DNA fragment isolated from Band 12 was a portion of the c-mos protooncogene. The fourth and final cDNA Band 22 is 517bp in size and represents a previously cloned Xenopus 146kDa nuclear splicing factor (Schmidt-Zachmann et aL, 1998). This factor is expressed throughout Xenopus development, and control of Band 22 gene expression by FGF-2 could not be confirmed.

Author: Jihwan Song
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Author: Robert C. Bast, Jr.
Publisher: John Wiley & Sons
ISBN: 111900084X
Category : Medical
Languages : en
Pages : 2004

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Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author: Malgorzata Kloc
Publisher: John Wiley & Sons
ISBN: 1118492811
Category : Science
Languages : en
Pages : 459

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Frogs from the genus Xenopus have long been used as model organisms in basic and biomedical research. These frogs have helped unlock key fundamental developmental and cellular processes that have led to important scientific breakthroughs and have had practical application in embryology, cancer research and regenerative medicine. Xenopus Development is a vital resource on the biology and development of these key model organisms, and will be a great tool to researchers using these frogs in various disciplines of biological science. Xenopus Development is divided into four sections, the first three highlight key processes in Xenopus development from embryo to metamophosis. These sections focus on the cellular processes, organogenesis and embryo development. The final section highlights novel techniques and approaches being used in Xenopus research. Providing thorough and detailed coverage, Xenopus Development, will be a timely and welcome volume for those working in cell and molecular biology, genetics, developmental biology and biomedical research. Provides broad overview of the developmental biology of both Xenopus laevis and Xenopus tropicalis Explores cellular to systems development in key biomedical model organisms Timely synthesis of the field of Xenopus biology Highlights key biomedical and basic biological findings unlocked by Xenopus

Author: Paul T. Sharpe
Publisher: Springer Science & Business Media
ISBN: 1592592708
Category : Science
Languages : en
Pages : 752

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Most people have some interest in embryos; this probably results, in part, from their interest in understanding the biological origins of themselves and their offspring and, increasingly, concerns about how environmental change such as pollution might affect human development. Obviously, et- cal considerations preclude experimental studies of human embryos and, c- sequently, the developmental biologist has turned to other species to examine this process. Fortunately, the most significant conclusion to be drawn from the experimental embryology of the last two decades is the manner in which orthologous or closely related molecules are deployed to mediate similar - velopmental processes in both vertebrates and invertebrates. The molecular mechanisms regulating processes fundamental to most animals, such as axial patterning or axon guidance, are frequently conserved during evolution. (It is now widely believed that the differences between phyla and classes are the result of new genes, arising mostly by duplication and divergence of extant sequences, regulating the appearance of derived characters. ) Other vertebrates are obviously most likely to use the same devel- mental mechanisms as humans and, within the vertebrate subphylum, the - parent degree of conservation of developmental mechanism is considerable. It has long been recognized that particular vertebrate species offer either d- tinct advantages in investigating particular stages of development or are - pecially amenable to particular manipulations. No single animal can provide all the answers because not all types of experiments can be carried out on a single species.

Author: Mary Elizabeth Pownall
Publisher: Morgan & Claypool Publishers
ISBN: 1615040633
Category : Science
Languages : en
Pages : 87

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This volume is a printed version of a work that appears in the Colloquium Digital Library of Life Sciences. Colloquium titles cover all of cell and molecular biology and biomedicine, including the neurosciences, from the advanced undergraduate and graduate level up to the post-graduate and practicing researcher level. They offer concise, original presentations of important research and development topics, published quickly, in digital and print formats. For more information, visit www.morganclaypool.com --Book Jacket.

Author: Sir John Kendrew
Publisher: John Wiley & Sons
ISBN: 1444313843
Category : Science
Languages : en
Pages : 1201

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The Encylopaedia of Molecular Biology is a truly unique work of reference. 6000 definitions cover the entire spectrum of molecular life science The complete one-volume guide to understanding the way molecular biology is transforming medicine and agriculture Long and short entries written by over 300 of the world's finest researchers For rapid research or detailed study ... this is the A to Z of the New Biology