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Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide

Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide PDF Author: Agency for Health Care Research and Quality (U.S.)
Publisher: Government Printing Office
ISBN: 1587634236
Category : Medical
Languages : en
Pages : 236

Book Description
This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)

Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide

Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide PDF Author: Agency for Health Care Research and Quality (U.S.)
Publisher: Government Printing Office
ISBN: 1587634236
Category : Medical
Languages : en
Pages : 236

Book Description
This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)

Exposure

Exposure PDF Author: Robert Bilott
Publisher: Atria Books
ISBN: 1501172824
Category : Biography & Autobiography
Languages : en
Pages : 400

Book Description
“For Erin Brockovich fans, a David vs. Goliath tale with a twist” (The New York Times Book Review)—the incredible true story of the lawyer who spent two decades building a case against DuPont for its use of the hazardous chemical PFOA, uncovering the worst case of environmental contamination in history—affecting virtually every person on the planet—and the conspiracy that kept it a secret for sixty years. The story that inspired Dark Waters, the major motion picture from Focus Features starring Mark Ruffalo and Anne Hathaway, directed by Todd Haynes. 1998: Rob Bilott is a young lawyer specializing in helping big corporations stay on the right side of environmental laws and regulations. Then he gets a phone call from a West Virginia farmer named Earl Tennant, who is convinced the creek on his property is being poisoned by runoff from a neighboring DuPont landfill, causing his cattle and the surrounding wildlife to die in hideous ways. Earl hasn’t even been able to get a water sample tested by any state or federal regulatory agency or find a local lawyer willing to take the case. As soon as they hear the name DuPont—the area’s largest employer—they shut him down. Once Rob sees the thick, foamy water that bubbles into the creek, the gruesome effects it seems to have on livestock, and the disturbing frequency of cancer and other health problems in the area, he’s persuaded to fight against the type of corporation his firm routinely represents. After intense legal wrangling, Rob ultimately gains access to hundreds of thousands of pages of DuPont documents, some of them fifty years old, that reveal the company has been holding onto decades of studies proving the harmful effects of a chemical called PFOA, used in making Teflon. PFOA is often called a “forever chemical,” because once in the environment, it does not break down or degrade for millions of years, contaminating the planet forever. The case of one farmer soon spawns a class action suit on behalf of seventy thousand residents—and the shocking realization that virtually every person on the planet has been exposed to PFOA and carries the chemical in his or her blood. What emerges is a riveting legal drama “in the grand tradition of Jonathan Harr’s A Civil Action” (Booklist, starred review) about malice and manipulation, the failings of environmental regulation; and one lawyer’s twenty-year struggle to expose the truth about this previously unknown—and still unregulated—chemical that we all have inside us.

Understanding Exposure, Fourth Edition

Understanding Exposure, Fourth Edition PDF Author: Bryan Peterson
Publisher: Amphoto Books
ISBN: 1607748517
Category : Photography
Languages : en
Pages : 178

Book Description
This newly revised edition of Bryan Peterson's most popular book demystifies the complex concepts of exposure in photography, allowing readers to capture the images they want. Understanding Exposure has taught generations of photographers how to shoot the images they want by demystifying the complex concepts of exposure in photography. In this newly updated edition, veteran photographer Bryan Peterson explains the fundamentals of light, aperture, and shutter speed and how they interact with and influence one another. With an emphasis on finding the right exposure even in tricky situations, Understanding Exposure shows you how to get (or lose) sharpness and contrast in images, freeze action, and take the best meter readings, while also exploring filters, flash, and light. With all new images, as well as an expanded section on flash, tips for using colored gels, and advice on shooting star trails, this revised edition will clarify exposure for photographers of all levels.

Exposure Therapy for Anxiety

Exposure Therapy for Anxiety PDF Author: Jonathan S. Abramowitz
Publisher: Guilford Publications
ISBN: 146253970X
Category : Psychology
Languages : en
Pages : 478

Book Description
Now revised and expanded to include cutting-edge acceptance-based techniques and a new focus on inhibitory learning, this is the leading guide to therapeutic exposure, a crucial element of evidence-based psychological treatments for anxiety. The book helps the clinician gain skills and confidence for implementing exposure successfully and tailoring interventions to each client's needs, regardless of diagnosis. The theoretical and empirical bases of exposure are reviewed and specialized assessment and treatment planning techniques are described. User-friendly features include illustrative case examples, sample treatment plans, ideas for exercises targeting specific types of fears, and reproducible handouts and forms that can be downloaded and printed in a convenient 8½" x 11" size. New to This Edition *Chapter on acceptance and commitment therapy (ACT) techniques. *Reflects a shift in the field toward inhibitory learning--helping clients learn to tolerate anxiety and uncertainty to maximize long-term outcomes. *Chapter on uses of technology, such as computer-based therapy and virtual reality tools. *Conceptual, empirical, and clinical advances woven throughout. See also the related client recommendation, The Anxiety and Worry Workbook, Second Edition, by David A. Clark and Aaron T. Beck.

