The Fetal Origins of Metabolic Disorders PDF Download

Author: Takahiro Nemoto
Publisher: Frontiers Media SA
ISBN: 2889766640
Category : Medical
Languages : en
Pages : 150

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Author: Peter Gluckman
Publisher: Cambridge University Press
ISBN: 9780521847438
Category : Medical
Languages : en
Pages : 542

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Book Description
This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.

Author: He-Feng Huang
Publisher: Springer Science & Business Media
ISBN: 9400777728
Category : Health & Fitness
Languages : en
Pages : 229

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Book Description
The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal gametogenesis and embryo development, which manifests as growth retardation, birth defects, or increased susceptibility to chronic metabolic diseases such as diabetes, cardiovascular disease and cancer in childhood and adult life, even fertility disorders and the risk of transgenerational transmission. Six common kinds of these diseases are discussed in separate chapters. The authors explore the connections between these diseases and epigenetic reprogramming, rapid cell differentiation and organ formation and environmental influences, including assisted reproductive technology and adverse intrauterine environments. With a summary of findings on the causes and progression of adult diseases at the phase of gametogenesis and embryo development, this book provides insights into the pathogenesis of disease and aids in the treatment and prevention of disease, meeting the requirement for improving the quality of the newborn population, and effectively preventing and curing major diseases at an early stage. This book offers new perspectives and will be an enlightening resource for obstetricians, paediatricians, epidemiologists, endocrinologists and sanitarians. Editor He-Feng Huang, M.D., is Professor and President of Women’s Hospital, School of Medicine, Zhejiang University, China. Editor Jian-Zhong Sheng, Ph.D., is Professor at the Department of Pathology & Pathophysiology, School of Medicine, Zhejiang University, China.

Author: Dorairaj Prabhakaran
Publisher: World Bank Publications
ISBN: 1464805202
Category : Medical
Languages : en
Pages : 948

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Book Description
Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.

Author: Hui Wang
Publisher: Springer
ISBN: 9789819757299
Category : Science
Languages : en
Pages : 0

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Book Description
This book covers two decades of the author’s studies about fetal-originated diseases. It contains researches from the aspects of multiple inducing factors of fetal-originated diseases, including prenatal xenobiotic exposure, nutritional deficiency and other adverse environment during pregnancy. The authors introduce a series of animal models for studying the fetal origin of a variety of metabolic and neuropsychiatric diseases, and propose the mechanisms of developmental toxicity and susceptibility to multiple diseases, such as glucocorticoid programming. Moreover, the extended knowledge are also clearly addressed, like identification of biomarkers of developmental toxicity, and the strategies for early warning, prevention and treatment of fetal-originated diseases. Thus, the book is a systematic and complete reference for the researchers of related areas.

Author: Neal Halfon
Publisher: Springer
ISBN: 3319471430
Category : Medical
Languages : en
Pages : 667

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This book is open access under a CC BY 4.0 license. ​This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy. Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes. Pregnancy complications and their effect on women’s cardiovascular health. A multi-level approach for obesity prevention in children. Application of the LCHD framework to autism spectrum disorder. Socioeconomic disadvantage and its influence on health development across the lifespan. The importance of nutrition to optimal health development across the lifespan. The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health, mental health, education, social welfare, economics, sociology, and law.

Author: Vinood B. Patel
Publisher: Springer
ISBN: 9783319555294
Category : Medical
Languages : en
Pages : 0

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Book Description
This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.

Author: David J. Barker
Publisher: CRC Press
ISBN: 9780824703912
Category : Medical
Languages : en
Pages : 432

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Book Description
This watershed reference presents epidemiological, clinical, and experimental evidence that cardiovascular disease, Type 2 diabetes, and chronic lung disease originate through adaptations to the intrauterine environment. These new findings suggest that major chronic diseases in adult life may be prevented by improving the nutrition of girls and young women to promote healthy fetal development during pregnancy. Focusing on prenatal programming-the process whereby stimuli or insults at critical early periods of life have lasting effects-Fetal Origins of Cardiovascular and Lung Disease demonstrates the associations between low birthweight and cardiovascular disease and Type 2 diabetes in adults reveals the association between prenatal influences and hypertension and asthma in adult life describes pancreatic development in the fetus when the mother is malnourished or experiences metabolic disturbances during pregnancy examines the effects of undernutrition during gestation in experimental animal models discusses how the human fetus adapts to variations in maternoplacental nutrient supply details fetal influences on lipid metabolism, insulin sensitivity, the somatotrophic axis, andrenarche, and pubarche and more! Investigating when nurturing begins to influence and modulate gene expression, Fetal Origins of Cardiovascular and Lung Disease is critical for pulmonologists, cardiologists, pediatricians, neonatologists, obstetricians, internists, family practice physicians, and hospital interns and residents.

Author: Jonathan C. K. Wells
Publisher: Cambridge University Press
ISBN: 1107009472
Category : Business & Economics
Languages : en
Pages : 625

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Book Description
A multidisciplinary analysis of the role of nutrition in generating hierarchical societies and cultivating a global epidemic of chronic diseases.

Author: E. Gilbert-Barness
Publisher: IOS Press
ISBN: 1614997187
Category : Medical
Languages : en
Pages : 960

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Book Description
The 2nd Edition of Metabolic Diseases provides readers with a completely updated description of the Foundations of Clinical Management, Genetics, and Pathology. A distinguished group of 31 expert authors has contributed 25 chapters as a tribute to Enid Gilbert-Barness and the late Lewis Barness--- both pioneers in this topic. Enid’s unique perspectives on the pathology of genetic disorders and Lew’s unsurpassed knowledge of metabolism integrated with nutrition have inspired the contributors to write interdisciplinary descriptions of generally rare, and always challenging, hereditary metabolic disorders. Discussions of these interesting genetic disorders are organized in the perspective of molecular abnormalities leading to morphologic disturbances with distinct pathology and clinical manifestations. The book emphasizes recent advances such as development of improved diagnostic methods and discovery of new, more effective therapies for many of the diseases. It includes optimal strategies for diagnosis and information on access to specialized laboratories for specific testing. The target audience is a wide variety of clinicians, including pediatricians, neonatologists, obstetricians, maternal-fetal specialists, internists, pathologists, geneticists, and laboratorians engaged in prenatal and/or neonatal screening. In addition, all scientists and health science professionals interested in metabolic diseases will find the comprehensive, integrated chapters informative on the latest discoveries. It is our hope that the 2nd Edition will open new avenues and vistas for our readers and that they will share with us the interest, excitement and passion of the research into all these challenging disorders.