Author: Y. RustumPublisher: Springer Science & Business Media
ISBN: 1468456075
Category : Medical
Languages : en
Pages : 328
Book Description
The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy
Author: Y. RustumPublisher: Springer Science & Business Media
ISBN: 1468456075
Category : Medical
Languages : en
Pages : 328
Book Description
The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy
Author: Y RustumPublisher:
ISBN: 9781468456080
Category :
Languages : en
Pages : 352
Book Description
National Library of Medicine Current Catalog
Author: National Library of Medicine (U.S.)Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1178
Book Description
Current Catalog
Author: National Library of Medicine (U.S.)Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1144
Book Description
First multi-year cumulation covers six years: 1965-70.
Concepts, Mechanisms, and New Targets for Chemotherapy
Author: Franco M. MuggiaPublisher: Springer Science & Business Media
ISBN: 146152007X
Category : Medical
Languages : en
Pages : 339
Book Description
Concepts, Mechanisms, and New Targets for Chemotherapy describes new interconnections between rationally designed and empirically discovered compounds. One route that has not been travelled previously is that of protein kinase C inhibition. This pathway may be exploited to give potent inhibitors, such as the bryostatins, now in clinical trial. A summary is given of the current status of topoisomerase, focusing on recent clinical advances with camptothecin analogs based on connecting empiricism with concepts of drug selectivity. Modification of existing therapies based on the pursuit of leads arising from mechanistic studies is also being applied clinically on a wide scale. Greater understanding should follow from the studies of reversal of the multidrug resistant phenotype, on the use of hydroxyurea to reverse resistance mediated by extrachromosomal DNA, and on various aspects of the fluoropyrimidine pathways. Successful applications of chemotherapy to the treatment of specific diseases include the growing applications of systemic therapy using various skin malignancies. In prostate cancer, estramustine phosphate will likely play an expanding role. Taxanes are restructuring treatment regimens in breast cancer, and high-dose strategies are described with peripheral blood progenitor autografting in the treatment of ovarian and breast cancers.
Journal of the National Cancer Institute
Author: New Drugs, Concepts and Results in Cancer Chemotherapy
Author: Franco M. MuggiaPublisher: Springer Science & Business Media
ISBN: 1461538769
Category : Medical
Languages : en
Pages : 173
Book Description
Current Catalog
Author: Publisher:
ISBN:
Category : Medicine
Languages : en
Pages :
Book Description
First multi-year cumulation covers six years: 1965-70.
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
Author: Stephen B. HowellPublisher: Springer Science & Business Media
ISBN: 030644027X
Category : Medical
Languages : en
Pages : 563
Book Description
Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations.
Novel Approaches to Selective Treatments of Human Solid Tumors
Author: Youcef M. RustumPublisher: Springer Science & Business Media
ISBN: 1461524881
Category : Medical
Languages : en
Pages : 306
Book Description