Mastering Long Exposure

Mastering Long Exposure PDF Author: A. Zacharias
Publisher: Ammonite Press
ISBN: 9781781453216
Category : Photography
Languages : en
Pages : 0

Book Description
Whether you're taking photographs in the dead of night or looking to create an ethereal effect with water or clouds during the day, long exposures are among the most challenging areas of photography. Very often there are physical obstacles to overcome, whether it's being unable to see to frame your shot or focus, an inability to predict movement during the exposure, or simply the need to hold your camera steady while the shutter is open. There are also numerous technical issues to resolve, such as striking a balance between ISO and noise, dealing with high dynamic range, and maintaining the best possible image quality when the laws of physics are working against you. Yet, just as the demands placed upon the photographer are exceptional, so too are the images that can be created when you push your camera to its limits. Packed with stunning photography throughout, the author's expert advice, tips, and tricks are augmented by Masterclasses from some of the world's leading long exposure champions, each sharing the secrets of their success. So whether you want to master star trail photography, shoot cityscapes at dusk, paint with light, or use blur creatively, this is the only book you'll need.

Bryan Peterson's Exposure Solutions

Bryan Peterson's Exposure Solutions PDF Author: Bryan Peterson
Publisher: Amphoto Books
ISBN: 0770433057
Category : Photography
Languages : en
Pages : 146

Book Description
Easy answers for your most common exposure questions Bryan Peterson’s Understanding Exposure has demystified the elements of exposure for nearly half a million readers, making it one of the most popular photography books in the world. Now, Bryan returns with his first-ever follow-up, Bryan Peterson’s Exposure Solutions, this time tackling 28 of the most common exposure stumbling blocks for amateur shooters. These are the exposure situations that prove frustrating time and time again, from exposing high-contrast scenes to freezing action in low light, photographing a full moon, exposing subjects against a sunset sky, balancing subjects in shade with brightly lit backgrounds, and so on. For each, Bryan points out common pitfalls and then offers a simple solution, showing you how to approach the exposure differently and transform your shot. A complement to Understanding Exposure, Bryan Peterson’s Exposure Solutions digs deeper to help you break bad habits, take control of your exposure, and approach even tricky situations with confidence.

Exposure

Exposure PDF Author: Louis Greenberg
Publisher: Titan Books (US, CA)
ISBN: 178909030X
Category : Fiction
Languages : en
Pages : 237

Book Description
In an alternate Britain, an immersive theatre like no other unravels a mystery from beyond the grave. Perfect for fans of Black Mirror. In a Britain akin to this one, Vincent Rice falls off a ladder, literally at Petra Orff’s feet. They introduce themselves, and immigrant Petra senses a kindred spirit in Vincent’s complex sense of home. He offers to take her to Metamuse, an alternative theatre experience like no other that he won tickets to in a competition he doesn’t remember entering. The first show leaves them besotted with each other; the second is far more disturbing. Inexplicable occurrences pile on top of one another, all connected to the mysterious Metamuse. Only Petra can see the web of sinister coincidences surrounding them both and, with injustices both past and present weighing on her mind, she begins to wonder if Metamuse is more than just a show…

Exposure

Exposure PDF Author: Mal Peet
Publisher: Candlewick Press
ISBN: 0763652458
Category : Young Adult Fiction
Languages : en
Pages : 431

Book Description
Carnegie Medalist Mal Peet takes a searing look at the world of soccer and pop-celebrity culture -- and the lives of three street kids caught in its glare. (Age 14 and up) When a black South American soccer star signs on to a team in the country’s racist south, headlines blare. And when he falls for the sensual Desmerelda, a stunning white pop singer and daughter of a wealthy politician, their sudden and controversial marriage propels the pair to center stage, where they burn in the media spotlight. But celebrity attracts enemies; some very close to home. And its dazzle reaches into the city’s hidden corners, exposing a life of grit and desperation the glitterati could never imagine. When a girl is found murdered, reporter Paul Faustino is caught between worlds as he witnesses the power of the media in making -- and breaking -- lives. Inspired by Shakespeare’s OTHELLO, this modern tragedy of desire and betrayal, incisively and compassionately told, is a truly enthralling work of crossover fiction.

The Northern Exposure Book

The Northern Exposure Book PDF Author: Louis Chunovic
Publisher: Carol Publishing Corporation
ISBN:
Category : Performing Arts
Languages : en
Pages : 236

Book Description


Exposure

Exposure PDF Author: Helen Dunmore
Publisher: Open Road + Grove/Atlantic
ISBN: 0802190413
Category : Fiction
Languages : en
Pages : 302

Book Description
“An unconventional thriller [and] a page turner . . . As much a surprising love story as it is a tale of spies” (The New York Times Book Review). In 1960 London, the Cold War is at its height, and a spy may be a friend or neighbor, colleague or lover. Two colleagues, Giles Holloway and Simon Callington, face a terrible dilemma over a missing top-secret file. At the end of a suburban garden, in the pouring rain, Simon’s wife, Lily, buries a briefcase containing the file deep in the earth. She believes that in doing so she is protecting her family. What she will learn is that no one is immune from betrayal or the devastating consequences of exposure. “Dunmore’s strategy, placing a triangle of past and present loves within a spy novel, yields an unexpected dividend. Even the most ordinary elements of life—the lengths to which a mother will go to protect her children, meeting someone special, what remains unsaid within a marriage—become viscerally exciting.” —The New Yorker “Exposure is many things at once—an espionage thriller, a forbidden-love story, an immigrant’s tale . . . A novel you won’t be able to shake.” —Entertainment Weekly “One of those books that you read with your heart in your mouth, your mind fully engaged, and with a sense of desolation as you note the dwindling number of pages left before it comes to an end.” —Chicago Tribune