The Effect of Uncoupling Protein 2 on Proinsulin Processing PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download The Effect of Uncoupling Protein 2 on Proinsulin Processing PDF full book. Access full book title The Effect of Uncoupling Protein 2 on Proinsulin Processing by Narudee Kashemsant. Download full books in PDF and EPUB format.
Author: Narudee Kashemsant Publisher: ISBN: Category : Languages : en Pages :
Book Description
The present study showed that UCP2 reduced ATP content without altering ATP synthase, thereby impairing GSIS. UCP2 increased insulin gene transcription but reduced proinsulin processing in the UCP2 overexpression model. Free fatty acid exposure of beta cells also caused impaired insulin processing, but this could not be directly attributed to UCP2 gene expression or correlated with reductions in ATP production. Lastly, high fat diet in wildtype mice was sufficient to impair GSIS and proinsulin processing but did not significantly increase UCP2 expression, or reduce intracellular ATP. From the UCP2 overexpression studies we conclude that induction of UCP2 can influence proinsulin processing, presumably by reducing intracellular ATP concentrations. Whether fatty acids influence proinsulin processing via their effects on UCP2 expression or activity was inconclusive. The five week dietary regime was sufficient to induce changes in glucose-stimulated insulin secretion and proinsulin processing but was insufficient to affect UCP2. This suggests that early changes in insulin secretion are not attributable to UCP2 expression, although effects on activity cannot be ruled out.
Author: Narudee Kashemsant Publisher: ISBN: Category : Languages : en Pages :
Book Description
The present study showed that UCP2 reduced ATP content without altering ATP synthase, thereby impairing GSIS. UCP2 increased insulin gene transcription but reduced proinsulin processing in the UCP2 overexpression model. Free fatty acid exposure of beta cells also caused impaired insulin processing, but this could not be directly attributed to UCP2 gene expression or correlated with reductions in ATP production. Lastly, high fat diet in wildtype mice was sufficient to impair GSIS and proinsulin processing but did not significantly increase UCP2 expression, or reduce intracellular ATP. From the UCP2 overexpression studies we conclude that induction of UCP2 can influence proinsulin processing, presumably by reducing intracellular ATP concentrations. Whether fatty acids influence proinsulin processing via their effects on UCP2 expression or activity was inconclusive. The five week dietary regime was sufficient to induce changes in glucose-stimulated insulin secretion and proinsulin processing but was insufficient to affect UCP2. This suggests that early changes in insulin secretion are not attributable to UCP2 expression, although effects on activity cannot be ruled out.
Author: R. A. DeFronzo Publisher: John Wiley & Sons ISBN: 0470658614 Category : Medical Languages : en Pages : 1200
Book Description
The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.
Author: Roy E. Weiss Publisher: Academic Press ISBN: 0128011343 Category : Science Languages : en Pages : 462
Book Description
Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias. - Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases - Teaches the essentials of the genetic basis of disease in each major endocrine organ system - Offers expert advice from genetic counselors on how to use genetic information in counseling patients - Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing
Author: Robert C. Bast, Jr. Publisher: John Wiley & Sons ISBN: 111900084X Category : Medical Languages : en Pages : 2004
Book Description
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author: Alan R. Saltiel Publisher: Springer Science & Business Media ISBN: 0387722041 Category : Medical Languages : en Pages : 223
Book Description
More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
Author: Gordon C Weir Publisher: Elsevier Health Sciences ISBN: 0323221548 Category : Medical Languages : en Pages : 542
Book Description
Meet the growing challenges of diabetes and obesity management with Endocrinology: Adult and Pediatric: Diabetes Mellitus and Obesity - a new diabetes and obesity eBook from the same expert endocrinologists responsible for the highly acclaimed two-volume Endocrinology clinical reference. With all of the latest advances loaded on your favorite eReader, you’ll be able to put today’s best practices to work for your patients. Stay abreast of the newest knowledge and advances in diabetes mellitus and obesity, including today’s increased focus on controlling autoimmunity and preserving or replenishing beta-cell mass in the management of type 1 diabetes; complications of diabetes and their pathogenesis, morbidity, and treatment; new findings and treatments for obesity; and much more. Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and DeGroot, the go-to clinical reference for endocrinologists worldwide. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.
Author: J. Larry Jameson Publisher: Elsevier Health Sciences ISBN: 1455711268 Category : Medical Languages : en Pages : 3076
Book Description
ENDOCRINOLOGY, edited by J. Larry Jameson, MD, PhD and Leslie J. De Groot, MD, has been considered the definitive source in its field for decades. Now this landmark reference has been exhaustively updated to bring you the latest clinical guidance on all aspects of diagnosis and treatment for the full range of endocrine and metabolism disorders, including new information on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors. Entirely new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis keep you well informed on today’s hot topics. You’ll benefit from unique, global perspectives on adult and pediatric endocrinology prepared by an international team of renowned authorities. This reference is optimally designed to help you succeed in your demanding practice and ensure the best possible outcomes for every patient. Overcome virtually any clinical challenge with detailed, expert coverage of every area of endocrinology, authored by hundreds of leading luminaries in the field. Provide state-of-the-art care with comprehensive updates on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors ... brand-new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis ... expanded coverage of sports performance, including testosterone, androgen research, and bone growth and deterioration ... and the newest discoveries in genetics and how they affect patient care. Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. Rapidly consult with trusted authorities thanks to new expert-opinion treatment strategies and recommendations. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information more quickly, while still getting the complete coverage you expect.
Author: Narudee Kashemsant
Author: Narudee Kashemsant
Author: 
Author: Mark A. Sperling
Author: R. A. DeFronzo
Author: Roy E. Weiss
Author: Richard I. G. Holt
Author: Robert C. Bast, Jr.
Author: Alan R. Saltiel
Author: Gordon C Weir
Author: J. Larry Jameson