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Author: United States. Public Health Service. Office of the Surgeon General Publisher: ISBN: Category : Government publications Languages : en Pages : 728
Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: United States. Public Health Service. Office of the Surgeon General Publisher: ISBN: Category : Government publications Languages : en Pages : 728
Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: Leslie J. Fairbairn Publisher: Springer Science & Business Media ISBN: 1461548896 Category : Medical Languages : en Pages : 402
Book Description
Since the first concepts of gene therapy were formulated, the hemopoietic system has been considered the most natural first target tissue for genetic manipulation. The reasons for this include the fact that a very large number of inherited disorders (including some of the most common disorders, such as the hemoglobinopathies) are disorders of the hemopoietic system, and the large amount of experience in hematopoietic transplantation biology. The consequence of this resulted in the first clinical trial of gene therapy in 1989, where two children suffering from severe combined immune deficiency (ADA-SCID) were transplanted with T-cells express ing adenosine deaminase (the defective enzyme in patients with this disorder). The partial success of this treatment was perhaps responsible for undue optimism among those proposing other gene therapy treatments within the hematopoietic system, and it has since become clear that there are a number of technical and biological difficulties to overcome before hematopoietic gene therapy becomes a mainstream therapeutic strategy. The chapters in this book evaluate the need for gene therapy in the hematopoietic system, discuss how efficient gene transfer and expression can be achieved in the target cells, highlight areas of difficulty to be addressed, and examine a number of potential applications of the gene therapy approach. The book begins with a chapter by Testa and colleagues, discussing the various sources of hematopoietic cells for both transplantation and gene therapy.
Author: Mark D. Kilby Publisher: Cambridge University Press ISBN: 1107012139 Category : Medical Languages : en Pages : 471
Book Description
Covers the latest insights any fetal specialist needs and provides essential knowledge for professionals caring for women with high-risk pregnancies.
Author: Stephen Clift Publisher: Cambridge Scholars Publishing ISBN: 1443896055 Category : Medical Languages : en Pages : 245
Book Description
This book brings together leading UK researchers in the field of arts and health, including creative arts therapies. The chapters are based on presentations originally given at a UK seminar series on scholarship and research on connections between the creative arts, health and wellbeing, funded by the Economic and Social Research Council. It will be of interest to anyone practising or researching arts and health, in both hospitals and community settings. Because of the nature of the work, the volume is cross-disciplinary in theory and multi-disciplinary in practice. As such, it will appeal to a cross-section of practitioners and thinkers. Research in the field of arts, health and wellbeing has developed considerably in recent years, and in the dialogue of this book some of the big questions for the agenda are addressed.
Author: Marc E. de Broe Publisher: Springer Science & Business Media ISBN: 1402025866 Category : Medical Languages : en Pages : 719
Book Description
To you the reader, the joy of discovery begins, for We continue in our goal of providing a text which us the job is done. In this edition, we have corrected is useful, not only to the clinician, but of equal interest past deficiencies, added new topics, expanded infor- to the investigator. The selection of content has been mation regarding the pediatric age group, provided directed at topics of current interest rather than those up to date (March 2003) references, while remaining of historic contribution. We have stressed the cont- true to our concept of a multi-national author book. bution of cell biology and pathophysiology, were it We continue to believe that scientific information is an exists, believing it provides both a better understa- international commodity whose interpretation and ap- ing of toxic injury when known, and a rational dir- plication are strongly influenced by both the cultural tion for therapy and prevention. and ethnic background of the observer. The oppor- nity to share in the rich diversity of the international We are encouraged by the accumulation of rec- scientific community remains a fundamental goal of nized risk factors, which allow pre-treatment strati- this endeavor. To participate as equals leads to mu- cation of our patients’ relative risk and allow us to - tual respect and peer appreciation. The sharing of in- cus our preventative techniques on the individuals tellectual resources fostered by this effort should and most likely to gain the greatest benefit.
Author: Samuel M. Turner Publisher: Springer Science & Business Media ISBN: 1468446940 Category : Psychology Languages : en Pages : 445
Book Description
When behavior therapy was first applied to what would now be labeled an anxiety disorder, a simplistic theoretical model guided the treatment of a sim ple phobia. Time and research have shown that the techniques of behavior ther apy have been more successful than its models have been explanatory. Yet progress has been substantial in both realms, as the following volume makes patently clear. In 1980 an inventory of this progress was catalogued at an NIMH-sponsored workshop. What both that workshop and this volume clearly show is that the behav ior therapy researcher need no longer suffer the epithet "overly simplistic." One of the major strengths of this volume is its elucidation of the complexities that now attend the study of the anxiety disorders, particularly from a behav ioral point of view. The researcher at times appears almost to be buried in a landslide of complexities regarding this topic. The concept of anxiety itself has undergone a differentiation to a level of complexity that poses problems for both the conceptualization and the treat ment of anxiety disorders. In virtually one voice, the several authors of this volume argue the multidimensional nature of anxiety. The "lump" view of anx iety has given way to the three-channel view of anxiety. An investigator's future research career could well be secured just by spending time puzzling out the significance of the low intercorrelations among the channels.
Author: United States. Public Health Service. Office of the Surgeon General
Author: United States. Public Health Service. Office of the Surgeon General
Author: R. Murray Schafer
Author: 
Author: Leslie J. Fairbairn
Author: Mark D. Kilby
Author: Stephen Clift
Author: Arthur L. Frank
Author: David Jonassen
Author: Marc E. de Broe
Author: Samuel M. Turner