The Effective Temperatures of Gas-phase Biological Molecules Stored in a Quadrupole Ion Trap PDF Download
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Author: Geng Li Publisher: ISBN: 9780494388693 Category : Languages : en Pages : 164
Book Description
The internal energy distribution undergoing collision-induced dissociation (CID) in the cell of a quadrupole ion trap (QIT) mass spectrometer can be characterized by the effective temperature, which would help determine the activation energy and entropy. Here, the relationship in a Bruker QIT has been reexamined based on kinetic measurements at two qz values. An observed linear relationship between ion effective temperatures and resonant activation amplitudes appears qualitatively different from simplified theoretical simulation, which is in agreement with previous results on Finnigan ion trap. However, the normalization process aiming to compensate for the m/z dependency of the required fragmentation energy that is used successfully in Finnigan-geometry traps is not entirely successful for use in Bruker-geometry trans. The calibration determined here roughly indicates the relationship between ion effective temperature, resonant excitation amplitude and ion m/z. However, Successful extraction of the dissociation energetics still requires a better accuracy of the calibration.
Author: Geng Li Publisher: ISBN: 9780494388693 Category : Languages : en Pages : 164
Book Description
The internal energy distribution undergoing collision-induced dissociation (CID) in the cell of a quadrupole ion trap (QIT) mass spectrometer can be characterized by the effective temperature, which would help determine the activation energy and entropy. Here, the relationship in a Bruker QIT has been reexamined based on kinetic measurements at two qz values. An observed linear relationship between ion effective temperatures and resonant activation amplitudes appears qualitatively different from simplified theoretical simulation, which is in agreement with previous results on Finnigan ion trap. However, the normalization process aiming to compensate for the m/z dependency of the required fragmentation energy that is used successfully in Finnigan-geometry traps is not entirely successful for use in Bruker-geometry trans. The calibration determined here roughly indicates the relationship between ion effective temperature, resonant excitation amplitude and ion m/z. However, Successful extraction of the dissociation energetics still requires a better accuracy of the calibration.
Author: Anouk M. Rijs Publisher: Springer ISBN: 3319192043 Category : Science Languages : en Pages : 409
Book Description
The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students.
Author: Raymond E. March Publisher: CRC Press ISBN: 1420083724 Category : Science Languages : en Pages : 952
Book Description
Reflecting the substantial increase in popularity of quadrupole ion traps and Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers, Practical Aspects of Trapped Ion Mass Spectrometry, Volume IV: Theory and Instrumentation explores the historical origins of the latest advances in this expanding field. It covers new methods for trapp
Author: Peter H. Dawson Publisher: Elsevier ISBN: 1483165043 Category : Science Languages : en Pages : 372
Book Description
Quadrupole Mass Spectrometry and Its Applications provides a comprehensive discussion of quadrupoles and their applications. It proceeds from a general explanation of the action of radiofrequency quadrupole fields to the description of their utilization in mass analyzers—such as the quadrupole mass filter, the monopole, the three-dimensional quadrupole ion trap, and various time-of-flight spectrometers—and finally to the characteristic applications of quadrupoles. A multi-author format has been adopted to provide broader-than-usual viewpoint in the book. The book begins by explaining the principles of operation of quadrupole devices. These include ion trajectories and computer simulations of performance; analytical theory; numerical methods of calculation of performance, including the recently developed application of phase-space dynamics; and fringing fields and other field imperfections. Subsequent chapters provide design and performance evaluations of the mass filter, the monopole, ion traps, and time-of-flight instruments; and describe areas of application where quadrupole devices have made the greatest impact because of their particular advantages and disadvantages.
Author: Harald Seitz Publisher: John Wiley & Sons ISBN: 3527680675 Category : Science Languages : en Pages : 266
Book Description
Built on a decade of experience with novel molecular diagnostics, this practice-oriented guide shows how to cope with validation issues during all stages of biomarker development, from the first clinical studies to the eventual commercialization of a new diagnostic test.
Author: Geng Li
Author: Geng Li
Author: Anouk M. Rijs
Author: Natalia Nagornova
Author: Raymond E. March
Author: Peter H. Dawson
Author: Stefano Falcinelli
Author: Barry Levine
Author: Harald Seitz
Author: 
Author: John Michels (Journalist)